[The role of leukocytic infiltration in the development of neurogenic processes in the denervated rat cornea]. / Rol' leikotsitarnoi infil'tratsii v razvitii neirogennykh protsessov v denervirovannoi rogovitse krys.

In early and late stages after different types of deafferentation of rat cornea extents of leukocyte infiltration and pathological changes are variable. Change of thickness of anterior epithelium and substantia propria, stratification of substantia propria fibres as well as epitheliocyte death and erosion occur only at late time intervals of deafferentation (after 1 d) when a large number of leukocytes appear in cornea. One day after the deafferentation performed following preliminary leukopoiesis suppression by irradiation, single leukocytes are encountered only in substantia propria of cornea while anterior epithelium thickness does not differ from that of intact animals, and the extent of pathological changes in substantia propria is reduced. These data demonstrate polymorphonuclear leukocyte participation in the development of neurogenic dystrophia in cornea.

[The effect of electrostimulation of the hypothalamic mamillary nuclei on the vascular permeability of the skin in intact and capsaicin-pretreated rats]. / Vliianie élektrostimuliatsii mamilliarnykh iader gipotalamusa na pronitsaemost' sosudov kozhi u intaktnykh i predvaritel'no obrabotannykh kapsaitsinom krys.

Electrical stimulation of the hypothalamic mamillary nuclei increased the permeability of the skin blood vessels in rats. Pretreatment of the animals with capsaicin prevented the effect. The mamillary nuclei seem to take part in the central mechanisms of efferent function of the capsaicin-sensitive neurons.

[The microcirculatory disorders in deafferentation of the eye]. / Mikrotsirkuliatornye narusheniia pri deafferentatsii glaza.

Microcirculatory disorders occurring in the eye of rats in the early period after deafferentation were studied. The blood flow in the iridic vessels became slower and permeability of the eye vessels was disturbed in the first hours and minutes after retrobulbar injection of the anesthetic trimecaine. Similar changes were encountered in division of the trigeminal nerve branches and in electrocoagulation of the sensory nucleus of the trigeminal nerve as well as in venous congestion induced by applying a ligature to the veins of the eyeball. All these procedures led to corneal edema and development of an inflammatory process. Eye sympathectomy caused neither disorders of vascular permeability nor keratitis. Changes of vascular permeability and tissue edema occurring in the early periods after deafferentation are probably among the causes of the subsequent dystrophic disorders in the peripheral tissue.

[Mechanism of the development of neuroparalytic keratitis]. / Mekhanizm vozniknoveniia neiroparaliticheskogo keratita.

There is a hypothesis that for appearance of the neuroparalytic keratitis a decisive role has cessation of discharge of trophic factors, demonstrating a polypeptide nature. from sensitive nervous endings. In order to check the hypothesis, deafferentation of the eye has been performed by means of electrocoagulation of the trigeminal sensitive nucleus in the medulla oblongata. Despite the fact that as a result of the operation connection of the sensitive cells with the periphery is preserved, the neuroparalytic keratitis occurs at the same time, as after sectioning the trigeminal nerve branching. The suggestion on excessive discharge of catecholamines from the sympathetic terminals as the cause of deafferentational disorders is not confirmed. The eye desympathization does not prevent appearance of the neuroparalytic keratitis. It is supposed that discontinue of information current to the center makes regulation of the peripheral tissues homeostasis impossible, that is the cause of the trophic disturbance.

[Development of neuroparalytic keratitis after retrobulbar administration of trimecaine]. / Razvitie neiroparaliticheskogo keratita posle retrobul'barnogo vvedeniia trimekaina.

The blood flow in the iris vessels slowed down and the vessel permeability increased early after a retrobulbar injection of trimecaine, a local anesthetic, this resulting in the development of tissue edema. Two days later neuroparalytic keratitis developed. The authors suppose that early vascular disorders resultant from blocking of the sensitive nerves are among the causes responsible for later changes in the corneal trophics.

[Effect of deafferentation of the liver on hepatocytes located in various parts of the hepatic lobule]. / Vliianie deafferentatsii pecheni na gepatotsity, raspolozhennye v raznykh chastiakh pechenochnoi dol'ki.

Taking into account the data on functional heterogeneity of hepatocytes, situating in various parts of the hepatic lobule, influence of deafferentation of the cat liver on changes in the size of hepatocytes and their nuclei, as well as contents of glycogen and nucleic acids in their cytoplasm have been investigated. The greatest decrease of the glycogen contents and the greatest increase of the nucleic acids and the nuclei volume take place in hepatocytes, situating around the central vein.