Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 37
Filter
Add more filters










Publication year range
1.
Eur J Pharm Sci ; 104: 72-81, 2017 Jun 15.
Article in English | MEDLINE | ID: mdl-28365300

ABSTRACT

Tablet coating is a common unit operation in the pharmaceutical industry. To improve currently established processes, it is important to understand the influence of the process parameters on the coating quality. One of the critical parameters is the tablet velocity. In this work, numerical results are compared to results obtained experimentally. Tablet movement in the drums was simulated using the Discrete Element Method (DEM). The simulation parameters were adapted to fit the simulation to the experimental data. A comparison of the experimental and simulation results showed that the simulation correctly represents the real tablet velocity. A change in the velocity over time and its dependence on the rotation rates and the baffle position in the simulation were similar to the experimental results. In summary, simulations can improve the understanding of tablet coating processes and will thus provide insights into the underlying process mechanics, which cannot be obtained via ordinary experiments.


Subject(s)
Chemistry, Pharmaceutical , Tablets , Drug Compounding
2.
Eur J Pharm Sci ; 93: 74-83, 2016 Oct 10.
Article in English | MEDLINE | ID: mdl-27516146

ABSTRACT

Spray coating of tablets is an important unit operation in the pharmaceutical industry and is mainly used for modified release, enteric protection, better appearance and brand recognition. It can also be used to apply an additional active pharmaceutical ingredient to the tablet core. Scale-up of such a process is an important step in commercialization. However, scale-up is not trivial and frequently, at manufacturing scales the required coating quality cannot be reached. Thus, we propose a method where laboratory experiments are carried out, yet scale-up is done via computational methods, i.e., by extrapolating results to larger scales. In the recent years, the Discrete Element Method (DEM) has widely been used to simulate tablet behavior in a laboratory scale drum coater. Due the increasing computational power and more sophisticated DEM algorithms, it has become possible to simulate millions of particles on regular PCs and model industrial scale tablet coating devices. In this work, simulations were performed on the laboratory, pilot and industrial scales and DEM was used to study how different scale-up rules influence the bed behavior on larger scales. The material parameters of the tablets were measured in the laboratory and a glued sphere approach was applied to model the tablet shape. The results include a vast amount of qualitative and quantitative data at the different scales. In conclusion, the evolution of the inter-tablet coating variation for the different scales and process parameters is presented. The results suggest that keeping the Froude number constant during the scale up process leads to faster processes as the cycle time is shorter and the spray residence time is more uniform when compared to keeping the circumferential velocity constant.


Subject(s)
Tablets , Drug Compounding
3.
Eur J Pharm Biopharm ; 106: 59-69, 2016 Sep.
Article in English | MEDLINE | ID: mdl-27224854

ABSTRACT

The aim of this study was to investigate the influence of qualitatively different powder feeder performances on resulting granule size distributions after twin-screw granulation of a highly drug loaded, hydrophobic mixture and a mannitol powder. It was shown that powder feeder related problems usually cannot be identified by trusting in the values given by the feeder. Therefore, a newly developed model for the evaluation of the performance of powder feeders was introduced and it was tried to connect this model to residence time distributions in twin-screw granulation processes. The influence of feeder performances on resulting granule size distributions varied, depending on the applied screw configuration and the used powder. Regarding the hydrophobic and highly drug loaded formulation, which was granulated at an L/S-ratio of 0.5, a pure conveying screw and a medium kneading configuration, consisting of 60° kneading blocks were negatively influenced by poor feeder settings. For optimal settings more narrow distributions could be obtained. For an extensive kneading configuration good and poor settings resulted in mono-modal granule size distributions but were differing in the overall size. Mannitol, a model substance for a liquid sensitive formulation was granulated at an L/S-ratio of 0.075. It was even more important to maintain optimal feeding as mannitol was highly affected by poor feeder performances. Even an extensive kneading configuration could not level the errors in powder feeder performance, resulting in qualitatively different granule size distributions. The results of this study demonstrate the importance of detailed knowledge about applied feeding systems to gain optimal performance in twin-screw granulation.


