ABSTRACT
17α-Ethinylestradiol (EE2) is a frequently used drug and an endocrine disruptive substance. Adverse effects on biota have been reported when they are exposed to this substance in the environment. The last review on EE2 in the environment was published in 2014. Since then, well above 70 studies on EE2 and related substances have been published. The aim of this review was therefore to bring together recent data with earlier ones. The topics emphasized were observable trends of environmental levels of EE2 and methods to reduce EE2 levels in wastewater, before it can enter the environment. This should give an overview of the recent knowledge and developments regarding these environmental aspects of EE2. In the studies discussed, EE2 levels in surface waters were well detectable in many countries, both above and below the predicted no effect concentration (PNEC) of 0.035 ng L-1, although analytical methods used for the quantification often are unsatisfactory regarding their limit of detection. To support the degradation of EE2 prior to entry into the environment, appropriate treatment methods could help to control the emissions of EE2. Several methods for the reduction of EE2 levels of up to 100% removal efficiency were reported recently and are of chemical, biological, adsorptive or ion-exchange nature. Depending on the required properties like initial EE2 concentration or treatment duration, several promising methods are available.
