1.
J Antibiot (Tokyo)
; 45(6): 892-8, 1992 Jun.
Article
in English
| MEDLINE
| ID: mdl-1500356
ABSTRACT
Two new platelet aggregation inhibitors, PI-200 and PI-201 were isolated from the fermentation broth of Streptomyces sp. A7498. PI-200 and PI-201 inhibited ADP-induced aggregation of rabbit platelets with an IC50 of 3.8 x 10(-4) M and 7.1 x 10(-4) M, respectively.
Subject(s)
Naphthalenes/isolation & purification , Phenanthrenes/isolation & purification , Platelet Aggregation Inhibitors/isolation & purification , Animals , Fermentation , Naphthalenes/chemistry , Naphthalenes/pharmacology , Phenanthrenes/pharmacology , Platelet Aggregation/drug effects , Platelet Aggregation Inhibitors/chemistry , Platelet Aggregation Inhibitors/pharmacology , Rabbits , Streptomyces/classification , Streptomyces/metabolism
2.
Chem Pharm Bull (Tokyo)
; 37(12): 3429-31, 1989 Dec.
Article
in English
| MEDLINE
| ID: mdl-2632093
ABSTRACT
From a cultured broth of Streptomyces matensis A-6621, we isolated three new platelet aggregation inhibitors designated as PI-080, PI-085 and PI-087. The structures of these compounds were established by spectral and chemical methods.
