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Bioorg Med Chem Lett
; 11(19): 2569-72, 2001 Oct 08.
Article
in English
| MEDLINE
| ID: mdl-11551751
ABSTRACT
Derivatives of 1-[2-(4-carboxyphenoxy)ethyl]-3-dodecanoylindole-2-carboxylic acid (4) with modified substituents at the indole-1-position were synthesized and evaluated for their ability to inhibit the arachidonic acid release in human platelets mediated by the cytosolic phospholipase A(2). One of the most active compounds obtained was 26 with an IC(50) of 0.44 microM.
