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Effects of succinic and glutamic acid combination on energy metabolism in the liver of mice under conditions of hypoxia.
Vasilyev, K Yu; Kiselyova, A A; Khazanov, V A.
Bull Exp Biol Med ; 147(3): 335-8, 2009 Mar.
Article in English | MEDLINE | ID: mdl-19529856

ABSTRACT

Treatment of mice by a combination of succinic and glutamic acids prevented the metabolic disorders in the liver under conditions of normobaric hypoxia. In addition, the activity of the mitochondrial fast metabolic cluster remained intact and lipid peroxidation was limited.


Subject(s)
Energy Metabolism/drug effects , Glutamic Acid/pharmacology , Hypoxia/physiopathology , Liver/drug effects , Liver/metabolism , Succinic Acid/pharmacology , Animals , Drug Combinations , Lipid Peroxidation/drug effects , Male , Mice , Mitochondria, Liver/drug effects , Mitochondria, Liver/metabolism
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