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1.
Clin Neurol Neurosurg ; 115(8): 1470-5, 2013 Aug.
Article in English | MEDLINE | ID: mdl-23485251

ABSTRACT

BACKGROUND: Angiogram negative sub-arachnoid haemorrhage (SAH) is generally considered to have a more benign course than SAH of known cause. There is also variability from centre to centre as to what proportion of angiogram negative SAH patients undergo repeat Digital Subtraction Angiography (DSA). We performed a retrospective study looking at the last four years' of SAH patients at our institution in order to ascertain the clinical course, the nature and results of repeat imaging. METHODS: Retrospective analysis of clinical records and imaging of all patients presenting to our institution with non-traumatic SAH between April 2008 and February 2012 was performed. Results were analysed for presenting grades, blood distribution, complications, outcomes, repeat imaging modalities and findings. RESULTS: 459 patients with proven non-traumatic SAH of which 50 (11%) had no vascular cause identified on their initial angiogram were identified. The blood distribution was perimesencephalic in 17, non-perimesencephalic in 23, and 10 patients were computed tomography (CT) Negative with a positive lumbar puncture. Eight (16%) patients were complicated by hydrocephalus and 2 (4%) were complicated by vasospasm. Eight patients (16%) underwent repeat cranial DSA with a high suspicion in a multi-disciplinary team setting. None of the repeat angiograms showed an underlying aetiology for the SAH. 76% of patients had a Glasgow Outcome Score of 5 at 6 months. There were no rebleeds. CONCLUSIONS: While generally more benign, angiogram negative subarachnoid haemorrhage can have a complicated clinical course. In our experience repeat DSA should be reserved for cases in which there is significant suspicion of occult vascular lesion. However, evidence-based guidelines are needed to aid the development of management protocols for angiogram-negative SAH and ensuring optimal patient outcomes.


Subject(s)
Angiography, Digital Subtraction/methods , Cerebral Angiography/methods , Subarachnoid Hemorrhage/diagnosis , Adult , Aged , Brain/diagnostic imaging , Brain/pathology , False Negative Reactions , Female , Follow-Up Studies , Glasgow Outcome Scale , Humans , Male , Middle Aged , Patient Care Team , Retrospective Studies , Spine/diagnostic imaging , Spine/pathology , Subarachnoid Hemorrhage/pathology , Tomography, X-Ray Computed , Treatment Outcome , Young Adult
2.
J Neurol Neurosurg Psychiatry ; 80(10): 1130-3, 2009 Oct.
Article in English | MEDLINE | ID: mdl-19535354

ABSTRACT

BACKGROUND: External lumbar drainage (ELD) is known as a good predictor of favourable outcome in shunting patients suffering from idiopathic normal pressure hydrocephalus (iNPH). METHODS: Eleven patients suffering from iNPH had a lumbar drain (LD) inserted for 72 h and participated in a research study to quantify any improvement in their clinical symptoms. The lumbar cerebrospinal fluid (CSF) levels of lactate, 8-isoprostane, vascular endothelial growth factor (VEGF), glial fibrillar acidic protein (GFAP), neurofilament (heavy chain) protein (NF (h)), Abeta(1-42) (beta-amyloid) and total tau were assayed samples from all three time points. RESULTS: The concentrations of lactate, VEGF, GFAP and tau increased significantly during the 72 h of drainage. There were also increases in 8-isoprostane and Abeta(1-42) (non significant). The concentration of NF (h) was reduced significantly following 72 h of drainage. There was a significant positive correlation between Abeta(1-42) and total tau in the first sample. GFAP was negatively correlated in a significant fashion with both Abeta(1-42) and total tau. NF (h) was negatively correlated with VEGF. CONCLUSION: Evidence is provided that ELD is producing measurable changes in the CSF composition of patients with iNPH. The present paper discusses how such changes may be implicated in the pathophysiology of the condition.