Subject(s)
Chemistry, Pharmaceutical , Particle Size , Powders
4.
Eur J Pharm Sci ; 90: 14-24, 2016 Jul 30.
Article in English | MEDLINE | ID: mdl-26709079

ABSTRACT

This work concerns a tablet coating process in an industrial-scale drum coater. We set up a full-scale Design of Simulation Experiment (DoSE) using the Discrete Element Method (DEM) to investigate the influence of various process parameters (the spray rate, the number of nozzles, the rotation rate and the drum load) on the coefficient of inter-tablet coating variation (cv,inter). The coater was filled with up to 290kg of material, which is equivalent to 1,028,369 tablets. To mimic the tablet shape, the glued sphere approach was followed, and each modeled tablet consisted of eight spheres. We simulated the process via the eXtended Particle System (XPS), proving that it is possible to accurately simulate the tablet coating process on the industrial scale. The process time required to reach a uniform tablet coating was extrapolated based on the simulated data and was in good agreement with experimental results. The results are provided at various levels of details, from thorough investigation of the influence that the process parameters have on the cv,inter and the amount of tablets that visit the spray zone during the simulated 90s to the velocity in the spray zone and the spray and bed cycle time. It was found that increasing the number of nozzles and decreasing the spray rate had the highest influence on the cv,inter. Although increasing the drum load and the rotation rate increased the tablet velocity, it did not have a relevant influence on the cv,inter and the process time.


Subject(s)
Drug Industry/instrumentation , Drug Industry/methods , Models, Theoretical , Tablets/chemistry , Technology, Pharmaceutical/instrumentation , Technology, Pharmaceutical/methods , Algorithms , Drug Compounding/instrumentation , Drug Compounding/methods
5.
Int J Pharm ; 496(1): 12-23, 2015 Dec 30.
Article in English | MEDLINE | ID: mdl-26024821

ABSTRACT

As different batches of the same excipients will be intermixed during continuous processes, the traceability of batches is complicated. Simplified formulations may help to reduce problems related to batch intermixing and traceability. Twin-screw granulation with subsequent tableting was used to produce granules and tablets, containing drug, disintegrant and binder (binary and ternary mixtures), only. Drug loads up to 90% were achieved and five different disintegrants were screened for keeping their disintegration suitability after wetting. Granule size distributions were consistently mono-modal and narrow. Granule strength reached higher values, using ternary mixtures. Tablets containing croscarmellose-Na as disintegrant displayed tensile strengths up to 3.1MPa and disintegration times from 400 to 466s, resulting in the most robust disintegrant. Dissolution was overall complete and above 96% within 30 min. Na-starch glycolate offers tensile strengths up to 2.8MPa at disintegration times from 25s to 1031s, providing the broadest application window, as it corresponds in some parts to different definitions of orodispersible tablets. Tablets containing micronized crospovidone are not suitable for immediate release, but showed possibilities to produce highly drug loaded, prolonged release tablets. Tablets and granules from simplified formulations offer great opportunities to improve continuous processes, present performances comparable to more complicated formulations and are able to correspond to requirements of the authorities.


Subject(s)
Chemistry, Pharmaceutical/methods , Drug Compounding/methods , Excipients/chemistry , Ibuprofen/administration & dosage , Carboxymethylcellulose Sodium/chemistry , Delayed-Action Preparations , Drug Liberation , Ibuprofen/chemistry , Particle Size , Povidone/chemistry , Solubility , Starch/analogs & derivatives , Starch/chemistry , Tablets , Tensile Strength
6.
J Pharm Biomed Anal ; 78-79: 57-64, 2013 May 05.
Article in English | MEDLINE | ID: mdl-23454678

