ABSTRACT
Groups of 48 males and 48 female rats were given diets containing 0 (control), 500, 2000 or 10,000 ppm Chocolate Brown HT for 2 years. These treatments had no adverse effect on mortality, body-weight gain, food or water consumption, haematology, renal function, serum constituents, organ weight or histopathology. From the incidence of tumours observed in the control and test animals it is concluded that Chocolate Brown HT did not exert any carcinogenic effect and that the no-untoward-effect level was 10,000 ppm.
Subject(s)
Azo Compounds/toxicity , Food Coloring Agents/toxicity , Naphthalenesulfonates/toxicity , Animals , Body Weight/drug effects , Diet , Female , Male , Organ Size/drug effects , Rats , Time FactorsABSTRACT
Groups of 48 male and 50 female mice were given drinking-water containing 0, 50, 250 or 1000 ppm diethyl carbonate for 83 weeks. There was no effect on mortality, rate of body-weight gain or the incidence of histopathological findings, including tumors. There were isolated differences between treated and control mice in the findings of the haematological examinations and in the liver weights of female mice but these were not considered to be related treatment. It is concluded that no carcinogenic effect could be detected and that the no-untoward-effect level is 1000 ppm (approx. 140 mg/kg/day).
Subject(s)
Diethyl Pyrocarbonate/toxicity , Formates/toxicity , Animals , Body Weight/drug effects , Diet , Diethyl Pyrocarbonate/analogs & derivatives , Female , Liver/drug effects , Male , Mice , Organ Size/drug effects , Time FactorsSubject(s)
Flavoring Agents/toxicity , Sulfhydryl Compounds/toxicity , Animals , Blood Cell Count , Body Weight , Eating , Female , Hematocrit , Hemoglobins/analysis , Male , Organ Size , RatsABSTRACT
Gentamycin concentration in the serum, pericardial fluid, auricle, valve and papillary muscles of 14 patients subjected to cardiac surgery was determined after intramuscular administration of 80 mg of the drug. Fifty to 140 minutes after administration the mean level in the serum was 6.0 mcg/ml, in the pericardial fluid 0.6 mcg/ml, in the auricle 5.8 mcg/g, while after 120 to 240 minutes in the valve 1.2--9.6 mcg/g and in the papillary muscles 2.0--3.6 mcg/g of gentamycin was measured. Consequently, an efficacious gentamycin concentration can be achieved in the cardiac tissues but not in the pericardial fluid which makes gentamycin excellently suited for the prevention and treatment of the infectious complications of heart operations.