Subject(s)
Drainage , Hydrocephalus, Normal Pressure/cerebrospinal fluid , Hydrocephalus, Normal Pressure/therapy , Aged , Aged, 80 and over , Amyloid beta-Peptides/cerebrospinal fluid , Biomarkers/cerebrospinal fluid , Dinoprost/analogs & derivatives , Dinoprost/cerebrospinal fluid , Female , Glial Fibrillary Acidic Protein/cerebrospinal fluid , Humans , Hydrocephalus, Normal Pressure/physiopathology , Lactic Acid/cerebrospinal fluid , Longitudinal Studies , Male , Middle Aged , Neurofilament Proteins/cerebrospinal fluid , Peptide Fragments/cerebrospinal fluid , Spinal Puncture , Vascular Endothelial Growth Factor A/cerebrospinal fluid , tau Proteins/cerebrospinal fluid
3.
4.
Br J Neurosurg ; 22(6): 748-57, 2008 Dec.
Article in English | MEDLINE | ID: mdl-19085358

ABSTRACT

There has been a controversy in the last 15 years on the correct management of brain stem cavernomas. We have reviewed our experience of the last 10 years in a single Institution and reviewed related literature published in the last 15 years. We recorded the demographics, clinical presentation, rebleeding episodes, incidence of neurological events and outcome assessed by recording the change of the modified Rankin scale in 21 cases. Univariate analysis was applied to test the effect of demographics, and presentation on the incidence and timing of rebleeding, chance of having a new neurological event, the number of subsequent neurological events and outcomes. Six cases were treated with surgery and 15 cases were managed conservatively. We obtained follow-up data in 20 patients (95%). Mean follow-up period was 79.7 months (range: 6-244, median 70 months). There were 0.05 rebleeding events per patient-year and 0.1 episodes of neurological deterioration per patient-year. No mortality was noted in either the surgical or the non-surgical group. Three of the six surgical cases had a reoperation. The outcome was improved in one patient, unchanged in 1, and worse in 3 surgical patients. In the case of conservative management the outcome was improved in two patients, unchanged in five patients, and worse in eight patients. Outcome was worse in the case of multiple cavernomas (p = 0.012). Our findings suggest that conservative management may be appropriate in individual cases when compared with surgery, but this difference was not statistically significant enough in order to support a change in practice. The natural history of brain stem cavernomas appears more benign than previously thought.


Subject(s)
Brain Stem Neoplasms/therapy , Brain Stem/surgery , Cerebral Hemorrhage/therapy , Hemangioma, Cavernous, Central Nervous System/therapy , Adult , Brain Stem Neoplasms/complications , Brain Stem Neoplasms/surgery , Cerebral Hemorrhage/etiology , Cerebral Hemorrhage/surgery , Female , Hemangioma, Cavernous, Central Nervous System/complications , Hemangioma, Cavernous, Central Nervous System/surgery , Humans , Kaplan-Meier Estimate , Male , Neurologic Examination/statistics & numerical data , Recurrence , Time Factors , Treatment Outcome
6.
Neuropathol Appl Neurobiol ; 32(2): 217-20, 2006 Apr.
Article in English | MEDLINE | ID: mdl-16599951

ABSTRACT

We describe three unusual tumours characterized by a mixture of glial and neuronal differentiation, involvement of the posterior fossa and formation of rosettes. Mixed glial-neuronal tumours of the posterior fossa are rare and poorly described neoplasms. However, several distinctive entities have appeared in the literature over recent years under a variety of different names. Our cases demonstrate the morphological features of the 'rosette-forming glioneuronal tumour of the fourth ventricle', a recently identified tumour characterised by its unique location, neurocytic pseudo-rosette formation and the presence of a low grade astrocytoma component. The long term prognosis of these tumours remains unclear. However, the clinical data available including the cases presented here, along with the histological features, suggest that these are low grade tumours with a good prognosis after surgical resection.


