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1.
J Endourol ; 26(8): 980-2, 2012 Aug.
Article in English | MEDLINE | ID: mdl-22416671

ABSTRACT

The midurethral sling has emerged as an effective, minimally invasive treatment for patients with stress urinary incontinence. Bladder penetration is a known complication that, if unrecognized, may result in retained intravesical mesh. This rare complication can cause patient discomfort as well as become a nidus for infection and bladder calculi. Because of the technique of sling passage, the site of retained sling material is often along the anterior bladder wall, making evaluation and treatment via traditional retrograde cystoscopy prohibitively difficult. We describe a novel and minimally invasive method to remove the sling material using antegrade access into the bladder in conjunction with holmium laser vaporization. In our series of six patients in whom retrograde cystoscopic treatment had failed, all were successfully treated with antegrade cystoscopy and reported improved urinary symptoms. This new technique provides a simple, minimally invasive, and effective method for removal of exposed sling mesh.


Subject(s)
Cystoscopy/methods , Device Removal , Suburethral Slings , Surgical Mesh , Urinary Bladder/surgery , Adult , Aged , Cystoscopy/instrumentation , Female , Humans , Middle Aged
2.
Curr Urol Rep ; 10(5): 390-5, 2009 Sep.
Article in English | MEDLINE | ID: mdl-19709487

ABSTRACT

Transobturator tape midurethral sling is the latest method for treatment of female urinary incont-inence. The authors describe their technique via an outside-in approach under local anesthetic to ensure proper tightening of the sling. Placement through the obturator foramen is straightforward and virtually eliminates risk of serious intraoperative major organ or vessel injury. Although outcome data lack the long-term follow-up of colposuspension and tension-free vaginal tape, similar short-term continence results are encouraging with less associated operative morbidity.


Subject(s)
Suburethral Slings , Urinary Incontinence, Stress/surgery , Female , Humans , Treatment Outcome , Urologic Surgical Procedures/methods
3.
Can J Urol ; 16(2): 4536-40, 2009 Apr.
Article in English | MEDLINE | ID: mdl-19364425

ABSTRACT

INTRODUCTION AND OBJECTIVE: Hunner's ulcer subtype interstitial cystitis (IC) is characterized by the presence of circumscribed inflammatory ulcerations in the bladder wall identified during endoscopic examination of individuals with irritative voiding symptoms and pelvic pain. We present our experience with management of this subgroup with intralesional submucosal injection of corticosteroid. METHODS: Prospective analysis of patients presenting with Hunner's ulcer subtype IC was performed between November 2006 to April 2008. All patients underwent flexible cystoscopy and biopsy confirming the presence of Hunner's ulcer(s). Under general anesthesia, 10 ml of triamcinolone acetonide (40 mg/ml) was injected in 0.5 ml aliquots into the submucosal space of the center and periphery of ulcer(s) using an endoscopic needle. Patient symptoms and quality of life was assessed using two validated questionnaires, the International Prostate Symptom Score (IPSS) and the Pelvic Pain and Urgency/Frequency (PUF) symptom scale. Each questionnaire was administered prior to therapy and 4 weeks postoperatively. The postoperative interview included the Patient Global Impression of Change (PGIC). RESULTS: Thirty patients with Hunner's ulcer subtype IC underwent endoscopic submucosal injection of triamcinolone. The mean preoperative and postoperative IPSS were 21.1 and 11.3, respectively. The mean preoperative and postoperative PUF scores were 20.0 and 11.0, respectively. PGIC assessment revealed 21 of 30 patients (70%) very much improved. No perioperative complications were noted. CONCLUSION: In Hunner's ulcer IC, submucosal injection of triamcinolone is well tolerated. This treatment offers significant improvement in symptoms and quality of life based on responses from validated questionnaires administered before and after therapy.


