Views on aging among undergraduates, faculty, and staff: Domain-specific measurement invariance and comparisons.

Views on aging have been shown to reliably predict various psychological and physical health outcomes. To our knowledge, this is the first study exploring domain-specific views on aging using a university sample including students, faculty, and staff (N = 646). Specifically, we assessed how one's age stereotypes (AS), current self-views on aging (CS), and future self-views on aging (FS) vary among students, faculty, and staff by age and by eight everyday functioning domains using an existing domain-specific scale. In general, the older one becomes, the more positive one's views on aging are in various domains with a few exceptions. No single group (e.g., students, faculty, or staff) consistently had more positive views across domains than the other groups. Moreover, faculty and staff tended to share similar views on aging compared to students. The most salient difference between students and faculty/staff was in the finance domain; students had more positive age stereotypes and future self-views than faculty and staff but not for current self-views. The results highlight the importance of examining the domain-specific age stereotypes, current and future self-views on aging to understand the differences among university populations and provide implications for future educational programs on ageism.

Longitudinal purpose in life trajectories: Examining predictors in late midlife.

Research shows midlife adults consistently report higher purpose in life (PIL) than older adults. However, less is known about the changes in PIL during the transition from midlife to older adulthood. This study examined 5-year changes of PIL among late-midlife adults in the Foley Longitudinal Study of Adulthood (n = 163, MAge = 56.37). Results showed that most midlife adults reported higher-stable PIL whereas some of them showed lower-stable PIL, with trait conscientiousness and race being significant predictors of PIL. Future studies should investigate when PIL tends to stabilize and how personality and racial experiences influence the development of PIL. (PsycINFO Database Record

Abnormal neural activity in partially remitted late-onset depression: an fMRI study of one-back working memory task.

Only half of the geriatric patients with major depressive disorder (MDD) can reach full remission after treatment of half a year. This study was designed to examine the neural responses in the partial responders of late-onset MDD. We used 3-Tesla functional magnetic resonance imaging to assess the patterns of cerebral activation/deactivation in the performance of a one-back version of the n-back working memory task. We recruited 14 major depressive patients who reached partial remission after at least half a year of pharmacological intervention, compared with 14 non-depressive controls. There were no significant between-group differences in the demographical profiles and working memory performance, which was true for both accuracy and reaction time. Brain masks encompassing the neural responses of activation/deactivation were constructed from the non-depressive controls. The depressive group shows enhanced activities at left middle frontal and left parietal regions, and reduced deactivation at several temporal regions and left amygdala within the masks. Besides, the depressive group activates extra neural nodes at middle frontal and middle temporal regions outside the masks. The neural responses in the left amygdala are significantly correlated with the severity of depression and comorbid anxiety. The loss of deactivation in the left amygdala and the temporal areas in cognitive endeavor may be related to the refractoriness to treatment.

Study-specific EPI template improves group analysis in functional MRI of young and older adults.

Spatial normalization to a common coordinate space, e.g. via the Montreal Neurological Institute (MNI) brain template, is an essential step of analyzing multi-subject functional MRI (fMRI) datasets. The imperfect compensation for individual regional discrepancies during spatial transformation, which could potentially introduce localization errors of the activation foci and/or reduce the detection sensitivity, may be minimized if a template specifically designed for the subjects of a study is applied. In this fMRI study, we proposed and evaluated the use of a study-specific template (SST) based on the mean of individually normalized echo-planar images for group data analysis. A hand flexion and a word generation tasks were performed on young volunteers in experiment 1. Comparing with the MNI template approach, greater t-values of local maxima and activated voxels were detected within volume-of-interests (VOIs) with the SST approach in both tasks. Moreover, the SST approach reduced Euclidean distances between activation foci of individuals and group by 1.52 mm in motor fMRI and 5.84 mm in language fMRI. Similar results were obtained with or without spatial smoothing of the echo-planar images. Experiment 2 further examined these two approaches in older adults, in which volumetric differences between subjects are of great concerns. With a working memory task, the SST approach showed greater t-values of local maxima and activated voxels within the VOI of prefrontal gyrus. This study demonstrated that the SST resulted in more focused activation patterns and effectively improved the fMRI sensitivity, which suggested potentials of reducing number of subjects required for group analysis.