Subject(s)
Cerebral Ventricle Neoplasms/pathology , Fourth Ventricle/pathology , Neuroglia/pathology , Adult , Astrocytoma/metabolism , Astrocytoma/pathology , Astrocytoma/physiopathology , Cerebral Ventricle Neoplasms/metabolism , Cerebral Ventricle Neoplasms/physiopathology , Female , Humans , Immunohistochemistry , Magnetic Resonance Imaging , Male , Neurocytoma/metabolism , Neurocytoma/pathology , Neurocytoma/physiopathology
7.
J Clin Pathol ; 58(9): 981-3, 2005 Sep.
Article in English | MEDLINE | ID: mdl-16126883

ABSTRACT

Inflammatory myofibroblastic tumours (IMTs) are an uncommon spindle cell neoplasm with a dense inflammatory infiltrate, usually encountered in children. IMTs of the central nervous system are extremely rare. This report describes the case of an IMT in a 61 year old man, in the pineal region. The tumour was completely excised, and immunohistochemistry demonstrated anaplastic lymphoma kinase 1 expression. There was no tumour recurrence during 18 months of follow-up. Our case extends both the age range and sites of occurrence of this rare tumour.


Subject(s)
Brain Neoplasms/enzymology , Neoplasms, Muscle Tissue/enzymology , Pineal Gland , Protein-Tyrosine Kinases/metabolism , Anaplastic Lymphoma Kinase , Brain Neoplasms/pathology , Brain Neoplasms/surgery , Humans , Male , Middle Aged , Neoplasms, Muscle Tissue/surgery , Receptor Protein-Tyrosine Kinases
10.
Br J Sports Med ; 38(4): E8, 2004 Aug.
Article in English | MEDLINE | ID: mdl-15273201

ABSTRACT

We report the case of a chronic subdural haematoma caused by repetitive heading of a football which led to the diagnosis of a middle fossa arachnoid cyst. The association between arachnoid cysts and subdural haematoma is discussed as are safety implications in sporting injuries.


Subject(s)
Arachnoid Cysts/complications , Craniocerebral Trauma/complications , Hematoma, Subdural, Chronic/complications , Soccer/injuries , Adult , Arachnoid Cysts/surgery , Headache/etiology , Hematoma, Subdural, Chronic/surgery , Humans , Nausea/etiology , Risk Factors , Tomography, X-Ray Computed/methods , Treatment Outcome , Vomiting/etiology
12.
Br J Neurosurg ; 17(5): 426-31, 2003 Oct.
Article in English | MEDLINE | ID: mdl-14635747

ABSTRACT

In the current climate of clinical governance and audit, and in the setting of an active academic unit, an effective clinical database is an invaluable tool. In this article, we will present our neurovascular database, discuss the issues related to setting up the ideal clinical database, discuss the problems related to accurate data input and review the legal requirements of data protection. The success of a clinical database is reflected by the completeness of the data, the accessibility of the information and how useful it has proven to be. After 4 years of experimentation we currently use a database designed on Microsoft Access. The form is a single page. Junior medical staff input the information as medical staff have been found to be the most reliable personnel for data input in terms of accuracy. However, time is generally in short supply amongst this group. For our purposes, the ideal database is one that is simple, that can be used to flag up cases, rather than provide all of the information and ensures a complete dataset. The arrival of the UK 1998 Data Protection Act has put many clinical databases and registries in jeopardy, and introduced further bureaucracy to research. We discuss the Act and its interpretation by the General Medical Council, Medical Research Council, British Medical Association, Department of Health and our own trust with respect to databases and research.


Subject(s)
Cerebrovascular Disorders/therapy , Computer Security/legislation & jurisprudence , Databases, Factual/legislation & jurisprudence , Computer Security/standards , Confidentiality , Databases, Factual/standards , Hospitals , Humans , Medical Audit , Research , State Medicine , United Kingdom
13.
Minim Invasive Neurosurg ; 46(4): 254-6, 2003 Aug.
Article in English | MEDLINE | ID: mdl-14506573

ABSTRACT

Stereotactic radiosurgery has been proposed as the first line treatment for acoustic tumours and has been particularly advocated in cases of Type 2 Neurofibromatosis (NF2) with bilateral acoustic nerve tumours. We present the case of a 22-year-old male with NF2 and bilateral acoustic nerve tumours. He underwent an uncomplicated excision of the larger, left sided lesion. Histology showed a benign acoustic schwannoma with no atypical features. One year later he underwent stereotactic radiosurgery (Gamma Knife 1500 cGy) to the right sided lesion. After initial swelling, within 12 months the tumour had reduced in size and undergone central necrosis. However, 2 years later MRI of the brain revealed a dramatic increase in the size of the right sided tumour, with considerable brain stem compression. The patient subsequently died. This highly unusual case highlights the need for careful clinical and radiological follow up. in patients with acoustic tumours, regardless of the treatment method employed.


