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Article in English | MEDLINE | ID: mdl-11977363

ABSTRACT

The influence of cisplatinum and goserelinum on the magnesium and calcium concentration in rat serum has been studied. The cisplatinum induces decrease in serum magnesium concentration (to 70%), and calcium concentration (to 63%). Goserelinum activity was similar to cisplatinum activity. The magnesium concentration decreased to 60%, and calcium to 44%. In condition of cisplatinum and goserelinum activity the hypomagnesemia and hypocalcemia were noted.


Subject(s)
Calcium/blood , Cisplatin/pharmacology , Goserelin/pharmacology , Magnesium/blood , Animals , Antineoplastic Agents/pharmacology , Hypocalcemia/chemically induced , Rats , Rats, Wistar
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