ABSTRACT
OBJECTIVE: To establish a predictive role of blood serum cytokines and their effect on a clinical picture of patients with supratentorial meningiomas. MATERIAL AND METHODS: Levels of interleukin-4, interleukin-6 and γ-interferon were measured in 26 patients using immunoenzymatic method. Assessment of a predictive role of cytokine levels was carried out by a method of the analysis of multidimensional data and cluster analysis on the basis of Kokhonen's neural network. Correlation between cytokine level and scores on the Karnovsky scale at discharge from hospital was used as an indicator of treatment efficacy. RESULTS: The changes in interleukin-4 level had no impact on a clinical condition of patients while the fluctuations of blood serum played a significant role. CONCLUSION: To predict clinical condition and timely treatment correction in patients with supratentorial meningiomas, monitoring of interleukin-6 and γ-interferon levels is needed.
Subject(s)
Biomarkers, Tumor/blood , Cytokines/blood , Meningioma/diagnosis , Supratentorial Neoplasms/diagnosis , Female , Humans , Male , Middle AgedABSTRACT
To evaluate prospects of immunocorrection in the treatment of patients with supratentorial meningiomas, we studied blood serum levels of interleukins 2, 4, 6, 10, 17, interferons α, Β, γ, heat shock proteins HSP60, HSP70 using ELISA. A study included 32 patients with supratentorial meningiomas in the presurgical period and a control group of 38 patients with lumbar disc hernias. We found the multidirectional changes in the cytokine profile that demonstrated the existence of immune imbalance in patients with meningiomas. There was the increase in the levels of Β-interferon, HSP60, interleukin 6 with the simultaneous decrease in α- and γ-interferons levels. The imbalance of cytokines in patients with meningiomas can have a negative impact on a clinical picture of the disease and worsen results of surgical treatment of tumors. To prevent secondary infectious complications after surgery, we recommend to administer glucocorticoids to decrease levels of interleukin 6 and α-interferon in the presurgical period.
Subject(s)
Cytokines/blood , Meningeal Neoplasms/blood , Meningioma/blood , Supratentorial Neoplasms/blood , Biomarkers, Tumor/blood , Disease Progression , Female , Follow-Up Studies , Humans , Male , Meningeal Neoplasms/diagnosis , Meningioma/diagnosis , Middle Aged , Retrospective Studies , Supratentorial Neoplasms/diagnosisSubject(s)
Brain Injuries/psychology , Quality of Life , Adult , Aged , Brain Injuries/physiopathology , Cognition/physiology , Female , Follow-Up Studies , Humans , Male , Middle Aged , Motor Activity/physiology , Prognosis , Retrospective Studies , Time Factors , Trauma Severity Indices , Young AdultSubject(s)
Encephalomyelitis, Acute Disseminated , Administration, Oral , Anti-Inflammatory Agents/administration & dosage , Anti-Inflammatory Agents/therapeutic use , Brain/diagnostic imaging , Brain/pathology , Diagnosis, Differential , Encephalomyelitis, Acute Disseminated/diagnosis , Encephalomyelitis, Acute Disseminated/diagnostic imaging , Encephalomyelitis, Acute Disseminated/drug therapy , Female , Humans , Magnetic Resonance Imaging , Middle Aged , Nicergoline/administration & dosage , Nicergoline/therapeutic use , Nootropic Agents/administration & dosage , Nootropic Agents/therapeutic use , Pentoxifylline/administration & dosage , Pentoxifylline/therapeutic use , Piracetam/administration & dosage , Piracetam/therapeutic use , Prednisolone/administration & dosage , Prednisolone/therapeutic use , Tomography, X-Ray Computed , Vasodilator Agents/administration & dosage , Vasodilator Agents/therapeutic useABSTRACT
The spinal fluid activities of aspartate aminotransferase (AAT), alkaline phosphatase (AP), and gamma-gluthamyl transferase were studied in 32 patients with cerebral gliomas to clarify the diagnostic role of these enzymes. There were different changes in their activities in groups of patients with low-differential and differential gliomas. Its was ascertained that higher AAT activity was due to the fact that blood had entered spinal fluid; increased AP activity may be regarded to be an indicator of higher permeability of the blood-brain barrier.
Subject(s)
Alkaline Phosphatase/cerebrospinal fluid , Aspartate Aminotransferases/cerebrospinal fluid , Brain Neoplasms/enzymology , Glioma/enzymology , gamma-Glutamyltransferase/cerebrospinal fluid , HumansABSTRACT
The immune status was investigated in 38 patients with STM before and after surgery. Phasic changes were found: T-lymphopenia and elevated level of antibrain antibodies--before the operation, laboratory equivalents of immunodeficient state--on day 3-5, and signs of autoimmune cerebral damage--on day 15-18 after the operation. Preoperative neurosensibilization potentiated brain edema and complicated the course of postoperative period in patients with supratentorial meningiomas.
Subject(s)
B-Lymphocytes/immunology , Lymphopenia/immunology , Meningeal Neoplasms/immunology , Meningioma/immunology , Supratentorial Neoplasms/immunology , T-Lymphocytes/immunology , Autoantibodies/immunology , Humans , Time FactorsABSTRACT
The permeability of the blood-brain barrier was studied in 48 patients by examining the protein indices of cerebrospinal fluid. The types of changes in the indices were identified, which reflected the level of the permeability and correlate with good and poor postoperative outcomes. Possible ways of correcting hypertransudation across the barrier were defined.
