The cortical dynamics of intelligible speech.

An important and unresolved question is how the human brain processes speech for meaning after initial analyses in early auditory cortical regions. A variety of left-hemispheric areas have been identified that clearly support semantic processing, although a systematic analysis of directed interactions among these areas is lacking. We applied dynamic causal modeling of functional magnetic resonance imaging responses and Bayesian model selection to investigate, for the first time, experimentally induced changes in coupling among three key multimodal regions that were activated by intelligible speech: the posterior and anterior superior temporal sulcus (pSTS and aSTS, respectively) and pars orbitalis (POrb) of the inferior frontal gyrus. We tested 216 different dynamic causal models and found that the best model was a "forward" system that was driven by auditory inputs into the pSTS, with forward connections from the pSTS to both the aSTS and the POrb that increased considerably in strength (by 76 and 150%, respectively) when subjects listened to intelligible speech. Task-related, directional effects can now be incorporated into models of speech comprehension.

A randomized controlled clinical trial of psychoanalytic psychotherapy for panic disorder.

OBJECTIVE: The purpose of this study was to determine the efficacy of panic-focused psychodynamic psychotherapy relative to applied relaxation training, a credible psychotherapy comparison condition. Despite the widespread clinical use of psychodynamic psychotherapies, randomized controlled clinical trials evaluating such psychotherapies for axis I disorders have lagged. To the authors' knowledge, this is the first efficacy randomized controlled clinical trial of panic-focused psychodynamic psychotherapy, a manualized psychoanalytical psychotherapy for patients with DSM-IV panic disorder. METHOD: This was a randomized controlled clinical trial of subjects with primary DSM-IV panic disorder. Participants were recruited over 5 years in the New York City metropolitan area. Subjects were 49 adults ages 18-55 with primary DSM-IV panic disorder. All subjects received assigned treatment, panic-focused psychodynamic psychotherapy or applied relaxation training in twice-weekly sessions for 12 weeks. The Panic Disorder Severity Scale, rated by blinded independent evaluators, was the primary outcome measure. RESULTS: Subjects in panic-focused psychodynamic psychotherapy had significantly greater reduction in severity of panic symptoms. Furthermore, those receiving panic-focused psychodynamic psychotherapy were significantly more likely to respond at treatment termination (73% versus 39%), using the Multicenter Panic Disorder Study response criteria. The secondary outcome, change in psychosocial functioning, mirrored these results. CONCLUSIONS: Despite the small cohort size of this trial, it has demonstrated preliminary efficacy of panic-focused psychodynamic psychotherapy for panic disorder.

Psychometric characteristics of the conceptions of mathematics questionnaire.

This study describes the psychometric characteristics of the 19-item Conceptions of Mathematics Questionnaire for a total of 158 students (86 women and 72 men). The coefficient alpha of internal consistency reliability was .75. Principal components analysis with varimax rotation indicated a two-component solution could be extracted. The two theoretically meaningful dimensions were fragmented conceptions (alpha = .80) and cohesive conceptions (alpha = .80). The former entails seeing mathematics as number rules and formulae to be used to solve problems. Students who hold this conception use rote learning and memorization. In contrast, the latter entails seeing mathematics as a complex logical system for solving complex problems. Students with such a conception approach learning to attain, develop, and apply knowledge.

Clinical efficacy of methylphenidate in conduct disorder with and without attention deficit hyperactivity disorder.

BACKGROUND: Stimulants are not considered appropriate for the treatment of children with conduct disorders (CDs). The postulated differences in stimulant effect between children with attention deficit hyperactivity disorder (ADHD) and CD led to the hypothesis that methylphenidate hydrochloride, which is effective in ADHD, would not significantly improve symptoms of CD. METHODS: We randomly assigned 84 children with CD, between the ages of 6 and 15 years, to receive methylphenidate hydrochloride (up to 60 mg/d) or placebo for 5 weeks. Behavior was evaluated by parent, teacher, and clinician reports and by direct classroom observations. Two thirds of the children also met criteria for ADHD. RESULTS: Contrary to prediction, ratings of antisocial behaviors specific to CD were significantly reduced by methylphenidate treatment. The magnitude of methylphenidate effect indicated meaningful clinical benefit. Partialling out severity of ADHD did not alter the significant superiority of methylphenidate on CD ratings specifically (P < .001). CONCLUSIONS: Methylphenidate has short-term positive effects on children and adolescents with CD. Key aspects of antisocial adjustment appear to be treatment responsive. This effect was independent of severity of the children's initial ADHD symptoms.

[Calculation of the effective dose in human external irradiation with photons and neutrons]. / Raschet éffektivnoi dozy pri vneshnem obluchenii cheloveka fotonami i neitronami.

The method of calculation of the effective dose equivalent for external neutron and photon radiation are presented. Adjoint transport Monte-Carlo code ROBOT is used to calculate fluence-to-effective dose conversion function for MIRD phantoms. Two broad neutron and photon beam irradiations were chosen frontally and isotropically. The effective dose conversion functions are presented and good agreement is shown with Monte-Carlo calculation by other authors. The received data can be used in a new rates of radiation safety.

DSM-III-R personality diagnoses in anxiety disorder patients.

This study compared clinical characteristics of anxiety disorder patients with and without a co-occurring diagnosis of personality disorder. A structured diagnostic interview for anxiety disorders was used to make DSM-III-R diagnoses and to derive clinical ratings. The personality diagnosis group (n = 27) was compared with a large clinical series of anxiety disorder patients (n = 288) and with a group of patients without personality diagnoses who were matched on primary anxiety diagnosis, sex, and age (n = 25). The personality diagnosis group received significantly more diagnoses of current dysthymia and past major depression. The personality diagnosis group also had a significantly higher rate of rare anxiety disorders than the clinical series and significantly lower ratings of current adaptive functioning than the matched controls. These findings, suggesting the presence of a group of anxiety disorder patients with significant personality and affective symptomatology, are discussed in terms of models of syndrome-personality comorbidity and treatment response.