ABSTRACT

Incorporation of an active pharmaceutical ingredient (API) into the coating layer of film-coated tablets is a method mainly used to formulate fixed-dose combinations. Uniform and precise spray-coating of an API represents a substantial challenge, which could be overcome by applying Raman spectroscopy as process analytical tool. In pharmaceutical industry, Raman spectroscopy is still mainly used as a bench top laboratory analytical method and usually not implemented in the production process. Concerning the application in the production process, a lot of scientific approaches stop at the level of feasibility studies and do not manage the step to production scale and process applications. The present work puts the scale up of an active coating process into focus, which is a step of highest importance during the pharmaceutical development. Active coating experiments were performed at lab and production scale. Using partial least squares (PLS), a multivariate model was constructed by correlating in-line measured Raman spectral data with the coated amount of API. By transferring this model, being implemented for a lab scale process, to a production scale process, the robustness of this analytical method and thus its applicability as a Process Analytical Technology (PAT) tool for the correct endpoint determination in pharmaceutical manufacturing could be shown. Finally, this method was validated according to the European Medicine Agency (EMA) guideline with respect to the special requirements of the applied in-line model development strategy.


Subject(s)
Chemistry, Pharmaceutical , Calibration , Models, Theoretical , Reproducibility of Results , Spectrum Analysis, Raman , Tablets
7.
Int J Pharm ; 439(1-2): 289-95, 2012 Dec 15.
Article in English | MEDLINE | ID: mdl-22989986

ABSTRACT

Terahertz pulsed imaging (TPI) is a recent and nondestructive technique to quantify coating thickness of pharmaceutical tablet film coatings. In this study, TPI is used for the first time to quantify the progress of an active coating process. The dosage form consisted of a push-pull osmotic system comprising a two-layer tablet core with a functional film coating and a laser drilled hole. On top of this system an active coating was applied. The coating thickness data acquired by TPI and optical microscopy was compared to the quantification of the active pharmaceutical ingredient (API) via HPLC. Good correlation of TPI and HPLC data was shown for coating thicknesses up to 500 µm. Due to the special structure of the dosage form, the TPI detection limit of 38 µm layer thickness was circumvented by analysing the coating thickness of active coating and functional subcoat in one. Therefore it was possible to monitor the active coating process from the very beginning of the process. Optical microscopy was no suitable reference technique for TPI thickness measurements. The active coating showed deformation artefacts during sample preparation, which biased the subsequent thickness measurements.


Subject(s)
Drug Compounding , Tablets/chemistry , Chromatography, High Pressure Liquid , Microscopy , Quality Control , Surface Properties , Terahertz Imaging
8.
Int J Pharm ; 422(1-2): 116-24, 2012 Jan 17.
Article in English | MEDLINE | ID: mdl-22044538

ABSTRACT

Solid lipid extrudates with the model drug praziquantel were produced with chemically diverse lipids and investigated regarding their dissolution behaviour in different media. The lipids used in this study were glyceryl tripalmitate, glyceryl dibehenate, glyceryl monostearate, cetyl palmitate and solid paraffin. Thermoanalytical and dissolution behaviour was investigated directly after extrusion and after 3 and 6 months open storage at 40°C/75% RH. Dissolution studies were conducted in hydrochloric acid (HCl) pH 1.2 with different levels of polysorbate 20 and with a biorelevant medium containing pancreatic lipase, bile salts and phospholipids. Furthermore, the impact of lipid digestion on drug release was studied using in vitro lipolysis. The release of praziquantel from cetyl palmitate and glyceryl monostearate in the biorelevant medium was much faster than in HCl, whereas there was hardly any difference for the other lipids. It was shown that drug release from glyceryl monostearate matrices is driven by both solubilisation and enzymatic degradation of the lipid, whereas dissolution from cetyl palmitate extrudates is dependent only on solubilisation by surfactants in the medium. Moreover, storage influenced the appearance of the extrudate surface and the dissolution rate for all lipids except solid paraffin.


