Subject(s)
Acyclovir/analogs & derivatives , Antiviral Agents/administration & dosage , Cytomegalovirus Infections/drug therapy , Retinitis/drug therapy , Thymidine/analogs & derivatives , Acyclovir/administration & dosage , Adult , Ganciclovir , Humans , Injections , Male , Thymidine/administration & dosage , Vitreous Body , ZidovudineABSTRACT
The clinical and microbiologic features of group A streptococcal bacteremia are described in 40 patients, all of whom were seen between January 1982 and June 1983 and all of whom were intravenous drug abusers. Eleven patients had endocarditis (two with left-sided and nine with right-sided), and 29 patients had bacteremia without endocardial involvement. Twenty-seven of the 29 patients without endocarditis had soft tissue infections, primarily groin abscesses. Constitutional symptoms were more severe in patients with endocarditis. The two patients with left-sided endocarditis died despite antimicrobial therapy; all nine patients with right-sided endocarditis and all 29 patients without endocarditis were cured of their infection. A predominant strain of group A streptococcus was identified by serologic typing, suggesting a common source for these cases.
Subject(s)
Sepsis/etiology , Streptococcal Infections/etiology , Substance-Related Disorders/complications , Adult , Anti-Bacterial Agents/therapeutic use , Endocarditis, Bacterial/drug therapy , Endocarditis, Bacterial/etiology , Endocarditis, Bacterial/pathology , Female , Fever/etiology , Heart Murmurs , Humans , Injections, Intravenous/adverse effects , Male , Microbial Sensitivity Tests , Middle Aged , Sepsis/microbiology , Sepsis/pathology , Streptococcal Infections/microbiology , Streptococcal Infections/pathology , Streptococcus pyogenes/drug effects , Streptococcus pyogenes/isolation & purificationABSTRACT
A case of bacteremia caused by Achromobacter species in an immunocompromised patient is described. The patient responded to antibiotic therapy. Detailed antibiotic susceptibility data are presented.
Subject(s)
Alcaligenes/isolation & purification , Sepsis/microbiology , Adult , Alcaligenes/drug effects , Anti-Bacterial Agents/pharmacology , Drug Combinations/therapeutic use , Female , Gentamicins/therapeutic use , Humans , Immune Tolerance , Sepsis/drug therapy , Sulfamethoxazole/therapeutic use , Trimethoprim/therapeutic use , Trimethoprim, Sulfamethoxazole Drug CombinationABSTRACT
Acute renal failure occurred during indomethacin therapy in a patient with chronic pyelonephritis. Urinary prostaglandin E2 levels were diminished but returned to normal after discontinuation of drug therapy and recovery of renal function. Prostaglandins may be critical for the integrity of renal function, and the use of prostaglandin inhibitors such as indomethacin and other nonsteroidal anti-inflammatory drugs may be deleterious in patients with underlying renal disease.