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Chemistry ; 14(30): 9305-11, 2008.
Article in English | MEDLINE | ID: mdl-18729115

ABSTRACT

A new group of quaternary ammonium lactate based ionic liquids have been prepared and characterized. Didecyldimethylammonium (DDA) and benzalkonium (BA) D,L- and L-lactates are air-stable, hydrophilic, surface-active salts. They are very effective antibacterial and antifungal agents, especially the DDA lactates, against Streptococcus mutants and Candida albicans. Their activities are comparable or more effective than the original benzalkonium chloride. In addition, they have been shown to be good insect-feeding deterrents. However, they are poor antifungal agents for wood preservation. The toxicity of the DDA and BA lactates has also been studied and the results are presented in this paper.


Subject(s)
Alkanes/chemistry , Ionic Liquids/chemistry , Lactic Acid/chemical synthesis , Lactic Acid/pharmacology , Quaternary Ammonium Compounds/chemistry , Animals , Bacteria/drug effects , Feeding Behavior/drug effects , Female , Fungi/drug effects , Insecta/physiology , Ionic Liquids/pharmacology , Ionic Liquids/toxicity , Lactic Acid/chemistry , Lactic Acid/toxicity , Lethal Dose 50 , Rats , Surface Properties , Wood/drug effects
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