ABSTRACT
AIM: This study aimed to identify the postoperative histological features affecting the prognosis of patients with early-stage cervical cancer who underwent open radical hysterectomy. METHODS: This retrospective study enrolled 374 patients with pT1a, 1b1 and 2a1 early-stage cervical cancer who underwent open radical hysterectomy between 2001 and 2018. Survival outcomes were analyzed by Kaplan-Meier method and compared with log-rank test. Using the Cox proportional hazards regression test, we conducted a multivariate analysis for disease-free survival and overall survival. RESULTS: Others histology, including other epithelial tumors and neuroendocrine tumors, had a significantly worse prognosis in both disease-free survival and overall survival than those of squamous cell carcinoma and adenocarcinoma (hazard ratio, 4.37 and 11.76; P = 0.006 and P = 0.002, respectively), along with lymph node metastasis (hazard ratio, 2.99 and 7.03; P = 0.009 and P = 0.001, respectively). CONCLUSION: Others histology including adenosquamous carcinoma had a poor prognosis in early-stage cervical cancer as with high-risk factors.
Subject(s)
Carcinoma, Adenosquamous , Uterine Cervical Neoplasms , Carcinoma, Adenosquamous/pathology , Carcinoma, Adenosquamous/surgery , Female , Humans , Hysterectomy , Neoplasm Staging , Prognosis , Retrospective Studies , Risk Factors , Uterine Cervical Neoplasms/pathology , Uterine Cervical Neoplasms/surgeryABSTRACT
The lung is an important organ for air breathing in tetrapods and originated well before the terrestrialization of vertebrates. Therefore, to better understand lung evolution, we investigated lung development in the extant basal actinopterygian fish Senegal bichir (Polypterus senegalus). First, we histologically confirmed that lung development in this species is very similar to that of tetrapods. We also found that the mesenchymal expression patterns of three genes that are known to play important roles in early lung development in tetrapods (Fgf10, Tbx4, and Tbx5) were quite similar to those of tetrapods. Moreover, we found a Tbx4 core lung mesenchyme-specific enhancer (C-LME) in the genomes of bichir and coelacanth (Latimeria chalumnae) and experimentally confirmed that these were functional in tetrapods. These findings provide the first molecular evidence that the developmental program for lung was already established in the common ancestor of actinopterygians and sarcopterygians.
Subject(s)
Fish Proteins/genetics , Fishes/growth & development , Lung/growth & development , Animals , Biological Evolution , Chick Embryo , Chickens/genetics , Embryo, Nonmammalian , Enhancer Elements, Genetic , Female , Fishes/embryology , Fishes/genetics , Fishes/physiology , Gene Expression Regulation, Developmental , Larva , Lung/physiology , Male , MesodermABSTRACT
Neonatal lupus erythematosus (NLE) is an autoimmune disease associated with maternal anti-SS-A/Ro and anti-SS-B/La antibodies. NLE is characterized by cutaneous erythema, congenital heart block (CHB), hepatic dysfunction and hematological abnormalities. CHB is irreversible, usually requiring a pacemaker, but other symptoms are reversible and most disappear within 6 months in parallel with declining antibody levels. In Japan, 193 cases of NLE were reported between 1971 and 2008. Most showed erythema, and only 23% of cases presented with CHB. Conversely, antibody status had not been examined in many infants presenting with CHB during the same period. Most pregnant woman with anti-SS-A/Ro and anti-SS-B/La antibodies are asymptomatic, and antibody status is first indicated when their child shows symptoms of NLE. These women show a greater risk of delivering an infant with CHB than normal. CHB is important because the main morbidity and mortality of NLE is from CHB. All clinicians should be familiar with the characteristics of NLE. We believe all pregnant women should be screened for anti-SS-A/Ro and anti-SS-B/La antibodies.
Subject(s)
Antibodies, Antinuclear/immunology , Heart Defects, Congenital , Lupus Erythematosus, Systemic/congenital , Pregnancy Complications , Erythema , Female , Humans , Infant, Newborn , Japan , Lupus Erythematosus, Systemic/diagnosis , Lupus Erythematosus, Systemic/physiopathology , Maternal-Fetal Exchange , Neonatal Screening , Pregnancy , Serologic TestsABSTRACT
BACKGROUND: Mechanic's hand is a defined specific skin eruption associated with dermatomyositis; there are few reports concerning its histopathology. As mechanic's hand clinically resembles hand eczema, it is important to distinguish between these two conditions. AIM: To determine the characteristic clinical and histopathologic features of mechanic's hand, and to clarify whether these two conditions can be differentiated by histopathologic findings. METHODS: We analyzed clinicopathologically five patients with mechanic's hands who visited our clinic between 2006 and 2007. RESULTS: The clinical features of mechanic's hands were discrete hyperkeratotic erythema on the ulnar aspect of the thumbs and the radial aspect of the fingers. In all five cases, the histologic findings included marked hyperkeratosis, focal parakeratosis, psoriasiform acanthosis, and colloid bodies in the epidermis. There were mononuclear cell infiltrates around the blood vessels, and mucin deposition was observed in the dermis. CONCLUSIONS: The histopathologic findings of mechanic's hands are specific and different from those of eczema. A histopathologic examination is useful for the diagnosis of mechanic's hands associated with dermatomyositis and a high incidence of interstitial pneumonia.
