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Investigation of cytokine polymorphisms on viral infections after renal transplantation exhibit association between IFN-γ +874 A > T and CMV manifestations.
de Almeida, Stéphanie Gomes Santos; Knakcfuss, Fabiana Batalha; Assis, Lívia Maria; de Sousa, Regina Celia Gonçalves; Matuck, Tereza Azevedo; de Carvalho, Deise de Boni Monteiro; Machado, Ricardo Luiz Dantas; Guimarães, Maria Angelica Arpon Marandino; Varella, Rafael Brandão.
Int J Immunogenet ; 49(6): 379-383, 2022 Dec.
Article in English | MEDLINE | ID: mdl-36193010

ABSTRACT

We investigated the effects of TNF-α, IFN-γ, IL-10 polymorphisms on viral infections (CMV, BKPyV, HHV-6, EBV) after renal transplantation. IFN-γ+874 A > T (lower IFN production) was associated with CMV disease (p = .039) in patients under mycophenolate-based therapy and graft failure (p = .025). This study underscores the role of IFN-γ+874 SNP in CMV infection.


Subject(s)
Cytomegalovirus Infections , Kidney Transplantation , Humans , Cytomegalovirus/genetics , Kidney Transplantation/adverse effects , Cytokines , Cytomegalovirus Infections/genetics , Interferon-gamma/genetics
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