ABSTRACT
18F-FDG whole-body positron emulsion tomography (18F-FDG PET) has become an established imaging modality for a variety of cancers. Today, 18F-FDG PET is utilized to differentiate benign from malignant non-functioning adrenal masses. In this report, a 25-year-old woman presented with a 2-month history of left flank pain. Abdominal CT revealed a left 6.5 x 4.5 cm adrenal mass with regular margins and focal calcification. To make a differential diagnosis, 18F-FDG PET was performed. Preoperative laboratory studies showed that the mass was non-functioning. A left adrenalectomy was performed through a left subcostal incision. The final pathologic evaluation revealed adrenal oncocytoma. We present the disassociation between preoperative 18F-FDG PET and pathologic findings of a benign adrenocortical oncocytoma.
Subject(s)
Adenoma, Oxyphilic/diagnostic imaging , Adenoma, Oxyphilic/pathology , Adrenal Gland Neoplasms/diagnostic imaging , Adrenal Gland Neoplasms/pathology , Positron-Emission Tomography/methods , Adenoma, Oxyphilic/surgery , Adrenal Gland Neoplasms/surgery , Adrenalectomy/methods , Adult , Diagnosis, Differential , False Positive Reactions , Female , Fluorodeoxyglucose F18 , Follow-Up Studies , Humans , Immunohistochemistry , Neoplasm Staging , Preoperative Care/methods , Treatment OutcomeABSTRACT
Monostotic Paget's disease of the patella was detected with Tc-99m MDP and Tl-201 scans. Diffuse intense uptake of MDP in the left patella was observed on the blood-pool and late phases of the bone scan. Tl-201 imaging was performed to differentiate a malignant process and showed diffuse marked accumulation at the same site. Semiquantitative analysis of the patella region on both Tc-99m MDP and Tl-201 scans did not support a diagnosis of cancer. Radiographs showed the features of Paget's disease of the bone. Findings of a pathologic evaluation were compatible with the diagnosis of osteitis deformans. This case represents the unusual skeletal involvement of monostotic Paget's disease of the bone in the patella. Tl-201 accumulation in the Paget's lesion was suggested to be caused by increased metabolic activity of the lesion but was not indicative of a malignant process.
Subject(s)
Osteitis Deformans/diagnostic imaging , Patella/diagnostic imaging , Thallium Radioisotopes , Aged , Bone Neoplasms/diagnosis , Diagnosis, Differential , Female , Humans , Radionuclide Imaging , Radiopharmaceuticals , Technetium Tc 99m MedronateABSTRACT
Ga-67 and abdominal CT scans of a 72-year-old woman who had malignant lymphoma before, during, and after gallium nitrate/hydroxyurea combination therapy are presented. Disappearance of Ga-67 uptake by the tumor during this treatment despite continuing CT evidence of disease and reappearance of Ga-67 scan abnormalities after cessation of therapy suggests that caution should be exercised when interpreting results of Ga-67 scintigraphy for the detection of tumor viability during gallium nitrate/hydroxyurea therapy.
Subject(s)
Antineoplastic Agents/therapeutic use , Gallium Radioisotopes , Gallium/therapeutic use , Hydroxyurea/therapeutic use , Leukemia, Lymphocytic, Chronic, B-Cell/diagnostic imaging , Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy , Aged , Antineoplastic Agents/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Female , Gallium/administration & dosage , Humans , Hydroxyurea/administration & dosage , Radionuclide Imaging , Tomography, X-Ray ComputedABSTRACT
A patient with parathyroid cancer is presented who underwent Tc-99m MIBI scintigraphy. The Tc-99m MIBI image demonstrated increased accumulation of activity at the lower pole of the left thyroid lobe which was later confirmed as a parathyroid cancer. Uptake by parathyroid cancer must be kept in mind as a cause of increased Tc-99m MIBI accumulation when a disease is in question in the thyroid or parathyroid gland.