Subject(s)
Anthelmintics/chemistry , Intestinal Secretions/chemistry , Lipids/chemistry , Praziquantel/chemistry , Bile Acids and Salts/chemistry , Chemistry, Pharmaceutical , Drug Storage , Glycerides/chemistry , Humidity , Hydrochloric Acid/chemistry , Hydrogen-Ion Concentration , Kinetics , Lipase/chemistry , Lipolysis , Palmitates/chemistry , Paraffin/chemistry , Phospholipids/chemistry , Polysorbates/chemistry , Solubility , Surface Properties , Technology, Pharmaceutical/methods , Temperature , Time Factors , Triglycerides/chemistry
9.
Int J Pharm ; 412(1-2): 28-36, 2011 Jun 30.
Article in English | MEDLINE | ID: mdl-21497187

ABSTRACT

Flow characteristics and binding properties of Kollicoat IR solutions are promising for an application in suspension layering processes to obtain drug loaded pellets. This study is based on the results of three experimental designs. Within the first one, a suitable binder concentration in suspensions with 35-45% solids was determined. The required binder level was high with 20% in the layer, but led to good and robust process performance with a yield between 92.6% and 97.6%. Since the polymer succeeded to immobilize particles on the starter surface, the second set of experiments observed whether Kollicoat IR was able to layer coarser drug particles with only 8% or 30% of the drug mass below ten microns. Large particle size is a generally known limitation for effective suspension layering. It was shown, that Kollicoat IR was suited to bind 98.5% of the coarsest drug quality on the surface. Additionally these coarse particles acted like a separating agent and kept the pellets from sticking to each other. The third experimental design observed the influence of particle size and viscosity changes. All suspensions had a suitable viscosity with maximum of 120 mPa s. A viscosity change, due to solids in the suspension, did not influence the process performance. The product properties were investigated. The pellets were spherical and size distribution of the pellets was excellent. However the structure was porous, due to the sterical arrangement of the drug particles, although the polymer concentration in the layer was high with a polymer to drug ratio of 1:4.


Subject(s)
Drug Compounding , Drug Implants/chemistry , Excipients/chemistry , Polyvinyls/chemistry , Adhesiveness , Algorithms , Antihypertensive Agents/analysis , Antihypertensive Agents/chemistry , Chemical Phenomena , Hydrochlorothiazide/analysis , Hydrochlorothiazide/chemistry , Microscopy, Electron, Scanning , Particle Size , Porosity , Surface Properties , Suspensions , Temperature , Viscosity , Water/analysis
10.
Drug Dev Ind Pharm ; 35(11): 1325-32, 2009 Nov.
Article in English | MEDLINE | ID: mdl-19832632

ABSTRACT

BACKGROUND: Microcrystalline cellulose (MCC) is the most important pelletization aid in extrusion/spheronization. Because of known disadvantages, the search for substitutes is ongoing. In this context, crospovidone has proven to offer substantial advantages as pelletization aid because of its ability to turn low-soluble active ingredients into fast-dissolving stable pellets. METHOD: Pellets from crospovidone with different amounts of paracetamol, hydrochlorothiazide, and spironolactone as model drugs were prepared by extrusion/spheronization. For comparison, pellets with MCC as extrusion aid were also produced. The pellets of different formulations were evaluated in terms of yield, aspect ratio, mean Feret diameter, 10% interval fraction, tensile strength, disintegration, and drug release profile. RESULTS: Only crospovidone types exhibiting small particle sizes are suitable as pelletization aid. While maintaining the pharmaceutical quality aspects, it was possible to incorporate up to 60% (w/w) active pharmaceutical ingredients (API) into pellets with crospovidone. The most distinguished differences between pellets based on crospovidone and MCC are the disintegration and drug release behavior. The pellets containing binary mixtures of the low-soluble APIs and crospovidone resulted in fast release in contrast to the pellets with MCC as pelletization aid, which exhibited a slow release. CONCLUSION: Crospovidone shows an excellent behavior as pelletization aid and produces fast-releasing pellets even with low-soluble APIs.