Subject(s)
Cystitis, Interstitial/drug therapy , Glucocorticoids/administration & dosage , Triamcinolone Acetonide/administration & dosage , Cystitis, Interstitial/pathology , Cystoscopy , Humans , Injections, Intralesional , Prospective Studies , Quality of Life , Treatment Outcome
4.
J Urol ; 181(6): 2599-607, 2009 Jun.
Article in English | MEDLINE | ID: mdl-19375110

ABSTRACT

PURPOSE: We assessed the effect of tolterodine extended release plus behavioral intervention on treatment satisfaction and bladder diary variables in patients with overactive bladder who had been previously treated and were dissatisfied with tolterodine or other antimuscarinics. MATERIALS AND METHODS: This 16-week, multicenter, open label study included eligible patients 18 years old or older who reported overactive bladder symptoms 3 months or greater in duration, 8 or greater micturitions and 2 or greater urgency related micturitions per 24 hours, and 1 or greater urgency urinary incontinence episodes in a 5-day bladder diary at baseline as well as dissatisfaction with prior antimuscarinic medication. Patients received tolterodine extended release plus self-administered behavioral intervention, consisting of an educational pamphlet with verbal reinforcement, for 8 weeks. Satisfied patients continued with this therapy and dissatisfied patients received tolterodine extended release plus individualized behavioral intervention, consisting of in-depth interaction with a clinician to refine behavioral techniques, for 8 weeks thereafter. Patients rated treatment satisfaction at weeks 8 and 16, and completed a 5-day bladder diary at weeks 4, 8, 12 and 16, respectively. RESULTS: At weeks 8 and 16, 346 and 357 patients or 91% of the total cohort reported being at least a little satisfied with tolterodine extended release plus behavioral intervention, including 201 (53%) and 252 (64%), respectively, who were very satisfied. Of the 33 patients who were dissatisfied at week 8, 25 (76%) reported treatment satisfaction at week 16 after individualized behavioral intervention. Compared with baseline all bladder diary variables were significantly improved by week 4 (p <0.0001). Patients who were dissatisfied with prior tolterodine or other antimuscarinic treatment reported similar results. CONCLUSIONS: Tolterodine extended release plus behavioral intervention resulted in high treatment satisfaction and improved bladder diary variables in patients who had previously been treated and were dissatisfied with tolterodine or other antimuscarinics.


Subject(s)
Behavior Therapy , Benzhydryl Compounds/therapeutic use , Cresols/therapeutic use , Muscarinic Antagonists/therapeutic use , Patient Satisfaction , Phenylpropanolamine/therapeutic use , Urinary Bladder, Overactive/therapy , Adult , Aged , Aged, 80 and over , Combined Modality Therapy , Female , Humans , Male , Middle Aged , Tolterodine Tartrate , Young Adult
5.
Can J Urol ; 15 Suppl 1: 44-52; discussion 52-3, 2008 Aug.
Article in English | MEDLINE | ID: mdl-18700065

ABSTRACT

Interstitial cystitis also known as painful bladder disorder refers to individuals with chronic bladder inflammation of unknown cause. The presentation of disabling symptoms of urgency, frequency, nocturia, and varying degrees of suprapubic discomfort, is one that the primary care physician will encounter frequently as the prevalence of interstitial cystitis ranges from 10.6 cases per 100,000 to as high as one in 4.5 women, depending upon the criteria used for its diagnosis. Many etiologies are possible. The disorder can be divided clinically into two groups-ulcerative and non-ulcerative-based on cystoscopic findings and response to treatment. In general the diagnosis is made by excluding known treatable causes of bladder irritation. Criteria for the disease are lacking. Management follows an approach of applying the least invasive therapy that affords sufficient relief of symptoms. This monograph attempts to guide the practicing primary care physician from the clinical presentation to a sensible diagnostic work-up and reviews the present management strategies in patients with interstitial cystitis.


Subject(s)
Cystitis, Interstitial , Family Practice/methods , Physicians, Family , Anti-Inflammatory Agents/therapeutic use , Clinical Competence , Cystectomy/methods , Cystitis, Interstitial/diagnosis , Cystitis, Interstitial/physiopathology , Cystitis, Interstitial/therapy , Diagnosis, Differential , Family Practice/standards , Humans , Prognosis , Urodynamics/physiology
6.
Can J Urol ; 15(4): 4153-7, 2008 Aug.
Article in English | MEDLINE | ID: mdl-18706141

