ABSTRACT
This article defines case management with an emphasis on the functions and providers of various case management models. Nursing Case Management delivery system is compared with several other models of case management. The potential role for the nurse practitioner in case management is discussed as well as ethical pitfalls that are attributed to various case management models.
Subject(s)
Models, Nursing , Patient Care Planning/standards , Continuity of Patient Care/standards , Ethics, Nursing , Humans , Job Description , Organizational Objectives , Patient Care Planning/organization & administration , Patient Care TeamABSTRACT
A reversed-phase high-performance liquid chromatography (HPLC) system was developed for the determination of the antineoplastic agents cytarabine and azacitidine. Separations were performed on an octadecylsilane column with a mobile phase of methanol-phosphate buffer pH 7.0 (5:95). The assay methods are suitable for bulk drugs and sterile powder formulations of the agents. Specificity in the presence of analogues and decomposition products was demonstrated. UV spectra of the components of interest were obtained in the HPLC effluent, and appropriate wavelengths were employed for the various analytes. Samples of azacitidine in various solutions were analyzed as a function of time by HPLC to determine the three first-order constants associated with its decomposition.
Subject(s)
Azacitidine/analysis , Cytarabine/analysis , Azacitidine/metabolism , Biotransformation , Chromatography, High Pressure Liquid , Cytarabine/metabolism , Drug Stability , Humans , Indicators and Reagents , Kinetics , Leukemia/drug therapy , Powders , Spectrophotometry, UltravioletABSTRACT
A silver-modified, normal-phase, high-performance liquid chromatographic system has been developed for prostaglanding bulk drugs and triacetin solutions. Silver nitrate present in the mobile phase results in high selectivity for cis/trans isomers with conventional silica columns. Prostaglandins were esterified with alpha-bromo-2'-acetonaphthone prior to chromatography to provide high detectability at 254 nm. For dilute triacetin solutions, a sample preparation scheme based on gravity-flow chromatography with silica columns was developed to isolate the prostaglandin from triacetin prior to derivatization. The analytical technique was applied to triacetin solutions containing as little as 10 micrograms/ml arbaprostil [15-(R)-methyl-PGE2].
