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Nefrología (Madrid) ; 40(2): 197-201, mar.-abr. 2020. tab, graf
Article in Spanish | IBECS | ID: ibc-199108

ABSTRACT

La peritonitis recidivante en pacientes en diálisis peritoneal es una de las complicaciones que ponen en riesgo la continuidad de la técnica. Se asocia a menudo con la formación de biofilm en la luz del catéter. Hasta la fecha, su retirada sigue siendo la única actitud recomendada. Debido a sus propiedades antimicrobianas y antifúngicas, se ha utilizado taurolidina para el sellado de catéteres de vías centrales y de hemodiálisis. A pesar de los buenos resultados obtenidos, no existen datos sobre su utilidad en diálisis peritoneal. Se presentan 5 casos de peritonitis recidivante en los que se utilizó sellado con taurolidina (TauroLock(TM) HEP 500) tras cumplir tratamiento antibiótico. Se realizó un seguimiento medio de 13,4 meses para la detección de recidivas. En 4 pacientes con infecciones provocadas por Staphylococcus epidermidis se consiguió la erradicación. En el caso restante, causado por Staphylococcus aureus, el sellado con taurolidina fue inefectivo y precisó la retirada del catéter


Relapsing peritonitis in peritoneal dialysis patients is one of the complications that jeopardizes the continuity of the technique. It is often associated with the formation of biofilm in the lumen of the catheter. To date, its removal remains the only recommended attitude. Due to its antimicrobial and antifungal properties, taurolidine has been previously used for the sealing of central line catheters and hemodialysis. Despite the good results obtained, there is no evidence available regarding its utility in peritoneal dialysis. This case report describes the use of taurolidine (TauroLock(TM) HEP500) in 5 patients with relapsing peritonitis after antibiotic treatment completion. Mean follow-up for the detection of recurrences was 13.4 months. In 4 patients with infections caused by Staphylococcus epidermidis, eradication was achieved. In the remaining case, caused by Staphylococcus aureus, the taurolidine seal was ineffective and the removal of the catheter was required


Subject(s)
Humans , Male , Middle Aged , Aged , Aged, 80 and over , Anti-Infective Agents, Local/therapeutic use , Catheter-Related Infections/drug therapy , Peritoneal Dialysis/adverse effects , Peritonitis/drug therapy , Taurine/analogs & derivatives , Anti-Bacterial Agents/therapeutic use , Catheter-Related Infections/microbiology , Peritoneal Dialysis/instrumentation , Peritonitis/microbiology , Recurrence , Staphylococcal Infections/drug therapy , Staphylococcus aureus , Staphylococcus epidermidis , Taurine/therapeutic use , Vancomycin/therapeutic use
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