[The efficacy of fiber bronchoscopy under outpatient polyclinic conditions]. / Effektivnost' nronkhofibroskopii v ambulatorno-poliklinicheskikh usloviiakh.

Basing on the experience of conducting 795 bronchofibroscopies under conditions of polyclinic authors discuss organized and methodological aspects ensuring maximal study safety permitting to avoid serious, danger for life complications. Pathologic changes of tracheobronchial tree were exposed in 64.6% cases, 46.5% of them--inflammations, 4.9% of cases--bronchus cancer. Morphologic cancer verification when conducting biopsy was 84.6%, when making cytologic examination of bronchial liquid-17.9%.

[The morphostructural disorders of the gastric mucosa in peptic ulcer]. / Morfostrukturnye narusheniia slizistoi obolochki zheludka pri iazvennoi bolezni.

200 patients with ulcerative disease of the stomach have been examined. It is indicated that 87% of patients showed chronic gastritis, more often with mucosal atrophy. 7.9% of patients revealed isolated dysplasia of various expression degree, in 38.2%--isolated regenerative disturbances, and in 24.3%--associations of dysplasia with regeneration defects. 9.5% of patients showed malignant ulcer (with atrophic and atrophic hyperplastic gastritis--in 13.8% of cases, and with isolated dysplasia--in 41.7%, with isolated regenerative disturbances--in 5.2%, with association of dysplasia and regenerative defects--in 29.7%). To determine resection value one should account extensions morpho-structural alterations in gastric mucosal membrane.

[Status of humoral and cellular immunity in patients with a frequently recurring form of stomach ulcer in the presence of Campylobacter pylori]. / Sostoianie gumoral'nogo i kletochnogo immuniteta u bol'nykh s chasto retsidiviruiushchei formoi iazvennoi bolezni zheludka pri nalichii Campylobacter pylori.

The findings at examination of 42 patients with gastric ulcer exhibiting frequent relapses were comparatively assessed in relation to humoral and cellular immunity, presence of mucous microflora and Campylobacter pyloridis at the ulcer site. It is shown that in the presence of Campylobacter pyloridis specific differences in the immune response were not recorded. The same results were true for mucous microflora.

[The treatment of patients with long-term nonhealing duodenal ulcers combined with chronic gastric erosions in the presence of Helicobacter pylori]. / Lechenie bol'nykh s dlitel'no ne zazhivaiushchimi iazvami dvenadtsatiperstnoi kishki v sochetanii s khronicheskimi éroziiami zheludka pri nalichii Helicobacter pylori.

Data are reported of the efficacy of different drugs in the treatment 66 patients with prolonged nonhealing duodenal ulcers in association with chronic erosions in the presence of Helicobacter pylori. It was found that a concentrate of granulocytes and de-nol proved most efficient while trichopol and furazolidone were of minor efficacy.

[Role of Campylobacter pylori and mucous microflora in the pathogenesis of long-non-healing stomach ulcers]. / Rol' Campylobacter pylori i mukoznoi mikroflory v patogeneze dlitel'no nezazhivaiushchikh iazv zheludka.

Altogether 89 patients with long non-healing gastric ulcers were examined for Campylobacter pylori (CP) and mucous microflora. It is shown that in patients with long non-healing gastric ulcers, CP was only demonstrable in 19.8% of cases whereas pathological microflora (Candida and microbial associations) in 72.3% of cases. In patients with CP, the administration of de-nol, metronidazole and ampicillin were not sufficiently effective.

[The humoral and cellular immunity indices of patients with long-term nonhealing stomach ulcers with the presence of Campylobacter pylori]. / Pokazateli gumoral'nogo i kletochnogo immuniteta u bol'nykh s dlitel'no nezazhivaiushchimi iazvami zheludka pri nalichii Campylobacter pylori.

The authors relate the data on humoral and cellular immunity in patients with long nonhealing gastric ulcers. It has been shown that if these patients have Campylobacter pylori, there are no specific differences in the response of the immune system. During cicatrization, positive changes can be seen, namely an increase of T helper and decrease of suppressor activity of T lymphocytes together with a decline of the content of IgA and IgG.

[The role of the hypophyseal-gonadal system in forming long-term nonhealing duodenal ulcers]. / Rol' gipofizarno-gonadnoi sistemy v formirovanii dlitel'no nezazhivaiushchikh iazv dvenadtsatiperstnoi kishki.

The authors provide the data on the hormonal spectrum (STH, gastrin, sex hormones) in patients with long unhealing duodenal ulcers. It is shown that changes in the concentrations and ratios of the concentrations of hypophyseal-gonadal hormones may serve as a defensive adaptation reaction of the body and may be due to activation of the adaptation systems that mediate the neurohumoral mechanisms of regulation. Such changes are more remarkable in patients with common peptic ulcer. Apparently, in patients with long unhealing ulcers, these mechanisms tend toward depletion, as a result of which the other mechanisms start prevailing (microcirculatory disorders, immunologic abnormalities, pathological microflora).

[The characteristics of the clinical course of long-term nonhealing duodenal ulcers combined with chronic gastric erosion and the treatment of patients with the given pathology]. / Osobennosti klinicheskogo techeniia dlitel'no nezazhivaiushchikh iazv dvenadtsatiperstnoi kishki v sochetanii s khronicheskimi éroziiami zheludka i lecheniia bol'nykh s dannoi patologiei.

The authors provide data on the follow-up and treatment of 76 patients with slow in healing ulcers and chronic erosions. In patients with associated pathology, the clinical course of the disease is marked by a steady painful syndrome that occurs 1 to 1.5 h after meal. In the presence of Campylobacter pyloridis in these patients, the treatment schedule is to include de-nol and the concentrate of granulocytes. The use of local administration of the concentrate of granulocytes combined with hyperbaric oxygenation turned out the most effective in multimodality treatment of such patients.

[Protein kinase activity and cAMP level in gastric mucosa in non-neoplastic diseases]. / Aktivnost' proteinkinaz i soderzhanie cAMP v slizistoi obolochke zheludka pri neopukholevykh zabolevaniiakh.

Activity of cAMP-dependent and -independent protein kinases as well as content of cAMP were studied in biopsy preparations of gastric mucosal membranes obtained from patients with superficial gastritis, erosion, ulcer, adenomatous polyps and ulcer after treatment with laser irradiation. All the patterns studied were similar in preparations of adenomatous polyps and normal mucosal membrane. Activity of cAMP-independent protein kinases was increased under conditions of erosion, ulcer, gastroduodenal reflux and, especially, in ulcer tissue treated with laser. However, the ratio between cAMP-independent and -dependent phosphorylation was increased only in 50% of ulcerous diseases and in gastroduodenal reflux. The equilibrium of cAMP-dependent and -independent phosphorylation was not altered in the other impairments studied even though benign proliferation was stimulated using laser irradiation.

[Expediency of preventive examination of the upper parts of the gastrointestinal tract]. / O tselesoobraznosti profilakticheskogo obsledovaniia verkhnikh otdelov zheludochno-kishechnogo trakta.

Gastroscopic examination of 528 practically healthy people showed that every fifth person aged from 41 to 60 and every third one older than 60 had a focal pathology of the stomach such as cancer, polyps, errosion, ulcer etc. Prophylactic gastroscopy is shown to be necessary in people aged over 45.