Subject(s)
Amyloidosis/mortality , Kidney Diseases/mortality , Actuarial Analysis , Adult , Age Factors , Amyloidosis/etiology , Disease Susceptibility , Female , Humans , Kidney Diseases/etiology , Male , Prognosis , Sex Factors , Survival Rate , USSR/epidemiologySubject(s)
Amyloidosis/complications , Cardiomyopathies/etiology , Familial Mediterranean Fever/complications , Kidney Diseases/complications , Amyloidosis/diagnosis , Cardiomyopathies/diagnosis , Echocardiography , Electrocardiography , Familial Mediterranean Fever/diagnosis , Female , Heart/diagnostic imaging , Humans , Kidney Diseases/diagnosis , Kidney Failure, Chronic/complications , Kidney Failure, Chronic/diagnosis , Male , Nephrotic Syndrome/complications , Nephrotic Syndrome/diagnosis , Proteinuria/complications , Proteinuria/diagnosis , Radionuclide Imaging , Technetium Tc 99m PyrophosphateSubject(s)
Amyloidosis/drug therapy , Kidney Diseases/drug therapy , Amyloidosis/etiology , Amyloidosis/mortality , Colchicine/therapeutic use , Dimethyl Sulfoxide/therapeutic use , Drug Evaluation , Humans , Kidney Diseases/etiology , Kidney Diseases/mortality , Serum Amyloid A Protein/analysis , Unithiol/therapeutic useSubject(s)
Amyloidosis/drug therapy , Arthritis, Rheumatoid/drug therapy , Colchicine/therapeutic use , Adult , Amyloidosis/etiology , Arthritis, Rheumatoid/complications , Drug Evaluation , Female , Humans , Kidney Diseases/drug therapy , Kidney Diseases/etiology , Male , Middle Aged , Rectal Diseases/drug therapy , Rectal Diseases/etiology , Serum Amyloid A Protein , Spondylitis, Ankylosing/complications , Spondylitis, Ankylosing/drug therapySubject(s)
Amyloidosis , Amyloidosis/diagnosis , Cardiomyopathies/diagnosis , Echocardiography , Electrocardiography , Humans , Male , Middle Aged , Rectal Diseases/diagnosisABSTRACT
The authors provide the clinico-morphologic evidence for amyloid resorption in patients with periodic disease and amyloidosis under the effect of colchicine.
Subject(s)
Amyloidosis/drug therapy , Colchicine/therapeutic use , Familial Mediterranean Fever/drug therapy , Intestinal Mucosa/pathology , Rectum/pathology , Adolescent , Adult , Amyloidosis/complications , Amyloidosis/pathology , Biopsy , Familial Mediterranean Fever/complications , Familial Mediterranean Fever/pathology , Female , Humans , MaleSubject(s)
Amyloidosis/classification , APUD Cells/metabolism , Aged , Amyloid/metabolism , Amyloidosis/complications , Amyloidosis/diagnosis , Amyloidosis/genetics , Amyloidosis/metabolism , Brain Diseases/etiology , Brain Diseases/metabolism , Cardiovascular Diseases/etiology , Cardiovascular Diseases/metabolism , Diagnosis, Differential , Humans , Male , Myocardium/metabolism , Nervous System Diseases/etiology , Nervous System Diseases/metabolism , Prostatic Diseases/etiology , Prostatic Diseases/metabolismSubject(s)
Amyloid/metabolism , Amyloidosis/classification , Serum Amyloid A Protein/metabolism , Amyloid/analysis , Amyloidosis/etiology , Amyloidosis/metabolism , Animals , Humans , Liver/metabolism , Macrophage Activation , Molecular Weight , Serum Amyloid A Protein/analysis , Serum Amyloid P-Component/metabolismABSTRACT
A patient aged 45 suffering from Whipple's disease is described. The disease has been diagnosed on the basis of morphologic examination of a biopsy specimen of the small intestine mesenteric lymph node. The patient had suffered from the disease for 14 years; during the last 6 months he developed symptoms of the malabsorption syndrome with diarrhea and steatorrhea. The lymph nodes contained numerous macrophages with PAS-positive glycoprotein granules in the cytoplasm, small cavities filled with lipids; electron microscopy has revealed bacillus-like bodies in the macrophages and outside the cells. After the disease has been diagnosed, the patient has been administered a course of tetracycline therapy, that resulted in an improvement of his status.
Subject(s)
Lymph Nodes/pathology , Mesentery/pathology , Whipple Disease/pathology , Biopsy , Humans , Male , Microscopy, Electron , Middle Aged , Whipple Disease/diagnosisABSTRACT
Acetylation phenotype distribution (activity of N-acetyltransferase enzyme) was studied in 29 patients with periodical disease (PD), 73 healthy persons (Armenians), and 20 patients (also Armenians) suffering from epithelial coccygeal cysts. The results obtained indicated the prevalence of slow acetylation phenotype (67%) in the entire Armenian population. PD was characterized by slow acetylation type (28 of 29 patients had slow acetylation with a high frequency of very slow inactivators). The other hereditary pathology, also specific for Armenians (epithelial coccygeal cysts), was characterized by another type of acetylation--a rapid one. The role of slow acetylation as a genetic marker of PD was discussed.
Subject(s)
Acetyltransferases/metabolism , Familial Mediterranean Fever/genetics , Acetylation , Armenia , Ethnicity , Familial Mediterranean Fever/metabolism , Genetic Markers , Humans , PhenotypeABSTRACT
The paper is concerned with an analysis of a course of periodic disease (PD) without and with amyloidosis using also a method of the determination of survival rates in 437 patients followed up for 20 yrs. A course of PD without amyloidosis was benign and did not affect the patients' survival. In the development of amyloidosis the prognosis was unfavorable and determined by a degree of generalization of amyloidosis.
Subject(s)
Amyloidosis/complications , Familial Mediterranean Fever/complications , Adolescent , Adult , Age Factors , Child , Familial Mediterranean Fever/mortality , Female , Follow-Up Studies , Humans , Male , Middle Aged , PrognosisABSTRACT
The paper is concerned with the results of a study of the phagocytic activity of mouse peritoneal macrophages during induction of casein amyloidosis and neutrophils of patients with hereditary amyloidosis and amyloidosis caused by colchicine. The authors discuss the role of phagocytosis in amyloidogenesis.