ABSTRACT

OBJECTIVE: The transobturator sling (TOS) is safe and effective for the treatment of female stress urinary incontinence (SUI). Controversy exists regarding its efficacy in patients with low valsalva leak point pressure (VLPP), a marker of intrinsic sphincter deficiency (ISD). We review our experience of TOS in the treatment of women with SUI and low VLPP. METHODS: Patients diagnosed with stress or mixed incontinence treated with TOS were identified by retrospective review. All procedures were performed with local anesthesia and intravenous sedation. Stress incontinence and VLPP were determined preoperatively with urodynamic testing. Chart review identified demographics, perioperative variables, complications, and subjective cure. Low VLPP was defined as VLPP less than 60 cm H2O. RESULTS: From November 2003 to February 2006, 151 consecutive women underwent TOS. Twenty-seven patients were excluded who exhibited incontinence with cough but not valsalva on preoperative urodynamic testing. Of the remaining 124 patients, 29% had low VLPP and 71% had higher VLPP. There was no difference in subjective cure between patients with low (94%) and higher VLPP (84%) overall (p = 0.12) or in patients with 12 months or more of follow-up (93% versus 79%, p = 0.40). Patients with low VLPP were more likely to be older (p = 0.036), and have pure SUI (p = 0.019). CONCLUSIONS: TOS is effective for patients with low VLPP. Women with SUI and ISD without a fixed urethra should be considered candidates for TOS. The use of intravenous sedation during sling placement allows the surgeon to perform an intraoperative cough test, permitting tensioning of the TOS in relation to the patient's ISD.


Subject(s)
Cough/physiopathology , Monitoring, Intraoperative/methods , Prosthesis Implantation/instrumentation , Suburethral Slings , Urinary Incontinence, Stress/surgery , Valsalva Maneuver/physiology , Female , Follow-Up Studies , Humans , Middle Aged , Retrospective Studies , Treatment Outcome , Urinary Incontinence, Stress/diagnosis , Urinary Incontinence, Stress/physiopathology , Urodynamics
7.
Expert Rev Med Devices ; 5(4): 507-23, 2008 Jul.
Article in English | MEDLINE | ID: mdl-18573049

ABSTRACT

Stress urinary incontinence is one of the most prevalent and costly problems encountered by the international medical community. The exact mechanism of stress incontinence remains elusive. Early management relied on behavioral modification but, as more advanced anatomic and urodynamic research surfaced, the focus shifted to surgical correction. Initial innovations provided a compressive force/hammock to support the urethra and bladder neck. For almost a century, the pubovaginal sling provided this support, with 70-90% cure rates at the expense of significant voiding dysfunction. Later work has highlighted the interaction of muscles and ligaments as a midurethral kinking mechanism to prevent leakage. With this knowledge came the advent of tension-free vaginal taping. Further modifications led to the development of other midurethral slings, producing similar cure rates while minimizing complications.


Subject(s)
Suburethral Slings , Urinary Incontinence, Stress/surgery , Urologic Surgical Procedures/instrumentation , Female , Humans , Prosthesis Design , Treatment Outcome , Urinary Incontinence, Stress/etiology , Urologic Surgical Procedures/adverse effects
8.
Dig Dis Sci ; 53(5): 1246-51, 2008 May.
Article in English | MEDLINE | ID: mdl-17932763

ABSTRACT

PURPOSE: Interstitial cystitis (IC) often coexists with irritable bowel syndrome (IBS). IBS may be explained by small-intestinal bacterial overgrowth (SIBO), which increases immune activation and visceral hypersensitivity. This prospective pilot study tested hypotheses that IC patients with gastrointestinal (GI) symptoms have SIBO, that nonabsorbable antibiotic use improves symptoms, and that improvement is sustained by prokinetic therapy. METHODS: Consecutive IC patients with GI symptoms had lactulose breath testing (LBT). Those with abnormal results received rifaximin 1,200-1,800 mg/day for 10 days then tegaserod 3 mg/nightly. Questionnaires addressed IC and GI global improvement. RESULTS: Of 21 patients, 17 (81%) had abnormal LBTs. Of 15 patients treated, GI global improvement was moderate to great in 11 (73%) and sustained in ten (67%). IC global improvement was moderate to great in six (40%) and sustained in seven (47%). CONCLUSIONS: A majority of IC patients and GI symptoms had an abnormal LBT suggesting SIBO. Rifaximin improved symptoms, which was sustained by tegaserod.


