ABSTRACT
OBJECTIVE: To report the use of therapeutic plasma exchange (TPE) in a dog with carprofen toxicosis. SUMMARY: A 6-year-old female neutered Bichon Frise weighing 6.9 kg was examined after it had ingested 72 mg/kg carprofen. Mild dehydration without azotemia and with a urine specific gravity of 1.050 was noted at presentation. Treatment consisted of induction of emesis, symptomatic medical therapy, and TPE. The TPE achieved 1.5 plasma volume exchanges over 3 hours. Blood samples and effluent samples were collected every 30 minutes during TPE and additional blood samples were collected 11 and 35 hours after treatment. Carprofen concentrations in these samples were determined by high-pressure liquid chromatography. A 51% reduction in serum carprofen concentration was achieved following TPE. NEW OR UNIQUE INFORMATION PROVIDED: This report describes the successful reduction of plasma carprofen concentration in a dog using TPE. Although recent studies suggest that this particular dog may not have received a toxic dose, a 51% reduction of plasma carprofen concentration was achieved over 180 minutes, and TPE may be beneficial for treatment of dogs that have ingested higher doses.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/poisoning , Carbazoles/poisoning , Dog Diseases/diagnosis , Drug Overdose/veterinary , Animals , Diagnosis, Differential , Dog Diseases/blood , Dog Diseases/therapy , Dogs , Drug Overdose/diagnosis , Drug Overdose/therapy , Female , Plasma Exchange/veterinaryABSTRACT
Seven dogs diagnosed with enteropathogenic Escherichia coli (EPEC) infection in association with acute gastroenteritis are described. Disease severity ranged from mild in adults to fatal disease in young dogs. Enteropathogenic E. coli infection should be considered as a possible differential diagnosis in dogs with diarrhea.
Infection parEscherichia colientéropathogène (ECEP) en association avec une gastroentérite aiguë chez 7 chiens de la Saskatchewan. On décrit sept chiens diagnostiqués avec une infection par Escherichia coli entéropathogène (ECEP) en association avec une gastroentérite aigüe. La gravité de la maladie allait de légère chez les adultes à une maladie mortelle chez les jeunes chiens. E. coli entéropathogène devrait être considéré comme un diagnostic différentiel chez les chiens souffrant de la diarrhée.(Traduit par Isabelle Vallières).
