[Role of hormonal factors in the regulation of bone tissue metabolism in children with cerebral palsy]. / Rol' gormonal'nykh faktorov v reguliatsii obmena kostnoi tkani u detei s tserebral'nymi paralichami.

In the article are presented the results of examination of 98 patients (aged 6-16 years) with infantile cerebral paralysis. There were used X-ray and radioimmune investigations of bone age, enchondral ossification, state of foot bone structure and blood concentration of "osteotropic" hormones. Bone age corresponded mainly to the passport one; ossification rate overtake and deceleration have been revealed in a third of the examined children and concentric atrophy in 30% patients. Structural disturbances of osseous tissue as the different forms of osteoporosis have been detected in 89.5% cases. There have been stated direct correlation between the frequency of disturbances and the form of infantile cerebral paralysis. There have been noted reliable increase of hydrocortisone level and significant decrease of somatotropic hormone concentration (by 70% and 3.5-3.7 times as compared with the control) and sexual differences in concentrations of osteotropic hormones. The results are discussed from the point of view of neurohumoral relation disturbances and the presence of vegetative dystonia syndrome with predominance of sympathetic-adrenal system activity.

[Correction of autonomic hyperreactivity in surgery of children with spastic cerebral palsy]. / Korrektsiia neirovegetativnoi giperreaktivnosti pri khirurgicheskikh operatsiiakh u detei s tserebral'nymi spasticheskimi paralichami.

Cardiovascular system parameters were used to investigate autonomous nervous system tone in 97 children with cerebral spastic paralysis during and after surgical treatment of contractures and vascular deformities in the lower extremities. The investigations have shown that additional protection of the autonomous nervous system with gangliolytics promotes to a decrease and stabilization of the autonomous nervous system tone. The necessity of an objective control over the autonomous nervous system tone in children with cerebral spastic paralysis and differentiated tactics of hyperreactivity correction with gangliolytics are discussed.

[The use of phenobarbital and carbamazepine (finlepsin) in children with epilepsy and cerebral spastic palsy with epileptic syndrome]. / Osobennosti primeneniia fenobarbitala i karbamazepina (finlepsina) u detei bol'nykh épilepsiei i tserebral'nymi spasticheskimi paralichami s épilepticheskim sindromom.

Based on examining 20 patients with infantile cerebral paralyses (ICP) and 18 epileptic patients aged 6 to 14 years it has been demonstrated that the effective doses of carbamazepine do not differ (14-27 mg/kg/day) in both the groups, whereas the effective doses of phenobarbital are higher (5.3 mg/kg/day) in ICP patients than in those suffering from epilepsy (3.65 mg/kg/day; P less than 0.05). In this case the blood concentration of both carbamazepine and phenobarbital was lower in ICP patients (5.1 and 23.1 mg/l, respectively, than in epileptic patients (8.2 and 28.8 mg/l). The drug levels in the blood serum were measured by high-effective liquid chromatography. It was assumed that the efficacy of the lower drug concentrations in ICP patients was related to greater permeability of the blood-brain barrier or with higher sensitivity of "epileptized" neurons in them as compared to epileptic patients. The comparison of the doses and blood concentrations may point to more intense biotransformation of the antiepileptic agents in the body of ICP patients than in patients suffering from epilepsy.

[Electrophysiological evaluation of the age-related characteristics of the central nervous system in children with spastic cerebral palsy]. / Elektrofiziologicheskaia otsenka vozrastnykh osobennostei tsentral'noi nervnoi sistemy u detei s tserebral'nym spasticheskim paralichom.

As a result of the conducted studies, the authors were able to demonstrate that in children from 4-9 years with cerebral spastic paralysis the potentiated tonic reactions are preserved (the reflex of distention from the gastrocnemius muscle, cervico-tonical reflex to the extremities and reaction of support). The frequency and regularity of alpha-rhythm on the EEG of these children differ significantly from similar ones of normal children of the same age. As the children grow older, the frequency of exaltated tonic reactions decrease and at the same time the frequency and regularity of alpha-rhythms increases, however the differences compared to age norms are preserved. The authors are of the opinion that in older children with infantile cerebral paralysis, despite the retardation of the morpho-functional development of the higher areas of the brain, the degree of cortical maturity is sufficient to inhibit an increased activity of the stem centres regulating the muscular tone.