Subject(s)
Cystitis, Interstitial/complications , Cystitis, Interstitial/metabolism , Intestine, Small/metabolism , Intestine, Small/microbiology , Irritable Bowel Syndrome/complications , Irritable Bowel Syndrome/metabolism , Adult , Aged , Aged, 80 and over , Anti-Bacterial Agents/pharmacology , Breath Tests , Cystitis, Interstitial/drug therapy , Female , Gastrointestinal Agents/therapeutic use , Humans , Indoles/therapeutic use , Irritable Bowel Syndrome/drug therapy , Irritable Bowel Syndrome/microbiology , Middle Aged , Pilot Projects , Prospective Studies , Rifamycins/therapeutic use , Rifaximin , Serotonin Receptor Agonists/therapeutic use , Statistics, Nonparametric , Surveys and Questionnaires , Treatment Outcome
9.
Neurourol Urodyn ; 27(3): 212-21, 2008.
Article in English | MEDLINE | ID: mdl-17580357

ABSTRACT

AIMS: Evaluate duloxetine in the treatment of women with mixed urinary incontinence (MUI). MATERIALS AND METHODS: 588 women, 19-85 years old with >or=4 incontinence episodes/week were randomly assigned to duloxetine 80 mg/day (N = 300) or placebo (N = 288). Patients were classified into three symptom subgroups: stress or urge predominant MUI (SPMUI or UPMUI) or balanced MUI (BMUI) based on their responses to the validated Stress/Urge Incontinence Questionnaire. Half the population was randomly assigned to have urodynamics; SPMUI, UPMUI, and BMUI condition diagnoses were based on signs, symptoms, and urodynamic observations. The primary outcome measure was the change in incontinence episode frequency (IEF). Secondary outcome measures included the Incontinence Quality of Life (I-QOL) scores, the ICI Quality of Life (ICIQ-SF) score, and the Patient Global Impression of Improvement (PGI-I) rating. RESULTS: At baseline, women with SPMUI averaged 15.9 IEF/week (61% stress), those with UPMUI averaged 13.2 (70% urge), and those with BMUI averaged 16.5 (52% urge). Overall IEF decreases were significantly greater with duloxetine than placebo (median percent reduction 60% vs. 47%, P < 0.001); both UUI and SUI episodes were significantly decreased with duloxetine (median SUI IEF reduction 59% vs. 43%, P = 0.001; UUI IEF reduction 58% vs. 40%, P < 0.001). Duloxetine IEF decreases were significantly greater for patients with SPMUI conditions and symptoms and for those with UPMUI conditions but not symptoms. Significant benefits were also demonstrated with duloxetine for improvements in I-QOL total score (11.5 points vs. 8.1 points, P = 0.002), all three I-QOL subscale scores, and for the ICIQ-SF score (-2.6 vs. -1.7, P = 0.002) as well as for PGI-I ratings (much/very much better 44.2% vs. 27.3%, P = 0.001). CONCLUSION: Duloxetine demonstrated significant efficacy in this population of women with MUI.


Subject(s)
Neurotransmitter Uptake Inhibitors/therapeutic use , Thiophenes/therapeutic use , Urinary Incontinence, Stress/drug therapy , Urinary Incontinence, Urge/drug therapy , Adult , Aged , Aged, 80 and over , Canada , Double-Blind Method , Duloxetine Hydrochloride , Female , Humans , Middle Aged , Neurotransmitter Uptake Inhibitors/adverse effects , Patient Satisfaction , Quality of Life , Severity of Illness Index , Surveys and Questionnaires , Thiophenes/adverse effects , Treatment Outcome , United Kingdom , United States , Urinary Incontinence, Stress/physiopathology , Urinary Incontinence, Urge/physiopathology , Urodynamics
10.
Mo Med ; 104(5): 430-4, 2007.
Article in English | MEDLINE | ID: mdl-18018531

ABSTRACT

This article gives the practicing physician a summary of normal female pelvic and vaginal support structures and the etiology of pelvic prolapse. The most recent grading system for pelvic prolapse is reviewed. Changes on the various organ systems in the pelvis follow and concentrate on urinary incontinence, dyspareunia and bowel dysfunction. A review of the various non-surgical and surgical corrective procedures and a summary of the literature conclude the presentation.


