ABSTRACT
AIM: The aim of this prospective study was to investigate the relationship between periodontitis and preeclampsia in never-smokers. MATERIALS AND METHODS: Pregnant women were recruited at 21 to 24 weeks of gestation from March 2009 to June 2013. Information on demographics, health behaviours, obstetric history, and systemic diseases that can influence periodontal status and preeclampsia was collected. Full-mouth periodontal probing was performed by two trained examiners. The inter-examiner Kappa value was 0.822 for clinical attachment loss (CAL). Periodontitis was defined as clinical periodontal attachment loss (CAL) of 4.0 mm or greater on 2 or more sites not on the same tooth. Information on the occurrence of preeclampsia was collected by five obstetricians. RESULTS: We studied a total of 283 subjects, comprised of 67 subjects with periodontitis and 216 subjects without periodontitis. Of these, 13 (4.6%) women were diagnosed with preeclampsia. After adjusting for all confounders, the adjusted odds ratio of periodontitis for preeclampsia was 5.56 (95% confidence interval of 1.49-20.71). CONCLUSIONS: There was a significant relationship between periodontitis and the occurrence of preeclampsia among never-smokers.
Subject(s)
Periodontitis/complications , Pre-Eclampsia , Adult , Alcohol Drinking , Body Mass Index , Cohort Studies , Dental Devices, Home Care , Dental Scaling , Exercise , Female , Follow-Up Studies , Gestational Age , Health Behavior , Health Status , Humans , Periodontal Attachment Loss/complications , Periodontal Index , Pregnancy , Pregnancy Outcome , Premature Birth , Prospective Studies , Reproductive HistoryABSTRACT
OBJECTIVE: To evaluate the perinatal outcomes and clinical factors of unsuccessful trials of labor (TOLs) in late preterm and term twin pregnancies. METHODS: We enrolled 896 consecutive twin pregnancies delivered between 1999 and 2012 in a single center, which met the following inclusion criteria: a vertex first twin, live twins, and attempted TOLs after 34 weeks. Obstetric characteristics and perinatal outcomes were compared between vaginal delivery and cesarean delivery groups. RESULTS: Successful TOLs were carried out in 81% (726/896). Failed TOLs occurred in 15% (37/247) of late preterm twins and 20% (133/649) of term twins. Comparisons of neonatal outcomes between the groups showed no significant differences in NICU admission, ventilator use, and composite morbidity. On univariable analysis, nulliparity, preeclampsia, induced labor, excessive weight gain, and intertwin weight discordance of >30% showed significant associations with failed TOLs. Multivariable analyses revealed nulliparity (adjusted odds ratio 9.89, 95% confidence interval 4.64-21.1) and preeclampsia (adjusted odds ratio 2.17, 95% confidence interval 1.30-3.63) as significantly associated with failed TOLs. CONCLUSION: In late preterm and term twins, trials of labor can be performed successfully without a significant increase in adverse neonatal outcomes. Nulliparity and preeclampsia are clinical factors associated with failed TOLs in twin pregnancies.
