[Detection of genetic determinants that define the difference of near-isogenic Triticum aestivum L. Lines in photoperiodic sensitivity].

Identification of genetic determinants that define different degrees of line sensitivity to the photoperiod was conducted on material of near-isogenic lines of the soft hexaploid wheat Triticum aestivum L. using SSR markers and markers specific to the Vrn and Ppd genes. It was established that the Ppd-s line contains a dominant Ppd-Dla allele located on chromosome 2D. This allele is characterized by a vast deletion in the gene promoter region. For two other lines (Ppd-m and Ppd-w), introgression of the Ppd-B1 gene on chromosome 2B was shown from the parental Sonora variety, which is slightly sensitive to the length of the day; however, the previously described Ppd-Bla. 1 allele was not found. Another polymorphism that can cause weak photoperiodic sensitivity, an increased amount of the Ppd-B1 gene copies, was detected for these lines.

[Experimental evaluation of carcinogenic activity of nickel-containing dust]. / Eksperimentalnaia otsenka kantserogennoi aktivnosti nikelsoderzhashchikh pylei.

Chronic experiment confirmed blastomogenic effect of nickel-containing dust. Hemoblastoses were most frequent of the blastomas. There were also adenocarcinomas, pulmonary adenomas and carcinomas, renal adenocarcinoma, cortical adenoma. The dust with nickel and resinous fraction had most activity.

[Industrial aerosols and the prevention of oncologic diseases in the foundries of nickel-processing plants]. / Promyshlennye aérozoli i profilaktika onkologicheskoi zabolevaemosti v plavil'nykh tsekhakh nikelevykh zavodov.

On the basis of hygienic studies in foundries of nickel plants conditions for and character of the formation of industrial aerosols, their physico-chemical properties are studied. The data obtained indicate significant pollution in the occupational areas with ++nickel-containing aerosols. High carcinogenic risk has been shown to characterize the foundries. A dependence of workers' mortality due to malignant tumours on nickel and its compounds content in the air of occupational area has been shown. A complex of health-improving measures aimed at reducing oncological morbidity of workers in foundries of nickel plants is presented. A priority significance is attributed to application of new technological processes in production.

[Determination of potential carcinogenicity of nickel-containing dust using a micronuclear test]. / Opredelenie potentsial'noi kantserogennosti nikel'soderzhashchikh pylei s pomoshch'iu mikroiadernogo testa.

Mutagenic activity of 3 samples of nickel-containing dusts was experimentally studied in white random-bred rats. Quantity of micronuclei in polychromatophilic erythrocytes of bone marrow smear depended on nickel dust content. Micronuclear test could be used as a rapid method for the determination of potential carcinogenic activity of polymetallic nickel-containing dusts and also as a factor confirming oncologic hazard of chemical substances combined with epidemiologic studies and chronic experiment on animals.