Subject(s)
Uterine Prolapse/etiology , Uterine Prolapse/therapy , Female , Humans , Uterine Prolapse/diagnosis
13.
Expert Rev Med Devices ; 2(5): 613-22, 2005 Sep.
Article in English | MEDLINE | ID: mdl-16293073

ABSTRACT

Minimally invasive suburethral sling procedures have become a mainstay for the surgical treatment of stress urinary incontinence in women. The transvaginal tape sling is the urethral sling most commonly used today. Although the transvaginal tape procedure is safe and efficacious, complications such as bladder, bowel and blood vessel injury have been reported. The most promising recent innovation in minimally invasive surgery for stress urinary incontinence is the transobturator approach for sling placement. This review will cover the mechanism of continence, rationale for the use of suburethral slings in the treatment of stress urinary incontinence, characteristics of polypropylene, comparison of the slings that are commercially available and early data on the efficacy of the transobturator approach in the treatment of stress urinary incontinence.


Subject(s)
Biocompatible Materials , Prostheses and Implants , Surgical Flaps , Surgical Mesh , Urinary Incontinence, Stress/surgery , Urologic Surgical Procedures/instrumentation , Urologic Surgical Procedures/methods , Minimally Invasive Surgical Procedures/instrumentation , Minimally Invasive Surgical Procedures/methods , Practice Guidelines as Topic , Practice Patterns, Physicians' , Treatment Outcome , Urethra/surgery
14.
Obstet Gynecol ; 106(4): 767-73, 2005 Oct.
Article in English | MEDLINE | ID: mdl-16199634

ABSTRACT

OBJECTIVE: To evaluate the reproducibility, construct validity, and preferences for the 2-item Stress/Urge Incontinence Questionnaire. METHODS: The questionnaire asks a patient to recall the number of stress urinary incontinence and urge urinary incontinence episodes she experienced during the preceding week. The 4-week prospective study included 3 office visits and enrolled women with stress, urge, or mixed urinary incontinence symptoms. The test-retest reproducibility was assessed after 3 days, and the construct validity of the questionnaire was evaluated against a diary and other measures of incontinence severity and effect. The bother associated with completing (patients) or analyzing (physicians) the diary was assessed. Both groups also reported their time requirements and preferences for the questionnaire or diary. RESULTS: Reproducibility for the classification of symptoms was moderately strong (kappa = .536). Test-retest agreement was good (64-80%) for all but balanced mixed incontinence (38%). Intraclass correlations revealed good reproducibility for the number of stress (.694), urge (.703), and total (.726) incontinence episodes. Significant (P < .01) correlations with other measures of incontinence established construct validity. Patients and physicians reported it took less time to complete the questionnaire than the diary, but the majority said the completion or analysis of the diary was of little or no bother and preferred the diary. CONCLUSION: The Stress/Urge Incontinence Questionnaire is a valid tool that can be used in clinical practice to differentiate between symptoms of stress and urge urinary incontinence to make an initial diagnosis, especially in primary care where incontinence is not a focus of the practice.


Subject(s)
Surveys and Questionnaires , Triage , Urinary Incontinence, Stress/diagnosis , Adult , Aged , Aged, 80 and over , Attitude of Health Personnel , Female , Humans , Middle Aged , Patient Satisfaction , Physicians/psychology , Reproducibility of Results , Severity of Illness Index
15.
Curr Urol Rep ; 6(5): 385-92, 2005 Sep.
Article in English | MEDLINE | ID: mdl-16120242

ABSTRACT

Midurethral slings have proven to be efficacious in the surgical treatment of stress urinary incontinence (SUI) in women. A relatively new approach to the midurethral sling technique is the transobturator route for placement of the sling. This approach offers the theoretical safety advantage of avoiding the retroperitoneal space. The procedure has been pioneered in Europe and is now being practiced in the United States. In this article, we describe the theory behind urethral slings for SUI, the anatomy of the obturator canal, and early data on the safety and efficacy of transobturator urethral slings in the treatment of SUI.


