ABSTRACT
The design and synthesis of three novel polycyclic scaffolds containing sulfoximines are presented in this work, which exemplify that sulfoximines represent a real opportunity for the discovery of new drug candidates. Additionally, the structures present at least two points of diversification and contain a high level of sp3-character, hence being very interesting 3D scaffolds. The compounds synthesized were added to the compound collection of the European Lead Factory.
Subject(s)
Polycyclic Compounds/chemical synthesis , Small Molecule Libraries/chemical synthesis , Sulfoxides/chemical synthesis , Bridged Bicyclo Compounds, Heterocyclic/chemical synthesis , Cycloaddition Reaction , Drug Discovery , Molecular Structure , Pyrazoles/chemical synthesis , Pyrazoles/chemistry , Spiro Compounds/chemical synthesis , StereoisomerismABSTRACT
We report the synthesis, characterization, and electrochemical properties of ten new fullerene derivatives for usage in organic solar cells. The phenyl ring of PCBM was substituted with electron-donating and electron-withdrawing substituents to study their influence on the LUMO level of the parent fullerene. We varied the LUMO level over a range of 86 mV and show a small but significant change of the open circuit voltage upon application in MDMO-PPV:methanofullerene bulk-heterojunction photovoltaic cells. [structure: see text].