Subject(s)
Cellulose/chemistry , Drug Compounding/methods , Drug Implants/chemistry , Excipients/chemistry , Povidone/chemistry , Delayed-Action Preparations/chemistry , Drug Stability , Particle Size , Solubility , Surface Properties , Tensile Strength , Water/chemistry
11.
Pharm Dev Technol ; 14(3): 249-58, 2009.
Article in English | MEDLINE | ID: mdl-19519179

ABSTRACT

kappa-Carrageenan is a biopolymer extracted from red seaweeds which has been in the focus of pharmaceutical development for many years. Most applications make use of the large water binding capacity of kappa-carrageenan. The primary limitation of kappa-carrageenan is the variation in the substance quality. Therefore, the water binding capacity of different kappa-carrageenan products was investigated by dynamic vapor adsorption, freezing and non-freezing bound water and water retention value. The kappa-carrageenans were observed to have a higher water binding capacity than microcrystalline cellulose (MCC) in all three methods. The amount of adsorbed water is similar for all carrageenans. Differences between the carrageenan types (kappa, iota, and lambda) were remarkable for the freezing bound water and centrifugation bound water as well as between the kappa-carrageenans of different suppliers.


Subject(s)
Carrageenan/chemistry , Seaweed/chemistry , Water/chemistry , Freezing , Volatilization
12.
Eur J Pharm Biopharm ; 71(1): 38-46, 2009 Jan.
Article in English | MEDLINE | ID: mdl-18771727

ABSTRACT

Microcrystalline cellulose (MCC) is the golden standard to manufacture spherical particles (pellets) via extrusion-spheronisation since wetted microcrystalline cellulose has the proper rheological properties, cohesiveness and plasticity to yield strong and spherical particles. However, microcrystalline cellulose is not universally applicable due to a number of limitations: prolonged drug release of poorly soluble drugs, chemical incompatibility with specific drugs, drug adsorption onto MCC fibers. Hence, several products have been evaluated to explore their application as extrusion-spheronisation aid, aiming to avoid the disadvantages of MCC and to provide a broad application platform for extrusion-spheronisation: powdered cellulose, starch, chitosan, kappa-carrageenan, pectinic acid, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, polyethylene oxide, cross-linked polyvinylpyrrolidone, glycerol monostearate. To determine the true potential of the proposed alternatives for MCC this review critically discusses the properties of the different materials and the quality of the resulting pellets in relation to the properties required for an ideal extrusion-spheronisation aid.


Subject(s)
Cellulose/chemistry , Excipients/chemistry , Pharmaceutical Preparations/chemistry , Chemistry, Pharmaceutical/methods , Particle Size , Pharmaceutical Preparations/standards , Solubility , Surface Properties , Technology, Pharmaceutical/methods
13.
Eur J Pharm Biopharm ; 71(1): 155-60, 2009 Jan.
Article in English | MEDLINE | ID: mdl-18678245

ABSTRACT

A comparison was made between two twin-screw extruders (APV Baker and Leistritz Micro) used for continuous wet granulation. Both extruders had similar screw configurations, based on the length-to-diameter ratio of the screws, existing out of a conveying zone of 20 D, i.e. 20 times the screw diameter and a granulation zone of 4D. The kneading blocks in the granulation zone were 2.2 and 2.5D for the Leistritz and APV extruders, respectively. An experimental design was used to investigate the influence of process parameters (total input rate and screw speed) and extruder type on granule and tablet quality. Dicalcium phosphate and alpha-lactose monohydrate were used as water-insoluble and water-soluble excipients, respectively. For dicalcium phosphate, the amount of fines (<125 microm), median granule size and granule friability were significantly influenced by extruder type and total input rate. For lactose, the amount of oversized agglomerates and median granule size were significantly affected by extruder type and total input rate. The granule formulations were properly agglomerated on both the extruders, although the extruder type had an important influence on the granule properties, which was more pronounced for dicalcium phosphate. This study shows that a given formulation cannot simply be interchanged between the two extruders without further work on the geometrics of the extruders.


