ABSTRACT
In 60 healthy non-obese persons we determined fasting plasma insulin concentrations. Afterwards we performed test with oral load with 75 g glucose. We determined plasma concentration of insulin one hour and two hours after this load; we found that 14 of 60 subjects had hyperinsulinemia with normal glucose tolerance. In the group of persons with hyperinsulinaemia we have shown the increase of fasting plasma triglyceride levels and elevated diastolic blood pressure. We suggested that healthy persons with hyperinsulinemia and normal glucose tolerance have an increase risk for cardiovascular diseases.
Subject(s)
Cholesterol/blood , Glucose Tolerance Test/methods , Hyperinsulinism/blood , Insulin/blood , Triglycerides/blood , Cardiovascular Diseases/blood , Female , Humans , Male , Risk FactorsABSTRACT
In 30 patients suffering from systemic allergic reactions following Hymenoptera insect bites risk factors have been evaluated. Life-style, place of living, patients' age, sex and the presence of atopy have been considered. Moreover, the clinical course and value of the intracutaneous quantitative tests have been analysed and their value in both the diagnosis and prognosis of the said reactions have been assessed. Significant correlation between the results of quantitative diagnostic tests and severity of the hypersensitivity to insect poison has been found. A phenomena of the spontaneous diminished skin reactions has been noted. It has been found that only an individual analysis of the natural history might be a base for the choice of appropriate therapy.
Subject(s)
Hymenoptera , Hypersensitivity, Immediate/diagnosis , Insect Bites and Stings/immunology , Adult , Animals , Female , Humans , Hypersensitivity, Immediate/immunology , Hypersensitivity, Immediate/therapy , Insect Bites and Stings/therapy , Male , Middle Aged , Prognosis , Risk Factors , Skin TestsABSTRACT
The aim of presented study were to assess the usefulness of rhinomanometry in monitoring course of disease and effectivity of treatment in seasonal allergic rhinitis (SAR) through answering the question whether and eventually which relationship exists between patient's general feeling and results of rhinomanometric measurements of nasal patency (NP). The study involved 114 subjects with SAR divided into 3 groups dependent on phase of disease and severity of complaints and 30 healthy volunteers. For results see table I. Nasal flow and resistance measured at differential pressure 75 Pa in groups I, III and IV did not differ significantly. In group II nasal flow values were lower (alpha < 0.001) and resistance values higher (alpha < 0.001) as compared with remaining groups. Thus, the beginning of symptoms is related to lowering of NP as compared with symptom-free phase of SAR. In the symptom-free period NP do not differ from healthy population. The results of rhinomanometric measurements of NP are useful in monitoring of course of SAR in assessment of effectivity of treatment.
Subject(s)
Manometry , Nasal Obstruction/diagnosis , Rhinitis, Allergic, Seasonal/physiopathology , Adult , Airway Obstruction/physiopathology , Airway Resistance/physiology , Female , Humans , MaleABSTRACT
Eleven kidney transplant recipients with the oral or/and throat candidiasis which occurred during the first 3 months after transplantation were studied. Fluconazole was administered orally in the dose of 50 mg each 24, 48, 72 h, according to creatinine clearance. No clinical symptoms of candidiasis on the third day of the treatment were observed. In all patients, negative mucosal cultures were noted at the 8th day after first fluconazole dose. During fluconazole was with in normal range. Furthermore, no changes in serum bilirubin alanine transaminase, lactate dehydrogenase and alkaline phosphatase activities were observed. Serum creatinine decreased during this follow-up. In the 30th day after fluconazole administration cessation the mycological evidence of Candida p. reinfection were noted in 25% of patients. Fluconazole is highly efficient and safe agent to manage the oral and throat candidiasis in renal transplant recipients.
Subject(s)
Candidiasis, Oral/drug therapy , Fluconazole/therapeutic use , Kidney Transplantation , Pharyngeal Diseases/drug therapy , Adult , Candidiasis, Oral/etiology , Female , Humans , Immunosuppression Therapy/adverse effects , Male , Middle Aged , Pharyngeal Diseases/etiologyABSTRACT
In two rat models of portal hypertension obtained by common bile duct obstruction or by partial portal vein ligation the hypothalamic level of leu-enkephalin was increased but striatal and plasma level of leu-enkephalin was unchanged. These results may be of importance for understanding some disturbance related to hepatic encephalopathy.
Subject(s)
Corpus Striatum/metabolism , Enkephalin, Leucine/metabolism , Hypertension, Portal/metabolism , Hypothalamus/metabolism , Animals , Bilirubin/blood , Disease Models, Animal , Enkephalin, Leucine/analysis , Liver/pathology , Male , Organ Size , Radioimmunoassay , Rats , Rats, Wistar , Spleen/pathologyABSTRACT
Our studies showed that the nifedipine in daily doses of 30 mg/kg given to rabbits treated with a diet containing 1% cholesterol for 6 months, decreased cholesterol content in aorta homogenates, urine excretion of desmosines and prolonged partial thromboplastin time, while it did not alter serum lipids. These results may have some value for understanding of the antiatherogenic mechanism of nifedipine.