Subject(s)
Prosthesis Implantation/instrumentation , Surgical Mesh , Urethra/surgery , Urinary Incontinence, Stress/surgery , Urologic Surgical Procedures/methods , Female , Humans
16.
Urology ; 65(1): 55-9, 2005 Jan.
Article in English | MEDLINE | ID: mdl-15667863

ABSTRACT

OBJECTIVES: To assess prospectively the degree of urethral mobility in the preoperative and postoperative periods after the transobturator tape procedure and correlate the findings with surgical outcome. METHODS: Thirty-six consecutive patients with stress urinary incontinence underwent the transobturator tape procedure. A cotton-swab test was performed before the procedure and at the 6-week postoperative follow-up visit to evaluate proximal urethral mobility. Cure was defined as the absence of leak during cough stress testing at cystometric capacity. RESULTS: Of the 36 patients, 26 were available for the complete follow-up evaluation. The mean preoperative and postoperative resting cotton-swab test values were 11.7 degrees and 13.6 degrees, respectively (P = 0.347). The mean preoperative and postoperative straining cotton-swab test values were 57.3 degrees and 48.4 degrees, respectively (P = 0.047). Of the 36 patients, 21 had a straining cotton-swab test result of 30 degrees or greater after surgery, and 19 (90.4%) of these 21 patients were objectively cured by the procedure. Overall, 21 patients (84%) were objectively cured of stress urinary incontinence. Four patients had urinary leakage during stress testing at cystometric capacity. Three of these patients reported subjective cure and one noted improvement. Of the 5 patients with a negative cotton-swab test after surgery, 2 were cured (50%), 2 were not cured, and 1 did not undergo cough stress testing at cystometric capacity because of urgency at 200-mL limiting bladder filling. CONCLUSIONS: The cure of urodynamic stress incontinence using the transobturator tape procedure does not require the correction of proximal urethral mobility.


Subject(s)
Prostheses and Implants , Urethra/physiopathology , Urinary Incontinence, Stress/surgery , Urologic Surgical Procedures/instrumentation , Adult , Aged , Cough , Female , Follow-Up Studies , Humans , Middle Aged , Motion , Postoperative Period , Treatment Outcome , Urodynamics
17.
J Endourol ; 18(7): 620-3; discussion 623-4, 2004 Sep.
Article in English | MEDLINE | ID: mdl-15597647

ABSTRACT

BACKGROUND AND PURPOSE: Laparoscopic sacrocolpopexy offers a minimally invasive approach to correcting vaginal vault prolapse. We describe our operative technique and review our experience. PATIENTS AND METHODS: A retrospective study of 10 patients who underwent laparoscopic sacrocolpopexy between February 2000 and June 2002 for posthysterectomy vaginal vault prolapse was performed. Data collected included operative time, complications, hospital stay, and postoperative morbidity. RESULTS: One patient underwent primary laparoscopic repair of an intraoperative bladder injury. Conversion from a laparoscopic to an open procedure was required in one patient because of dense bowel adhesions in the pelvis. The mean analgesic (morphine sulfate equivalent) requirement was 7.3 mg (range 5-21 mg). With a mean follow-up of 16 months (range 5-32 months), prolapse recurred in one patient. CONCLUSION: In the short term, laparoscopic sacrocolpopexy appears to be an effective approach for the treatment of vaginal vault prolapse with minimal postoperative pain and morbidity.


Subject(s)
Colposcopy/methods , Laparoscopy , Uterine Prolapse/surgery , Adult , Aged , Aged, 80 and over , Colposcopy/adverse effects , Female , Humans , Intraoperative Complications , Middle Aged , Recurrence , Reoperation , Retrospective Studies , Treatment Outcome , Urinary Bladder/injuries , Wounds and Injuries/surgery
18.
Urology ; 64(5): 1030, 2004 Nov.
Article in English | MEDLINE | ID: mdl-15533504

ABSTRACT

Voiding dysfunction after mid-urethral sling procedures is uncommon but not completely avoidable. We report on a method to adjust the transobturator mid-urethral sling under local anesthesia in the early postoperative period for postoperative voiding difficulty. At postoperative day 17 and 18, 2 women, who had undergone the transobturator tape procedure for stress incontinence, underwent successful loosening of the mesh through the previous vaginal incision, without the need to transect or remove the tape. Both patients had immediate resolution of their symptoms while maintaining urinary continence.


Subject(s)
Postoperative Complications/therapy , Urination Disorders/therapy , Urologic Surgical Procedures , Adult , Female , Humans , Urethra/surgery , Urinary Incontinence, Stress/surgery
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