Subject(s)
Neoplasm Recurrence, Local , Neuroma, Acoustic/pathology , Neuroma, Acoustic/surgery , Radiosurgery , Adult , Disease Progression , Fatal Outcome , Humans , Magnetic Resonance Imaging , Male , Neurofibromatosis 2/complications
14.
Br J Neurosurg ; 16(3): 243-55, 2002 Jun.
Article in English | MEDLINE | ID: mdl-12201394

ABSTRACT

The objective of this study was to determine the current level of patient satisfaction with neurosurgical services from the time of initial referral to hospital discharge. The survey was camed out by a self-administered postal questionnaire survey from the National Hospital for Neurology and Neurosurgery, London, UK. The participants were 364 patients discharged from the unit within one calendar year. The main outcome measures were level of satisfaction with various aspects of care, as measured by fixed response and free text style questions. Most patients are happy with the waiting time to see a neurosurgeon and the wait for subsequent admission acceptable, but many would have preferred it to be shorter. Twenty-seven had their original admission date cancelled, but most were happy with the explanation offered. Weaknesses in the management of outpatient clinics were highlighted, 35% of patients waiting more than half an hour to be seen. The great majority were happy with various aspects of communication with the neurosurgical team. Few patients were given the opportunity to follow up their visit with literature provided or a visit to a specialist nurse (17 and 9%, respectively). However, both were considered very useful, in particular, 93% highly valued a meeting with the specialist nurse. There was a dichotomy of opinion over the course of the inpatient stay. While most aspects of care received 70-80% satisfaction, the management of discharge received the most criticism. This was thought to represent a pooling of resources around the most needy patients. The majority of patients were discharged home (76%), only a third feeling that staff did everything possible to help this process. Very few received printed information. Again, those who had seen the specialty nurse had much higher levels of satisfaction. Patient satisfaction audit gives useful data on patients' perception and satisfaction with care that may not be apparent on more traditional audit measures such as length of stay, which focus more on a unit's efficiency. This study shows generally high levels of patient satisfaction with neurosurgical practice but highlights areas needing attention and expansion, such as access to a specialist nurse and relevant literature. Dissatisfaction with various administrative arrangements are clearly shown and provide an opportunity for patient centred improvements.


Subject(s)
Neurosurgical Procedures/standards , Patient Satisfaction , Surgery Department, Hospital/standards , Adult , Aged , Aged, 80 and over , Ambulatory Care/standards , Family Practice , Female , Humans , Male , Medical Audit , Middle Aged , Patient Care Team , Patient Education as Topic , Physician-Patient Relations , Surveys and Questionnaires
15.
Minim Invasive Neurosurg ; 44(3): 157-62, 2001 Sep.
Article in English | MEDLINE | ID: mdl-11696885

ABSTRACT

Although the treatment of colloid cysts remains controversial, high viscosity and small volume are poor prognostic indicators for successful burr hole aspiration and cortical incision via craniotomy may be associated with postoperative epilepsy. The anterior transcallosal approach provides a direct and adequate pathway to the lateral ventricles, where the foramen of Monro serves as a natural entrance into the anterior third ventricle, especially when the foramen is dilated by a lesion. When the midsuperior portion of the IIIrd ventricle cannot be reached, the interforniceal or the subchoroidal exposures have been advocated. Stereotactic techniques contribute to a minimal invasive approach and reduce morbidity. Nine patients harbouring anterior third ventricular cysts (seven colloids and two intrinsic craniopharyngiomas) underwent anterior transcallosal microsurgical excision assisted by an interactive infrared-based image guided system (EasyGuide, Neuro, Philips). There were 4 men and 5 women ranging in age from 15 to 42 years (mean 28.5). Transcallosal transforaminal (5 cases) or interforniceal (4 cases) approaches allowed total excision in eight patients and subtotal in one. Postoperative morbidity included a case of transient hemiparesis and a case of transient short-term memory disturbances; both resolved in the first months. Mortality was zero. Particular advantages of the method were accurate trajectory and position of callosotomy incision determination, visualisation and avoidance of superior saggital sinus, retraction of bridging veins and the often variable pericallosal arteries, spatial orientation within the ventricular system, and identification of the periventricular anatomical structures.


