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1.
Acta Radiol ; 35(6): 614-8, 1994 Nov.
Article in English | MEDLINE | ID: mdl-7946687

ABSTRACT

Iodixanol (Visipaque) 320 mg I/ml, a non-ionic, dimeric, isotonic contrast medium, was compared to ioxaglate (Hexabrix) 320 mg I/ml in cardioangiography. One hundred and two patients with normal renal function were included in the study. The objectives were to evaluate safety, tolerability, radiographic efficacy and effects on renal function. Adverse events, discomfort, vital signs, clinical chemistry parameters, diagnostic information and radiographic density were recorded. Both contrast media had minor effects on the renal function parameters monitored. The patients who received iodixanol experienced fewer adverse events, significantly less discomfort and had a lower increase in heart rate than did the patients in the ioxaglate group. The radiographic efficacy was good in both groups. Iodixanol 320 mg I/ml is safe and effective for use in cardioangiography.


Subject(s)
Contrast Media , Coronary Disease/diagnostic imaging , Ioxaglic Acid , Triiodobenzoic Acids , Adult , Aged , Angiocardiography , Contrast Media/adverse effects , Double-Blind Method , Female , Humans , Ioxaglic Acid/adverse effects , Male , Middle Aged , Triiodobenzoic Acids/adverse effects
2.
Clin Radiol ; 48(4): 268-72, 1993 Oct.
Article in English | MEDLINE | ID: mdl-8243006

ABSTRACT

A new non-ionic, dimeric contrast medium iodixanol (Nycomed AS, Norway) has a very low osmolality and is isotonic with blood. It has been compared with ioxaglate (Hexabrix, Laboratoire Guerbet, France) in a double-blind, randomized, parallel trial. The aims of the trial were to evaluate and compare the safety (vital signs, adverse events, discomfort and clinical-chemical parameters in blood and urine) and radiographic efficacy (diagnostic information and radiographic density) of iodixanol 320 mg I/ml vs ioxaglate (Hexabrix 320 mg I/ml) in coronary angiography and left ventriculography. Seventy-six patients referred for cardioangiography, two patients were withdrawn, 36 receiving iodixanol and 38 ioxaglate were included in the trial. Six patients (16%) in the iodixanol group and 16 (42%) patients in the ioxaglate group reported adverse events (P = 0.02). One serious adverse event occurred in the iodixanol group where a patient experienced transient cortical blindness and transitory global amnesia, but the patient recovered completely the day after the examination. Twenty-six patients reported injection-associated sensation of warmth in the iodixanol group versus 34 in the ioxaglate group (P = 0.06). Following contrast injection there were no differences between the groups regarding vital signs (ECG, heart rate, left ventricular pressures). Both contrast media were well tolerated by the kidneys, and on average only minor effects on clinical-chemical parameters in blood and urine were observed in the two groups. The radiographic efficacy was good in both groups.


Subject(s)
Contrast Media , Coronary Angiography , Heart/diagnostic imaging , Ioxaglic Acid , Triiodobenzoic Acids , Adolescent , Adult , Aged , Blindness/chemically induced , Body Temperature/drug effects , Double-Blind Method , Female , Glomerular Filtration Rate/drug effects , Heart Ventricles/diagnostic imaging , Humans , Ioxaglic Acid/adverse effects , Male , Middle Aged , Triiodobenzoic Acids/adverse effects
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