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1.
Int Arch Occup Environ Health ; 96(1): 155-166, 2023 01.
Article in English | MEDLINE | ID: mdl-35913561

ABSTRACT

PURPOSE: This study investigated the association between menstrual symptoms and the intention to leave work among female nurses in Japan. METHODS: This cross-sectional study investigated female nurses (n = 317) at two university hospitals. The items measured were their characteristics (e.g., age, body mass index), "intention to leave" work, somatic symptoms related with menstruation, self-reported menstrual characteristics (e.g., pain), physical workloads (e.g., working hours and night shifts) and psychological workloads, measured with the Copenhagen Burnout Inventory (CBI), and the Job Content Questionnaire (JCQ). Participants with at least four somatic symptoms (e.g., cold, fatigue) which are present during their menstrual cycles were considered to have "somatic symptoms associated with menstruation." We also measured serum ovarian and gonadotropin-releasing hormones. RESULTS: Approximately 40% of women answered "intention to leave" work, and 17% had "somatic symptoms associated with menstruation." Multiple logistic regression analysis suggested that nurses reporting "somatic symptoms associated with menstruation" were more likely to have "intention to leave" work: the adjusted odds ratios (AOR, 95% confidence interval [CI]) were 2.15 (1.12-4.11) in the personal-burnout model, 2.23 (1.16-4.31) in the work-related burnout model, 2.91 (1.52-5.56) in the client-related burnout model; 2.96 (1.50-5.82) in the JCQ model. There was no association between serum and gonadotropin hormones and the intention to leave. CONCLUSION: Somatic symptoms with menstruation were associated with intention to leave work among female Japanese nurses. Intervention for somatic symptoms with menstruation might support nurses to continue work.


Subject(s)
Burnout, Professional , Medically Unexplained Symptoms , Nurses , Nursing Staff, Hospital , Humans , Female , Japan/epidemiology , Cross-Sectional Studies , Intention , Menstruation , Hospitals, University , Nursing Staff, Hospital/psychology , Personnel Turnover , Burnout, Professional/epidemiology , Burnout, Professional/psychology , Surveys and Questionnaires , Job Satisfaction
2.
J Nutr Biochem ; 48: 44-50, 2017 10.
Article in English | MEDLINE | ID: mdl-28759786

ABSTRACT

Previous studies have demonstrated that tocotrienol (T3) has antiatherogenic effects. However, the T3 preparations used in those studies contained considerable amounts of tocopherol (Toc), which might affect the biological activity of T3. There is little information on the effect of highly purified T3 on atherosclerosis formation. This study investigated the effect of high-purity T3 on atherosclerotic lesion formation and the underlying mechanisms. Male apolipoprotein E knockout (apoE-KO) mice were fed a cholesterol-containing diet either alone or supplemented with T3 concentrate (Toc-free T3) or with α-Toc for 12 weeks. ApoE-KO mice fed the 0.2% T3-supplemented diet showed reduced atherosclerotic lesion formation in the aortic root. The 0.2% T3 diet induced Slc27a1 and Ldlr gene expression levels in the liver, whereas the α-Toc-supplemented diet did not affect those expression levels. T3 was predominantly deposited in fat tissue in the T3 diet-fed mice, whereas α-Toc was preferentially accumulated in liver in the α-Toc diet-fed mice. Considered together, these data demonstrate that dietary T3 exerts anti-atherosclerotic effect in apoE-KO mice. The characteristic tissue distribution and biological effects of T3, that are substantially different from those of Toc, may contribute to the antiatherogenic properties of T3.


Subject(s)
Diet, High-Fat/adverse effects , Plaque, Atherosclerotic/drug therapy , Tocotrienols/pharmacology , Animals , Apolipoproteins E/genetics , Blood Glucose/metabolism , Body Weight/drug effects , Gene Expression Regulation/drug effects , Lipids/blood , Liver/drug effects , Liver/physiology , Male , Mice, Knockout , Plaque, Atherosclerotic/etiology , Plaque, Atherosclerotic/genetics , Sucrose/adverse effects , Vitamin E/blood , Vitamin E/metabolism
3.
Biosci Biotechnol Biochem ; 76(9): 1805-8, 2012.
Article in English | MEDLINE | ID: mdl-22972347

ABSTRACT

Supplementation to an AIN93G-based diet of tocotrienol (T3) for 13 weeks administered to Fischer 344/slc rats showed a safety profile with no side effects. Dose-dependent T3 levels were detected in many tissues. Under the present experimental conditions, a continuous intake of the T3 concentrate would be safe in the rats as long as the T3 content was less than 0.20% of the dietary intake.


Subject(s)
Dietary Supplements , Tocotrienols/pharmacokinetics , Vitamin E/pharmacokinetics , Animals , Body Weight/drug effects , Diet , Drug Administration Schedule , Male , Rats , Rats, Inbred F344 , Tissue Distribution , Tocotrienols/administration & dosage , Vitamin E/administration & dosage
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