ABSTRACT
BACKGROUND: Corin is a serine protease that cleaves pro-atrial and pro-B-type natriuretic peptides into biologically active hormones. The relationship between soluble plasma corin levels, plasma natriuretic peptide levels, myocardial structure and performance, and long-term clinical outcomes in the setting of chronic systolic heart failure has not been described. METHODS AND RESULTS: In 126 patients with chronic systolic heart failure (left ventricular ejection fraction Subject(s)
Heart Failure, Systolic/blood
, Heart Failure, Systolic/diagnosis
, Natriuretic Peptide, Brain
, Natriuretic Peptides/blood
, Serine Endopeptidases/blood
, Adult
, Aged
, Biomarkers/blood
, Cardiomegaly/blood
, Chronic Disease
, Cohort Studies
, Female
, Follow-Up Studies
, Humans
, Male
, Middle Aged
, Natriuretic Peptide, Brain/blood
, Prognosis
, Prospective Studies
