ABSTRACT
Fifty-nine patients exhibiting an exacerbation of multiple sclerosis were examined for efficacy of enterosorption with the fibrous coal sorbent vaulen. The solvent powder was administered 3 times a day in a dose of 50-60 mg/kg for 20 days between meals. The relief of neurological symptoms started on treatment days 3-4 with subsequent attenuation within the course of treatment. This agreed with discontinuation of liquor hypertension and recovery of normal immunological spectra of serum parameters. The method of enterosorption is simple, safe and readily arrests the disease exacerbation.
Subject(s)
Charcoal/therapeutic use , Enterosorption/methods , Multiple Sclerosis/therapy , Adult , Charcoal/administration & dosage , Drug Administration Schedule , Female , Humans , Male , Middle Aged , Remission InductionABSTRACT
Analysis is made of the efficacy of the treatment of CSF hypertension in 40 patients in the phase of exacerbation of multiple sclerosis. Use was made of sorption detoxication methods: hemoperfusion (the author's certificate No.1466754) and enterosorption (the priority certificate No.4465054/14 (115542) dated July 22, 1988). SKH-IK and SKH-2K sorbents were employed as hemoperfusion, using the venovenous scheme of perfusion, the volumetric rate of the blood flow being 100-120 ml/min during 2-3 hours. Altogether 2-3 sessions were carried out, with an interval of 5 to 7 days. For enterosorption, use was made of a crumbled up filamentous carbonic sorbent in a dose of 50-60 mg per kg bw 3 times a day for 20 days in 2 hourly intervals between food intake. Regression of the neurological symptoms began 2-3 hours after the first session of hemoperfusion and 5-6 days after the beginning of the intake of the filamentous carbonic sorbent, increasing throughout the whole treatment course. That coincided with the disappearance of CSF hypertension and normalization of the immunological spectrum of the blood serum. Sorption detoxication brought about no complications and is a method of choice in the treatment of CSF hypertension in patients in the phase of multiple sclerosis exacerbation.
Subject(s)
Enterosorption/methods , Hemoperfusion/methods , Intracranial Pressure/physiology , Multiple Sclerosis/cerebrospinal fluid , Pseudotumor Cerebri/therapy , Acute Disease , Adult , Charcoal/therapeutic use , Electroencephalography , Female , Humans , Male , Multiple Sclerosis/complications , Pseudotumor Cerebri/diagnosis , Pseudotumor Cerebri/etiologyABSTRACT
Seventeen patients with generalized myasthenia were treated by the enterosorbent vaulen for 20 days. Of these, 12 patients manifested an appreciable improvement of the well-being shown up by the enhancement of the power of oculomotor, mimic, bulbar, respiratory and body musculature. As a result of the treatment, the dose of anticholinesterase drugs was reduced 2-fold in 12 patients. The intake of these drugs could be fully discontinued in 3 patients. The clinically detectable improvement correlated with an increase of the amplitude of M-response and a reduction of the amplitude decrement during stimulation at a frequency of 3 imp/s. No changes in the electrolyte composition of the blood and protein fractions or other side effects of the drug were discovered. The data obtained served the basis for recommending enterosorption as one of the methods in a complex of treatment measures for patients suffering from myasthenia.