Subject(s)
Corpus Callosum/surgery , Cysts/surgery , Image Processing, Computer-Assisted/instrumentation , Microsurgery/instrumentation , Stereotaxic Techniques/instrumentation , Surgery, Computer-Assisted/instrumentation , Third Ventricle/surgery , Adolescent , Adult , Craniopharyngioma/surgery , Female , Humans , Magnetic Resonance Imaging/instrumentation , Male , Pituitary Neoplasms/surgery , Postoperative Complications/etiology , Software , Tomography, X-Ray Computed/instrumentation
16.
J Neurosurg Sci ; 45(2): 103-9, 2001 Jun.
Article in English | MEDLINE | ID: mdl-11533535

ABSTRACT

A rare case of a giant, temporo-occipital sinus pericranii is presented. A 38-year-old male presented with minor symptoms of headache and heaviness over an enlarging temporo-occipital bone defect. Within the defect a soft, compressible, mass lesion was observed, which varied in size with changes in intracranial pressure. Radiological imaging demonstrated bone erosion around a fluid filled mass, which on angiography communicated via a series of channels with the transverse sinus. A diagnosis of sinus pericranii was made. Due to the risk of future complication the patient elected to undergo surgery, which successfully resected the mass and obliterated the venous communications with the diploic veins and transverse sinus. The classification, aetiology, differential diagnosis, radiological characteristics and management options relating to sinus pericranii are discussed.


Subject(s)
Cranial Sinuses/pathology , Sinus Pericranii/pathology , Skull/pathology , Adult , Brain/blood supply , Brain/diagnostic imaging , Brain/pathology , Cranial Sinuses/diagnostic imaging , Cranial Sinuses/surgery , Diagnosis, Differential , Humans , Intraoperative Complications/etiology , Intraoperative Complications/surgery , Magnetic Resonance Imaging , Male , Sinus Pericranii/diagnostic imaging , Sinus Pericranii/surgery , Skull/blood supply , Skull/diagnostic imaging , Tomography, X-Ray Computed , Treatment Outcome
17.
Ann R Coll Surg Engl ; 83(4): 292-4, 2001 Jul.
Article in English | MEDLINE | ID: mdl-11518386

ABSTRACT

Internet has recently evolved as a versatile and influential repository of information including those pertaining to neurosurgery. This study was undertaken to find out whether there is good quality information currently available on the Internet for neurosurgery patients and their families. We surveyed the World Wide Web (www) for information on 5 neurosurgery-terms: pallidotomy, lumbar discectomy, hydrocephlus, glioma and carotid artery aneurysm. We searched the www using Google search-engine for documents related to each of the above terms and then assessed the information contained in the first 30-hits for each term using a simple 4-point grading system. Our study suggests that there is generally a good quantity of good quality information on the Internet for neurosurgery patients and their families. Internet provides an opportunity for patient associations and professional bodies to collaborate to create useful databases to help neurosurgery patients and their relatives.


Subject(s)
Information Services/standards , Internet/standards , Neurosurgery , Patient Education as Topic/standards , Humans , Neurosurgical Procedures , Patient Education as Topic/methods
18.
J Neurosurg ; 94(5): 728-32, 2001 May.
Article in English | MEDLINE | ID: mdl-11354403

