Natural product-like and other biologically active heterocyclic libraries using solid-phase techniques in the post-genomic era.

High-throughput technologies allow the selection of new biological targets for drug discovery in the post-genomic era. These tools increase the need of new methods to rapidly obtain potent small molecules and natural products to discover new lead structures. In particular, the solid-phase synthesis offers a great potential to obtain large compound sets.

Extending due process protections in managed care credentialling to hospital privileges.

The Article analyzes two recent state court decisions granting due process rights to physicians deselected from managed care networks. The author applauds these decisions and argues that managed care organizations wishing to deselect a physician should be required to demonstrate (1) that they have a legitimate reason for doing so relating to quality of care, economic factors, or administrative considerations, and (2) that the deselection will not unduly affect the quality of healthcare available in the network. In addition, the author contends that these same due process requirements may be applied to the closely analogous area of hospital staff privileges in situations in which the privileges of hospital-based practitioners are tied to employment, or the grant or termination of exclusive contracts.

Involuntary transfers and discharges of nursing home residents under federal and state law.

When, as projected, nearly one out of every four Americans is age sixty-five or more, one out of every four Americans over sixty-five will spend time in a nursing home, and caregiver families scarcely exist, we will no longer be able to avert our eyes from the grim options faced by our senior citizens. Nor will we be able to continue to operate under the comforting but often false illusion that our convenient dispositions are actually serving the best interests of the elderly.

[Pregnancies without complications of patients with jejuno-ileal bypass because of extreme obesity (author's transl)]. / Komplikationslos verlaufende Schwangerschaften bei bestehendem jejunoilealem Bypass wegen extremer Fettsucht.

Report about 3 pregnancies without complications of patients, who had been treated by jejuno-ileal bypass because of extreme obesity. There is no increased risk for the successful finishing of a pregnancy of these patients. A close cooperation between the treating doctors is necessary to cope with possible problems.

[Stenosis of the celiac artery as cause of chronic recurrent pancreatitis (author's transl)]. / Stenose des Truncus coeliacus als Ursache einer chronisch rezidivierenden Pankreatitis.

Report on three clinical examples of the interrelation between chronic recurrent pancreatitits and external compression which cause a stenosis of the celiac artery. If clarification of the etiology of recurrent pancreatitis with the usual examinations is impossible, angiography is very important. A causal therapy is only possible by means of surgical treatment of the stenosis.