1.
Clin Exp Hypertens
; 35(5): 355-60, 2013.
Article
in English
| MEDLINE
| ID: mdl-23072348
ABSTRACT
We enrolled 196 patients with hypertension who were already being treated with free-drug combinations of angiotensin-II receptor blocker (ARB) and amlodipine. The free-drug combinations of ARB and amlodipine were replaced with the same dose of the fixed-dose combinations. The average home blood pressure (BP) in all patients receiving fixed-dose combinations was significantly lower than those receiving free-drug combinations (131 ± 10/75 ± 8 vs. 136 ± 11/77 ± 9 mm Hg, P < .01) accompanied with increasing drug adherence. After lowering BP by fixed-dose combinations, the costs for medications decreased by 31% over the 3 months.
Subject(s)
Amlodipine/therapeutic use , Angiotensin Receptor Antagonists/therapeutic use , Calcium Channel Blockers/therapeutic use , Health Care Costs/statistics & numerical data , Hypertension/drug therapy , Hypertension/economics , Medication Adherence , Aged , Aged, 80 and over , Amlodipine/economics , Amlodipine/pharmacology , Angiotensin Receptor Antagonists/economics , Angiotensin Receptor Antagonists/pharmacology , Benzimidazoles/economics , Benzimidazoles/pharmacology , Benzimidazoles/therapeutic use , Benzoates/economics , Benzoates/pharmacology , Benzoates/therapeutic use , Biphenyl Compounds , Blood Pressure/drug effects , Blood Pressure/physiology , Blood Pressure Monitoring, Ambulatory , Calcium Channel Blockers/economics , Calcium Channel Blockers/pharmacology , Dose-Response Relationship, Drug , Drug Therapy, Combination , Female , Humans , Hypertension/physiopathology , Male , Middle Aged , Prospective Studies , Retrospective Studies , Telmisartan , Tetrazoles/economics , Tetrazoles/pharmacology , Tetrazoles/therapeutic use , Treatment Outcome , Valine/analogs & derivatives , Valine/economics , Valine/pharmacology , Valine/therapeutic use , Valsartan
2.
Nihon Rinsho
; 61 Suppl 4: 627-31, 2003 Apr.
Article
in Japanese
| MEDLINE
| ID: mdl-12735042
