Litomosoides carinii: macrofilariae-derived glycolipids--chromatography, serology and potential in the evaluation of anthelminthic efficacy.

A preliminary characterization of the glycolipids of Litomosoides carinii macrofilariae, resolved according to their chromatographic, chemical and serological properties, has been performed. Emphasis has been placed on the neutral fraction glycolipids. These are separable on thinlayer chromatography into two groups of fast and slow migrating band components, that differ in their migration, differential chemical staining and serological traits, respectively. Serological analyses have been accomplished by thin-layer chromatography immunostaining and ELISA. Only components of the slow migrating band group react with infection serum from Litomosoides carinii-infected Mastomys coucha. Cross-reactivity experiments with homologous and heterologous infection sera of various helminthiases indicate that, epitopes bound to the neutral glycolipid fraction show structural similarity within the Nematoda, but not to the Cestoda or Trematoda. The dynamic development of specific Ig-, IgG- and IgM-anti-neutral glycolipid fraction antibody levels were correlated with the different progression of L. carinii and Brugia malayi infections in the multimammate rat, Mastomys coucha. The reduction in the dynamics of IgG- and IgM-antibody levels on chemotherapeutic treatment with the filaricides flubendazole and CGP 20376 has been related to their macrofilaricide-activity.

[Treatment of peyronie's disease with para-aminobenzoacidic potassium (POTOBA) (author's transl)]. / Zur Behandlung der Induration penis plastica mit para-aminobenzoesaurem Kalium (PABK).

A total of 214 urologists treated 2653 cases of Peyronie's Disease with para-aminobenzoacidic potassium (POTOBA). The treatment was successful in 57.3% and unsuccessful in 42.7% of the cases; 246 patients (9.3%) were 'cured. Particular prescriptions intended to increase gastric tolerance and thereby guarantee long-term use of the medication are pointed to as a prerequisite to successful therapy. Practical advice is presented on how to interest patients in carrying out long-term treatment themselves.