ABSTRACT
PURPOSE: We compared response, survival and side effects of regiments with intravenous cyclophosphamide followed by intraperitoneal cisplatin versus intravenous cyclophosphamide followed by intraperitoneal carboplatin as second line treatment in one center retrospective study. MATERIAL AND METHODS: Inclusion criteria were: relapse or recurrence of the disease after surgery and first line treatment; stage III histologicaly documented serous epithelial ovarian cancer after one or more prior regiments of chemotherapy. Recurrence were confirmed throughout restaging laparotomy or second look laparotomy. Patients from one of the groups received 90 mg/m(2) cisplatin on the first day and 750 mg/m(2) cyclophosphamide intravenously, while the second group members AUC 6 carboplatin intraperitoneally and 750 mg/m(2) cyclophosphamide intravenously. Four courses were administrated for each patient. RESULTS: Of the 49 patients in the cisplatin group the response rates were 21 (43%), 10 (20%) and 18 (37%) in the groups of pathologic complete response, pathologic partial response and progressive disease, respectively. The median survival from the initiation of intraperitoneal chemotherapy was 59 months. Of the 25 patients in the carboplatin group the response rates were 10 (40%), 4 (16%) and 11 (44%) respectively. The median survival -51 months. The differences between the groups were not statistically significant p>0.05 either in response or in toxicity. CONCLUSIONS: The results of our research including relatively long survival from intraperotoneal chemotherapy initiation confirm that carboplatin treatment is as good as cisplatin in second line intraperitoneal chemotherapy for ovarian cancer.
Subject(s)
Carboplatin/therapeutic use , Cisplatin/therapeutic use , Cyclophosphamide/therapeutic use , Neoplasms, Glandular and Epithelial/drug therapy , Ovarian Neoplasms/drug therapy , Adult , Aged , Carboplatin/administration & dosage , Carcinoma, Ovarian Epithelial , Cisplatin/administration & dosage , Cyclophosphamide/administration & dosage , Female , Humans , Middle Aged , Treatment Outcome , Young AdultABSTRACT
Carcinoma of the Bartholin's gland is a rare lesion accounting for only 5% of all vulvar cancers. Initial diagnosis of Bartholin's gland cancer (BGC) and recurrence after primary radical surgery and adjuvant radiotherapy poses a challenge in the treatment of BGC. This case report presents a particularly aggressive course of BGC. Spontaneous rupture of the femoral artery in the postoperative period was observed. The length of the survival period from the moment of diagnosis amounted to less than 16 months. Aspects of initial diagnosis problem and treatment options in groin recurrence of vulvar carcinoma and vascular complications are discussed.
Subject(s)
Bartholin's Glands , Carcinoma/diagnosis , Vulvar Neoplasms/diagnosis , Disease Progression , Fatal Outcome , Female , Femoral Artery , Humans , Middle Aged , Neoplasm Recurrence, Local/surgery , Rupture, Spontaneous , Vascular Diseases/etiologyABSTRACT
OBJECTIVES: The aim of this study was to characterise group of patients with borderline tumours undergoing surgical treatment. DESIGN: The analysis included 83 patients with ovarian tumours of borderline malignancy at stage Ia, operated in the Gynaecological Department of Medical University of Gdansk between 1978-1997. The study takes into account comparison of: age of patients, type of surgery, tumour pathology, post surgical treatment. Furthermore, long term follow up was assessed. RESULTS: In the group of 83 patients with stage Ia 37 ware treated with conservative surgery, 46 underwent radical treatment. Postsurgical chemical treatment was not applied. Three patients had to be reoperated because of neoplasm disease recurrence. 8 patients were died from reasons not connected with main disease. CONCLUSIONS: Conservative surgery is proper treatment for young women with borderline ovary tumours in stage Ia. For older, perimenopausal women TAH with BSO without additional chemotherapy is suggested.
Subject(s)
Neoplasm Recurrence, Local/surgery , Ovarian Neoplasms/pathology , Ovarian Neoplasms/surgery , Adolescent , Adult , Female , Follow-Up Studies , Humans , Middle Aged , Neoplasm Staging , Reoperation , Retrospective StudiesABSTRACT
Pulmonary embolism during pregnancy is infrequent but serious complication. We report a case of 32-year old women at 31-st gestational week with massive pulmonary embolism. The management of the case and the review of current literature are presented. Our experience demonstrates the importance of interdisciplinary care.
Subject(s)
Pregnancy Complications, Cardiovascular/diagnosis , Pulmonary Embolism/diagnosis , Adult , Female , Humans , Patient Care Team , Pregnancy , Pregnancy Complications, Cardiovascular/drug therapy , Pregnancy Trimester, Third , Pulmonary Embolism/drug therapy , Severity of Illness IndexABSTRACT
Preterm labor is the most frequent complication of twin gestation. Between 1988-1998, 123 twin pregnancies complicated by preterm labor were observed. Complications during pregnancy, mode of delivery, neonatal outcomes, mortality and morbidity were presented. We compared our outcomes to data from current literature.
Subject(s)
Infant, Premature , Twins , Adult , Cesarean Section/statistics & numerical data , Delivery, Obstetric/statistics & numerical data , Female , Fetal Death , Humans , Infant, Newborn , Labor Presentation , Obstetric Labor, Premature/epidemiology , Parity , Poland , Pregnancy , Pregnancy Complications/epidemiology , Pregnancy Outcome , Retrospective StudiesABSTRACT
We report two cases of pregnancy in patients with multiple sclerosis. Both of women were primigravidas. In both cases pregnancy were ended by cesarean section: in first case due to obstetric indications, in second due to neurological indications. Our experience and a review of current literature are presented.
Subject(s)
Multiple Sclerosis/diagnosis , Pregnancy Complications/diagnosis , Adult , Female , Humans , Multiple Sclerosis/psychology , Pregnancy , Pregnancy Complications/psychologyABSTRACT
Systemic Lupus Erythematosus (SLE) during pregnancy may cause serious complications in the mother and fetus. We report a case of pregnancy in 23 years old woman with SLE. Pregnancy was complicated with spontaneous abortion and septic shock. Furthermore in our paper we discussed contraceptive methods proper for women with SLE. The choice of an optimal contraceptive method (OC) therapy is a significant problem in female SLE patients. In view of the influence of sex hormones on the evolution of SLE, oral contraceptive (OC) therapy has to be efficient, reversible and safe, without aggravating disease activity and causing metabolic and vascular side effects. As regards oral contraceptives, all authors agree that oestrogen-progestin combination pills are harmful, but the best alternative hormonal contraception remains to be determined. The management of the case and the review of current literature are presented. Our experience demonstrates the importance of interdisciplinary care.
Subject(s)
Abortion, Spontaneous/diagnosis , Contraceptives, Oral/administration & dosage , Lupus Erythematosus, Systemic/diagnosis , Pregnancy Complications/diagnosis , Adult , Escherichia coli Infections/complications , Female , Humans , Pregnancy , Severity of Illness Index , Shock, Septic/diagnosis , Shock, Septic/etiologyABSTRACT
DESIGN: The aim of the study was to describe pregnancies, deliveries, and puerperal times, and to compare them with the reached scientific communications. MATERIAL AND METHODS: Four pregnancies in women with the hypothyroidism were described. All cases were taken from the group of twenty pregnancies (18 women) who were treated because of thyroid gland diseases in our clinic. RESULTS: We found that every infant was born in good condition, deliveries and childbeds were uncomplicated. CONCLUSIONS: Our notices are similar to new scientific communications, that hypothyroidism coexists with pregnancy much often then everybody, till now, suspected and infants have not so often congenital defects.