Subject(s)
Calcium Phosphates/chemistry , Excipients/chemistry , Lactose/chemistry , Technology, Pharmaceutical/instrumentation , Chemistry, Pharmaceutical/instrumentation , Particle Size , Solubility , Tablets , Technology, Pharmaceutical/methods
14.
Pharmazie ; 63(7): 514-5, 2008 Jul.
Article in English | MEDLINE | ID: mdl-18717485

ABSTRACT

Film coating fluids commonly contain different pigments. The objective of this work was a study of the distribution of these particles in the coating film. Different pretreatment forms (pigment suspension, pigment paste and untreated pigments) were applied. They were incorporated into a Eudragit L 30 D-55 dispersion. The surface roughness and the mechanical properties of the free films indicated, that the most homogeneous film was obtained with the pigment paste. The homogeneity of the film was investigated by mechanical testing. The protective effect of the coating did not vary with the application of pigments in different forms, but the appearance of the coated tablets underwent a considerable change.


Subject(s)
Coloring Agents/chemistry , Tablets, Enteric-Coated/chemistry , Hardness Tests , Indicators and Reagents , Methacrylates , Polymers , Surface Properties , Suspensions
15.
J Control Release ; 119(3): 253-61, 2007 Jun 22.
Article in English | MEDLINE | ID: mdl-17467098

ABSTRACT

The coating quality of a batch of lab-scale, sustained-release coated tablets was analysed by terahertz pulsed imaging (TPI). Terahertz radiation (2 to 120 cm(-1)) is particularly interesting for coating analysis as it has the capability to penetrate through most pharmaceutical excipients, and hence allows non-destructive coating analysis. Terahertz pulsed spectroscopy (TPS) was employed for the determination of the terahertz refractive indices (RI) on the respective sustained-release excipients used in this study. The whole surface of ten tablets with 10 mg/cm(2) coating was imaged using the fully-automated TPI imaga2000 system. Multidimensional coating thickness or signal intensity maps were reconstructed for the analysis of coating layer thickness, reproducibility, and uniformity. The results from the TPI measurements were validated with optical microscopy imaging and were found to be in good agreement with this destructive analytical technique. The coating thickness around the central band was generally 33% thinner than that on the tablet surfaces. Bimodal coating thickness distribution was detected in some tablets, with thicker coatings around the edges relative to the centre. Aspects of coating defects along with their site, depth and size were identified with virtual terahertz cross-sections. The inter-day precision of the TPI measurement was found to be within 0.5%.


Subject(s)
Image Processing, Computer-Assisted , Imaging, Three-Dimensional , Radio Waves , Spectrum Analysis/methods , Tablets, Enteric-Coated/chemistry , Tablets, Enteric-Coated/standards , Drug Compounding , Microscopy, Confocal , Surface Properties
16.
J Pharm Pharmacol ; 57(6): 689-98, 2005 Jun.
Article in English | MEDLINE | ID: mdl-15969923

ABSTRACT

Different non-ionic cellulose ethers like methyl cellulose (MC), hydroxypropyl cellulose (HPC) and hydroxypropylmethyl cellulose (HPMC) were investigated. The characterization of the cellulose ethers was carried out by thermogravimetry and sorption/desorption isotherms. Differences in the properties of the cellulose ether films were described by time-dependent contact angle measurements. Changes in molecular structure of the raw materials, gels and films caused by water contact were studied using Raman spectroscopy. Differences between the substitution types and changes due to the gel or film formation were observed. An environmental scanning electron microscopy (ESEM) technique was used to distinguish the morphological behaviour of the cellulose ether films in contact with water. Based on in-situ ESEM experiments, the swelling and drying behaviour of the various stages of cellulose ether films (film-hydrated film-dried film) were quantified by using image analysis.


Subject(s)
Cellulose/analogs & derivatives , Excipients/chemistry , Methylcellulose/analogs & derivatives , Water/chemistry , Absorption , Cellulose/chemistry , Gels/chemistry , Hypromellose Derivatives , Methylcellulose/chemistry , Microscopy, Electron, Scanning , Powders/chemistry , Spectrum Analysis, Raman , Thermogravimetry
17.
Int J Pharm ; 242(1-2): 277-80, 2002 Aug 21.
Article in English | MEDLINE | ID: mdl-12176263

