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Transmembrane ion conductance by an acyclic bolaamphiphile.
Fyles, T M; Knoy, R.
Org Lett ; 3(9): 1335-7, 2001 May 03.
Article in English | MEDLINE | ID: mdl-11348228

ABSTRACT

[reaction in text] An acyclic bolaamphiphile forms ion channels in vesicles and planar bilayer membranes that are closely similar to the channels formed by related bismacrocyclic compounds. Thus the function of these ion channels does not depend on synthetically difficult macrocyclic subunits.


Subject(s)
Ion Channels/chemistry , Lipid Bilayers/chemistry , Membranes/chemistry , Biological Transport , Ion Channels/metabolism , Magnetic Resonance Spectroscopy , Membranes/metabolism , Models, Molecular , Molecular Structure , Phosphatidylcholines/chemistry , Structure-Activity Relationship , Surface-Active Agents/chemistry
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