1.
Biochim Biophys Acta
; 950(3): 450-4, 1988 Sep 07.
Article
in English
| MEDLINE
| ID: mdl-3167063
ABSTRACT
During acute inflammation or after administration of monocytic products, an enhanced transcription of the fibrinogen polypeptide genes and a reduced transcription of the albumin gene were observed. The changes in the fibrinogen polypeptide transcriptional rate were found to precede the change in albumin gene transcription. These findings indicate that the altered synthesis of fibrinogen and albumin during inflammation are regulated at the transcriptional level and are most probably mediated by monocytic products (including interleukin-1).