Subject(s)
Asthma/parasitology , Lung Diseases, Parasitic/diagnosis , Strongyloidiasis/diagnosis , Aged , Asthma/diagnosis , Asthma/drug therapy , Diagnosis, Differential , Female , Humans , Lung Diseases, Parasitic/drug therapy , Parasite Egg Count , Strongyloidiasis/drug therapy , Thiabendazole/therapeutic useSubject(s)
Drowning/prevention & control , Emergency Responders/education , Rescue Work , Swimming , Adolescent , Adult , Cardiopulmonary Resuscitation , Female , Humans , Male , Swimming Pools , Young AdultABSTRACT
INTRODUCTION The etiology of autoimmune hepatitis (AIH) is unclear, with molecular mimicry between host and viral/drug antigens being the most plausible mechanism initiating the immune cascade that induces hepatocyte injury. Finding a serologic parameter that closely relates to the liver histology would be beneficial for monitoring AIH activity and optimizing treatment. OBJECTIVES We studied serum interleukin (IL)-17 levels and IL17 activators (IL6 and transforming growth factor ß1 [TGF-ß1]) in treatment-naive and immunosuppressed patients with AIH. We also analyzed the relationships between these cytokines and histological inflammation scores. PATIENTS AND METHODS A total of 44 patients with confirmed AIH were enrolled to the study (22 treatment-naive patients and 22 patients in clinical remission after at least 3 years of immunosuppression). Liver biopsies were performed, and the histological grading of inflammatory activity was performed by a single pathologist. The control group comprised 30 healthy age- and sexmatched subjects. Serum IL17, IL6, and TGFß1 levels were measured by a quantitative sandwich enzyme immunoassay. RESULTS Serum IL17, IL6, and TGFß1 levels were higher in treatment-naive patients compared with controls (23.2 pg/ml vs 15.3 pg/ml, P = 0.0001; 5.20 pg/ml vs 1.42 pg/ml, P = 0.0001; and 40.5 ng/ml vs 30.1 ng/ml, P = 0.04; respectively). In treatment-naive patients, serum IL17 negatively correlated with hepatic inflammation (r = -0.63, P = 0.01). A reduced serum IL17 concentration correlated with an increased TGFß1 concentration in patients in clinical remission (r = -0.51, P = 0.03). CONCLUSIONS Serum IL17 levels may be a useful parameter for assessing disease activity in patients with AIH.