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Bioorg Med Chem Lett
; 18(23): 6222-6, 2008 Dec 01.
Article
in English
| MEDLINE
| ID: mdl-18926700
ABSTRACT
High-throughput screening of the GSK compound collection against the P2Y(1) receptor identified a novel series of tetrahydro-4-quinolinamine antagonists. Optimal substitution around the piperidine group was pivotal for ensuring activity. An exemplar analog from this series was shown to inhibit platelet aggregation.