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1.
J Pediatr Surg ; 35(6): 923-6, 2000 Jun.
Article in English | MEDLINE | ID: mdl-10873036

ABSTRACT

BACKGROUND/PURPOSE: Controversy persists in the management of perforated appendicitis with regard to antibiotic choice and duration, operative timing, drain utilization, and wound closure. For 2 decades at the authors' institution, patients were treated with ampicillin, gentamicin, and clindamycin for 10 inpatient days, with drains in the abdomen, resulting in lower complication rates than most other published series. Managed care pressures have led to less aggressive medical management regimens with length of stay and financial factors viewed as principal outcome measures with little emphasis on clinical outcomes. In addition, there are little prospective data on clinical outcomes. The authors sought to determine whether our previously documented excellent quality outcomes could be maintained when modifications aimed at decreasing cost and length of stay in our protocol were instituted. METHODS: The authors monitored prospectively clinical outcomes in patients with perforated appendicitis treated according to their clinical practice guidelines over a 43-month period. Patients received a single antibiotic, piperacillin-tazobactam, intravenously for 10 days. They were permitted to go home with a percutaneous intravenous catheter for the final 5 days if medical and social criteria were met. Other practices from our earlier protocol were continued, including immediate operation, placement of Penrose drains, and primary wound closure. RESULTS: Of 150 patients treated on our protocol, major complications included intraabdominal abscess in 5 (3.3%), cecal fistula in 2 (1.3%), phlegmon in 3 (2.0%), wound infection in 4 (2.7%), and no small bowel obstructions requiring operation. None of these complications, nor their aggregate, were significantly more common than those reported in 373 patients treated over 11 years on the authors' prior protocol (chi2, P > .05). CONCLUSIONS: Prospective outcome analysis of our protocol shows that a single broad-spectrum antibiotic (allowing portions of therapy to be delivered less expensively on an outpatient basis) effectively can treat postoperative appendicitis with very few infectious complications. These outcome data provide baseline against which future protocols can be compared. All treatment modifications aimed at decreasing costs must be analyzed to ensure quality of care is not unduly compromised.


Subject(s)
Appendicitis/surgery , Intestinal Perforation/surgery , Adolescent , Anti-Bacterial Agents/administration & dosage , Appendicitis/complications , Appendicitis/economics , Child , Child, Preschool , Drainage , Home Infusion Therapy , Hospital Charges , Humans , Infant , Intestinal Perforation/complications , Intestinal Perforation/economics , Length of Stay , Outcome Assessment, Health Care , Postoperative Complications , Prospective Studies , Rupture, Spontaneous
2.
Contraception ; 41(1): 27-37, 1990 Jan.
Article in English | MEDLINE | ID: mdl-2105871

ABSTRACT

Although review articles have provided much information on the NORPLANT system, information on insertion site complications based on multi-country trials has been limited to infection rates. This paper examines 2,674 NORPLANT acceptors from seven countries who were enrolled and followed for one year. The one-year incidence rates of infection (0.8%), expulsion (0.4%) and local reaction (4.7%) varied widely among countries and clinics within a country. In contrast to previous reports that insertion site complications occur during the first few weeks of use, these data show that a substantial proportion of insertion site infections (34.6%) and implant expulsions (64.3%) were reported after the first two months of use, while 35.7% of local reactions were reported after 4.5 months of use. Of the 16 women with infections who did not have the implants immediately removed, 8 eventually required or requested removal, indicating that the ICCR recommendation for immediate removal in case of infection appears appropriate. An awareness of the frequency of insertion site complications, distribution of the time of onset post-insertion and potential sequelae of complications will aid clinicians in better client counseling and complication management.


PIP: Although review articles have provided much information on the NORPLANT system, information on insertion site complications based on multi- country trials has been limited to infection rates. This paper examines 2,674 NORPLANT acceptors from 7 countries (Bangladesh, Haiti, Nepal, Nigeria, Philippines, Singapore, Sri Lanka) at 19 sites who were enrolled and followed for 1 year. The 1 year incidence rates of infection (0.8%), expulsion (0.4%) and local reaction (4.7%) varied widely among countries and clinics within a country. In contrast to previous reports that insertion site complications occur during the 1st few weeks of use, these data show that a substantial proportion of insertion site infections (34.6%) and implant expulsions (64.3%) were reported after the first 2 months of use, while 35.7% of local reactions were reported after 4.5 months of use. Of the 16 women with infections who did not have the implants immediately removed, 8 eventually required or requested removal, indicating The Population Council's International Committee for Contraception Research (ICCR) recommendation for immediate removal in case of infection appears appropriate. An awareness of the frequency of insertion site complications, distribution of the time on onset post-insertion and potential sequelae of complications will aid clinicians in better client counseling and complication management.


Subject(s)
Contraceptive Agents, Female/adverse effects , Drug Implants/adverse effects , Norgestrel/adverse effects , Vaginitis/complications , Adult , Demography , Female , Follow-Up Studies , Humans , Incidence , Levonorgestrel
3.
Contraception ; 39(5): 541-53, 1989 May.
Article in English | MEDLINE | ID: mdl-2498035

ABSTRACT

Changes in menstrual bleeding patterns are the most frequent reason for discontinuing NORPLANT during the first year of use. Although NORPLANT is used by more women in Asia than in any other region, the changes that occur among these women are not well documented. In pre-introductory clinical trials of NORPLANT in the Philippines and Sri Lanka, 175 women were enrolled with greater than 95% continuing the method after one year. Daily menstrual bleeding calendars were kept by 94% of subjects for nine months and by 66% for one year. In contrast to findings in previous studies which showed that approximately 60% of NORPLANT users had bleeding disruptions in the first year of use, almost all of these women experienced bleeding disruptions. In a one-year study of menstrual pattern changes, increased bleeding was found to occur with the same frequency as reduced bleeding. However, the changes experienced by the Asian women tended to be decreases, rather than increases, in menstrual bleeding.


Subject(s)
Contraceptives, Oral, Combined , Menstruation/drug effects , Norgestrel , Adult , Demography , Female , Follow-Up Studies , Humans , Levonorgestrel , Norgestrel/pharmacology , Philippines , Sri Lanka , Stereoisomerism
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