ABSTRACT
New biomarkers of effect of some controlled ambient air pollutants (formaldehyde, carbon monoxide and TSP) were found in two surveys of Moscow residents (apparently healthy and outpatients with allergic diseases) with a help of screening system of biochemical and immunological parameters. Possible mechanisms of the effects, including interference of atmospheric carbon monoxide and sulfur dioxide with corresponding endogenous second messengers, are discussed.
Subject(s)
Biomarkers/analysis , Environmental Illness/epidemiology , Immunity , Particulate Matter/adverse effects , Population Surveillance/methods , Public Health , Urban Population , Adult , Environmental Health , Environmental Illness/diagnosis , Environmental Illness/metabolism , Female , Humans , Incidence , Male , Middle Aged , Moscow/epidemiology , Retrospective Studies , Young AdultABSTRACT
Factor analysis of cross-sensitization to 24 common allergens and correlation analysis of the relationship between the hypersensitivity to the allergens and some biochemical markers (the intensity of serum chemiluminescence, the content of SH-groups, and the activity of lysosomal enzymes) of the health status were carried out in a sample of Moscow residents with allergic diseases. A significant correlation was found between the serum levels of specific IgE antibodies to pollen allergens and the activity of serum acid DNAase (R = 0.498; p = 0.009; N = 67). The revealed regularity may be used to devise a test for the differential diagnosis of pollenoses and suggests that there are possible differences in the levels of apoptosis and cytogenetic damages between patients with pollenoses and those with other allergic diseases.
Subject(s)
Allergens/immunology , Deoxyribonucleases/blood , Hypersensitivity/enzymology , Immunoglobulin E/blood , Pollen/immunology , Adolescent , Adult , Aged , Female , Humans , Hypersensitivity/blood , Male , Middle Aged , Moscow , Regression Analysis , Young AdultABSTRACT
A novel methodological design comprising multilevel assessments of exposures of examinees to controlled ambient air pollution according to the data of route stations was developed to examine the population of large towns. The design was tested in 4 surveys of Moscow residents (apparently healthy and outpatients with a number of chronic diseases). The findings indicate the fundamental possibility of altering the traditional differential design of biomedical surveys of the population, by introducing more evidence-based regression analyses and dividing the contributions of individual chemicals to the observed changes in health indices.