ABSTRACT

OBJECT: Several factors are known to increase the risk of subarachnoid hemorrhage (SAH) and spontaneous intracerebral hematoma. However, information on the roles of these same factors in the formation of multiple aneurysms is less well defined. The purpose of this study was to examine factors associated with an increased risk of multiple aneurysm formation. METHODS: A retrospective review of the medical records of all patients with a diagnosis of SAH and intracranial aneurysms who were admitted to a single institution between 1985 and 1997 was undertaken. The authors examined associations between risk factors (patient age and sex, menopausal state of female patients, hypertension, cigarette smoking, alcohol consumption, history of cardiovascular disease or diabetes mellitus, and family history of cerebrovascular disease) and the presence of multiple aneurysms by using the Fisher exact test and logistic regression analysis. Of 400 patients admitted with a diagnosis of cerebral aneurysms, 392 were included in the study (287 women and 105 men). Two hundred eighty-four patients harbored a single aneurysm and 108 harbored multiple aneurysms (2 aneurysms in 68 patients, three aneurysms in 22 patients, four aneurysms in 13 patients, and five aneurysms in five patients). CONCLUSIONS: Statistical analysis revealed that, as opposed to the occurrence of a single aneurysm, there was a significant association between the presence of multiple aneurysms and hypertension (p < 0.001), cigarette smoking (p < 0.001), family history of cerebrovascular disease (p < 0.001), female sex (p < 0.001), and postmenopausal state in female patients (p < 0.001).


Subject(s)
Intracranial Aneurysm/epidemiology , Adult , Age Distribution , Aged , Alcohol Drinking , Cerebral Angiography , Family Health , Female , Humans , Hypertension/epidemiology , Intracranial Aneurysm/diagnosis , Male , Middle Aged , Postmenopause , Retrospective Studies , Risk Factors , Sex Distribution , Smoking/epidemiology , Subarachnoid Hemorrhage/diagnosis , Subarachnoid Hemorrhage/epidemiology
19.
Brain ; 124(Pt 1): 167-75, 2001 Jan.
Article in English | MEDLINE | ID: mdl-11133796

ABSTRACT

Visual inspection and volumetric analysis of MRIs allow mesial temporal sclerosis (MTS) to be reliably identified in patients with temporal lobe epilepsy. The presence of unilateral MTS ipsilateral to the side of habitual seizure onset is an indicator for the prognosis of good outcome after temporal lobe resection. There is evidence to suggest that widespread temporal lobe pathology, leading to atrophy, may be associated with MTS and such abnormal tissue may play an important role in epileptogenesis. We have analysed quantitatively the volumes of the mesial and lateral temporal lobe substructures in MRIs from 62 patients with intractable mesial temporal lobe epilepsy and in 20 normal controls. We found significant atrophy in these structures in patients, ranging from 8.3 to 18.4% compared with controls. The degree of atrophy in the extrahippocampal structures correlated with the degree of hippocampal atrophy, suggesting that a common process may be responsible. There was no correlation between the degree of atrophy in the extrahippocampal structures and the duration of epilepsy, a history of febrile convulsions or of generalized seizures. These findings suggest that there may be widespread pathological abnormalities in the temporal lobe associated with MTS. The importance of extrahippocampal atrophy to surgical outcome and whether it occurs in temporal lobe epilepsy not associated with MTS remain to be investigated.


Subject(s)
Atrophy/diagnosis , Epilepsy, Temporal Lobe/pathology , Hippocampus/pathology , Sclerosis/pathology , Temporal Lobe/pathology , Adult , Atrophy/complications , Epilepsy, Temporal Lobe/complications , Epilepsy, Temporal Lobe/etiology , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Predictive Value of Tests , Sclerosis/complications
20.
Amino Acids ; 21(3): 237-41, 2001.
Article in English | MEDLINE | ID: mdl-11764404

ABSTRACT

Mild hyperhomocysteinaemia is a postulated risk factor for occlusive vascular disease, including stroke. Subarachnoid haemorrhage (SAH) has an annual incidence of 10-20 per 100,000 and accounts for 5-10% of all strokes. Measurement of plasma total homocysteine (tHcy) in a cohort of vitamin B12 and folate replete patients did not reveal any association between tHcy and the aetiology of SAH.


Subject(s)
Homocysteine/blood , Subarachnoid Hemorrhage/blood , Adult , Aged , Aged, 80 and over , Case-Control Studies , Cross-Sectional Studies , Female , Folic Acid/blood , Humans , Incidence , Male , Middle Aged , Prospective Studies , Subarachnoid Hemorrhage/epidemiology , Vitamin B 12/blood
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