ABSTRACT

This article deals with polymer erosion in biodegradable microparticles produced using the phase separation method. Poly(lactic-co-glycolic acid) copolymers with different compositions and molecular weights were employed. The microparticles were stored in phosphate buffer for 6 months. The molecular weight of the polymers was determined by size exclusion chromatography, and the weight loss was monitored gravimetrically. No weight loss was measured in the first weeks, although the molecular weight decreased significantly already from the start. After a certain storage period which was found to be specific for the type of polymer, the weight of the microparticles decreased rapidly. The start of this weight loss occurred when the molecular weight of the polymer in the degrading microparticles reached a threshold of approximately 15,000. This critical molecular weight was found to be identical for all investigated polymers, i.e. it was independent of the initial molecular weight of the polymer and of the lactic-glycolic ratio.


Subject(s)
Drug Compounding/methods , Lactic Acid , Polyglycolic Acid , Polymers , Chromatography, Gel , Drug Storage , Excipients , Microspheres , Molecular Weight , Polylactic Acid-Polyglycolic Acid Copolymer
18.
Fresenius J Anal Chem ; 370(6): 789-91, 2001 Jul.
Article in English | MEDLINE | ID: mdl-11508470

ABSTRACT

First results of experiments on the surface characterization of cellulose derivatives are presented. Different water contents of the surface of microcrystalline cellulose have been investigated by means of Raman spectroscopy, SERS, and environmental scanning electron microscopy (ESEM).

19.
Int J Pharm ; 224(1-2): 141-9, 2001 Aug 14.
Article in English | MEDLINE | ID: mdl-11472823

ABSTRACT

The objective of this study was to investigate some important process parameters on the mixing behavior of a new coater type. The coater used in this study, the Bohle BLC pan coater, differs from other coaters in its high length to diameter ratio. The pan coater can be divided into two zones: drying and spraying zone. The temperature difference between two points in the pan (one in each zone) was used to explore the influence of some process parameters, i.e. the pan speed and the inclination of the rotation axis on the mixing behavior. In addition, the effect of the spray rate on the temperature difference was studied. The results of the current study demonstrated the possibility to characterize the mixing behavior in a pan coater by a simple temperature measurement. The temperature difference method resulted in a model, which was comparable to the model from a conventional mixture experiment. It was shown that the pan speed and the spray rate influenced the temperature difference and, consequently, the mixing efficiency. However, the inclination of the rotation axis did not show an important effect.


Subject(s)
Drug Compounding/instrumentation , Drug Compounding/methods , Tablets, Enteric-Coated/chemical synthesis , Temperature
20.
Chem Pharm Bull (Tokyo) ; 49(2): 140-6, 2001 Feb.
Article in English | MEDLINE | ID: mdl-11217098

ABSTRACT

Melt pelletization experiments with sodium valproate as a hygroscopic drug were performed in a laboratory scale high shear mixer. In the current part, the effect of altering the binder liquid properties (using different binders, varying the temperature, or adding highly dispersed silicon dioxide to the molten binder) on the pellet size, size distribution and the growth rate was studied. Three meltable binders, namely glycerol monostearate (GMS), hydrated castor oil (HCO), and polyethylene glycol (PEG), were included in the study. Two series of experiments with GMS or HCO showed a higher granule growth rate with decreasing binder viscosity. Also, increases in the granule growth rate were observed for all meltable binders tested, when the binder amount and the impeller speed were increased. Factorial designs with all three binders were performed under the same conditions. In these experiments, no correlation existed between the granule growth rate and the viscosity of the different binders. The different granule growth rate, however, was mainly attributed to the different solubility of sodium valproate in the binder liquid used. Higher solubility increased the volume of the binder liquid and, accordingly, the granule growth rate. Taking the amount of dissolved drug into account, the granule growth rates of GMS and PEG were comparable. However, HCO displayed a lower granule growth rate, which might be related to its low adhesion tension. During melt pelletization in a high shear mixer the solubility of the drug in the molten binder strongly influences the pelletization process.


Subject(s)
Valproic Acid/chemistry , Silicon Dioxide/chemistry , Viscosity , Water/chemistry
SELECTION OF CITATIONS
SEARCH DETAIL
...