ABSTRACT
We report a rare case of giant vascular eccrine spiradenoma (GVES) which developed in 56-yr-old Korean woman. It is a rare variant of eccrine spiradenoma (ES), which might be mistaken for angiomatous lesions in view of its florid vascularity and hemorrhagic features. Histogenesis of GVES is not clearly elucidated although it is known that ES presumably originates in the eccrine glands. To clarify the histogenesis of GVES, immunohistochemical stainings using various monoclonal antibodies were also performed. The tumor was composed of three types of cells, namely pale epithelial cells, small basal cells, and myoepithelial cells. Therefore, we conclude that GVES originated from eccrine gland and mainly differentiates toward secretory portion of secretory coil.
Subject(s)
Adenoma, Sweat Gland/pathology , Eccrine Glands/pathology , Sweat Gland Neoplasms/pathology , Actins/analysis , Adenoma, Sweat Gland/blood supply , Adenoma, Sweat Gland/metabolism , Biomarkers/analysis , Eccrine Glands/blood supply , Eccrine Glands/chemistry , Female , Humans , Immunohistochemistry , Keratin-7 , Keratins/analysis , Korea , Membrane Proteins/analysis , Middle Aged , Mucin-1/analysis , Muscle, Smooth/chemistry , Sweat Gland Neoplasms/blood supply , Sweat Gland Neoplasms/metabolismABSTRACT
Becker nevus is an acquired disorder that usually manifests in late childhood or adolescence as a hyperpigmented hypertrichotic patch usually located on the upper trunk or proximal upper extremities. Only a few cases of congenital and familial Becker nevus have been described. Although the lesions may have various shapes, they consistently have a geographic or blocklike configuration in an irregular fashion; a linear pattern has rarely been reported. We describe a case of linear congenial Becker nevus following Blaschko line that appeared at birth on the right shoulder, with hypertrichosis developing 4 years later.
Subject(s)
Hyperpigmentation/pathology , Hypertrichosis/diagnosis , Nevus, Intradermal/congenital , Nevus, Intradermal/pathology , Biopsy, Needle , Child , Follow-Up Studies , Humans , Hyperpigmentation/complications , Hyperpigmentation/diagnosis , Hypertrichosis/complications , Hypertrichosis/pathology , Immunohistochemistry , Male , Nevus, Intradermal/complications , Rare Diseases , Upper ExtremityABSTRACT
Linear psoriasis is an uncommon form of psoriasis characterized by the linear distribution of the psoriatic lesions. It usually follows the lines of Blaschko with unilateral involvement. Poro keratotic eccrine ostial and dermal duct (PEODD) nevus is another rare dermatosis that follows Blaschko's line. The pathogenesis of linear psoriasis and PEODD nevus is unclear, but both could be best explained by a specific somatic mutation. Hence, it has been suggested that the mutation responsible for PEODD nevus would constitute a rare but critical psoriasis gene. In the literature, 1 case of linear psoriasis with PEODD nevus was reported, which may support this suggestion. This article describes another case of linear psoriasis and PEODD nevus. A 7-year-old boy had a 4-month history of multiple psoriasiform plaques, arranged in linear distribution, and had congenital linear hyperkeratotic papules and pits on the right side of his trunk and right arm.
