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World J Gastroenterol ; 28(40): 5827-5844, 2022 Oct 28.
Article in English | MEDLINE | ID: mdl-36353206

ABSTRACT

Acinar cell carcinoma (ACC) is a rare pancreatic malignancy with distinctive clinical, molecular, and morphological features. The long-term survival of ACC patients is substantially superior to that of pancreatic adenocarcinoma patients. As there are no significant patient series about ACCs, our understanding of this illness is mainly based on case reports and limited patient series. Surgical resection is the treatment of choice for patients with the disease restricted to one organ; however, with recent breakthroughs in precision medicine, medicines targeting the one-of-a-kind molecular profile of ACC are on the horizon. There are no standard treatment protocols available for people in which a total surgical resection to cure the condition is not possible. As a result of shared genetic alterations, ACCs are chemosensitive to agents with activity against pancreatic adenocarcinomas and colorectal carcinomas. The role of neoadjuvant or adjuvant chemoradiotherapy has not been established. This article aims to do a comprehensive literature study and present the most recent information on acinar cell cancer.


Subject(s)
Carcinoma, Acinar Cell , Pancreatic Neoplasms , Humans , Carcinoma, Acinar Cell/genetics , Carcinoma, Acinar Cell/therapy , Carcinoma, Acinar Cell/pathology , Pancreatic Neoplasms/genetics , Pancreatic Neoplasms/therapy , Pancreatic Neoplasms/pathology , Immunohistochemistry , Mutation , Pancreatic Neoplasms
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