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J Toxicol Environ Health ; 15(3-4): 503-7, 1985.
Article in English | MEDLINE | ID: mdl-4032496

ABSTRACT

Intratesticular administration of di-n-butyltin (o-hydroxyacetophenone S-methyldithiocarbazate) has been shown to induce marked degenerative changes in the testes of adult rats. The possible mechanism of its action is discussed. In particular, an atrophy of seminiferous tubules with complete arrest of spermatogenesis has been noted.


Subject(s)
Organotin Compounds/toxicity , Testis/drug effects , Animals , Male , Rats , Spermatogenesis/drug effects , Testis/pathology
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