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Bioorg Med Chem Lett
; 19(20): 5887-92, 2009 Oct 15.
Article
in English
| MEDLINE
| ID: mdl-19762238
ABSTRACT
A series of phenylaminopyrimidines has been identified as inhibitors of Janus kinases (JAKs). Development of this initial series led to the potent JAK2/JAK1 inhibitor CYT387 (N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-benzamide). Details of synthesis and SAR studies of these compounds are reported.
