[Diagnosis and therapy of sarcopenia-an update]. / Update zur Diagnose und Therapie der Sarkopenie.

Since 2016 sarcopenia, the age-associated loss of muscle mass, strength and function, has the ICD-10-GM code M62.50 (International Statistical Classification of Diseases and Related Health Problems, 10th Revision, German Modification). The diagnosis of sarcopenia requires the combined presence of low muscle strength and low muscle mass. Well-established approaches for the prevention and therapy of sarcopenia are exercise programs-in particular strength, endurance and power training-and nutritional interventions, preferably a combination of both. Adequate protein intake is considered highly relevant, while the role of other nutrients involved in muscle metabolism (e. g. creatine, vitamin D, antioxidants, omega-3 fatty acids) is less clear, being still the subject of controversial discussions. Innovative pharmacological therapies are currently under investigation and their future relevance for this indication is unclear. In general, it has to be stated that there are still only few intervention studies available that focused specifically on sarcopenia in older individuals. More studies in this rapidly increasing population are urgently needed.

Olive oil attenuates the cholesterol-induced development of nonalcoholic steatohepatitis despite increased insulin resistance in a rodent model.

It is indefinite whether nonalcoholic steatohepatitis (NASH) results as by-product from general metabolic perturbations and adipokine dysregulations or whether defined dietary factors also play a pathogenetic role. Here, we examine the effects of a modification of dietary lipids in a NASH inducing diet on metabolic changes as well as hepatic steatosis, inflammation, and fibrosis in rats. Male Wistar rats were fed with variations of the atherogenic diet (AD), which induces pathophysiological changes resembling human NASH. Dietary variants (AD without cholesterol, cholate, or choline; change of neutral fat to olive oil or coconut oil) were fed for 8 weeks. Insulin resistance, adipokine profile, liver histology, and lipid content as well as expression of proinflammatory and profibrogenic genes were examined. AD led to clear signs of hepatic steatosis and inflammation together with an increase in TNF and collagen type 1 expression. AD without cholesterol showed markedly less liver damage without changes of insulin action and adipokine profile. AD with olive oil and AD without cholate clearly attenuated hepatic inflammation, whereas fat deposition and features of the metabolic syndrome were increased in these animals. Insulin resistance and hepatic fat deposition per se do not cause significant hepatic inflammation in this rodent model. However, dietary cholesterol is an important causal agent for the development of NASH. Olive oil plays a protective role in this respect, which might be due to the high content of monounsaturated fatty acids.

[Correlation of patients age on length of stay and admission rate in a German emergency department]. / Auswirkungen des patientenalters auf aufenthaltszeiten und stationäre aufnahmen in einer deutschen interdisziplinären notaufnahme.

BACKGROUND: This study aimed to examine correlations between patient age, length-of-stay (LOS) in the emergency department (ED), admission rate for various medical disciplines and probabilities of admission in a German interdisciplinary ED. PATIENTS AND METHODS: In a retrospective cohort analysis, 7937 patients of the ED were evaluated for age, gender, ED-LOS and admission rate. Rank correlation coefficients were calculated in order to analyze the influence of patient age for each discipline. Statistical tests were performed to evaluate explorative hypotheses on specific discipline influence of patient age. RESULTS: Patients age significantly differed between the disciplines. There was a strong correlation between patient age and LOS for trauma surgery, visceral surgery and ophthalmology. The correlation between patient age and admission rate was highest in patients with problems regarding internal medicine, trauma surgery and neurology. CONCLUSION: There is a correlation between patients age, LOS and admission rate in the ED.