Solid dispersion of ketoprofen in pellets.

The formulation of ternary solid dispersions of ketoprofen with Macrogol and kollagen hydrolizate derivative as carriers was elaborated on the basis of the results of the experiments in which different methods of solid dispersion preparation (melting, solvent method, different cooling), different concentrations of drug/carriers and molecular weight of Macrogol were tested. The best solid dispersion consisted of: ketoprofen-Macrogol 6000-KLH(T) (1+8. 9+0.1) was chosen to formulate the pellets on the basis of the pharmaceutical availability of ketoprofen from solid dispersion and the physical chemical studies: thermomicroscopic, DSC and X-ray diffraction. The pellets were prepared by the extrusion and spheronization method. The mechanical properties of the pellets as well as ketoprofen released from pellets containing solid dispersion, in comparison with physical mixtures and the drug alone, were evaluated. The increase in the amount of released ketoprofen from solid dispersion pellets was 3.8-times greater than from the pellets containing the drug alone. The stability of solid dispersion pellets was satisfactory.

[In vitro assessment of metronidazole adapted to the treatment of periodontopathies]. / Ocena in vitro metronidazolu przystosowanego do leczenia parodontopatii.

Chemical and biological assessment was done in vitro of a form of metronidazole for application into deep pouches in periodontal diseases. The obtained plates with metronidazole contained 1.4 mg (37%) of pure substance. Comparing the effect of metronidazole release in time against a control plate it was noted that the drug was released during 3 days in similar proportions from the chemical and biological samples.

In vitro study of (2S, 2'S) N,N'-dimethyl-N, N'-bis [1(3', 4', 5'-trimethoxybenzoyloxy) butyl-2] ethylenediamine salts and their bioavailability.

The aim of this study was to improve the oral dosage form of the title compound. The study include base, dihydrochloride and dimaleate. In vitro study was carried out on rat intestine, in vivo on rats and rabbits. The low absorption of the M-71 salts has been shown in both in vitro and in vivo studies. To increase bioavailability in men the tablets or enteric coated tablets should be made according to the results of clinical trials.