ABSTRACT
A study of pirprofen (rengasil) combined with small doses of corticosteroids in 93 patients with rheumatoid arthritis during a double blind multicentre testing showed good and satisfactory therapeutic results in 60%. A decrease in morning rigidity, pains in the joints especially at night, the joint index and in the number of inflammed joints was noted. Rengasil tolerance was good, side effects were few. The new nonsteroid antiinflammatory drug rengasil combined with maintenance doses of corticosteroids can be recommended for a prolonged treatment of patients with rheumatoid arthritis.
Subject(s)
Arthritis, Rheumatoid/drug therapy , Phenylpropionates/therapeutic use , Prednisolone/therapeutic use , Adult , Aged , Clinical Trials as Topic , Double-Blind Method , Drug Therapy, Combination , Female , Humans , Male , Middle Aged , Phenylpropionates/administration & dosage , Piroxicam/administration & dosage , Piroxicam/therapeutic use , Prednisolone/administration & dosageABSTRACT
In coronary patients with relatively intact myocardial function, tobanum increases physical stress tolerance and produces positive central hemodynamic shifts, while myocardial contractility is depressed insignificantly. In patients with low myocardial functional reserve, these parameters, on the contrary, deteriorate, particularly during exercise. Combined use of tobanum and corinfar in patients with impaired myocardial contractility controls cardio- and hemodynamic shifts and increases physical stress tolerance.
