Subject(s)
Digestive System Surgical Procedures , Ileal Diseases/etiology , Intestinal Volvulus/surgery , Intussusception/etiology , Postoperative Complications , Digestive System Surgical Procedures/methods , Humans , Ileal Diseases/diagnosis , Infant , Intussusception/diagnosis , Male , Postoperative Complications/diagnosisABSTRACT
A 66-year-old man was admitted to undergo investigation for body weight loss. He was diagnosed with pancreatic neuroendocrine carcinoma, and a pancreaticoduodenectomy was performed. Three months after surgery, multiple recurrent liver metastases were observed on CT. We administered the cisplatin(CDDP)/irinotecan(CPT-11)regimen, but decided to discontinue the regimen because of adverse events. One month later, administration of everolimus(10mg/day)was initiated. Lesion loss was observed after 8 months, and the patient achieved a complete response(CR)without abnormal accumulation of FDG on PET-CT. Administration of everolimus was discontinued after 13 months because of peripheral neuropathy. Despite drug withdrawal, the patient has remained in remission for more than 3 years. Everolimus is considered an effective treatment for MANEC from NEC.
Subject(s)
Adenocarcinoma , Antineoplastic Agents , Everolimus , Liver Neoplasms , Pancreatic Neoplasms/pathology , Aged , Antineoplastic Agents/therapeutic use , Antineoplastic Combined Chemotherapy Protocols , Cisplatin/administration & dosage , Everolimus/therapeutic use , Humans , Irinotecan/administration & dosage , Liver Neoplasms/drug therapy , Liver Neoplasms/secondary , Male , Positron Emission Tomography Computed TomographyABSTRACT
A 75-year-old woman presented with right upper quadrant abdominal pain and anorexia. She was diagnosed with descending colon cancer with lymph node and liver metastases. She was treated with preoperative chemotherapy consisting of levofolinate/5-fluorouracil/oxaliplatin (mFOLFOX6). After the completion of 7 courses of chemotherapy, the tumor shrunk remarkably. A left-sided colectomy with radical lymphadenectomy and an extensive posterior segment resection of the liver were performed. Postoperatively, pathological analysis revealed no cancerous cells in the primary tumor, lymph node metastases, or liver metastases. She is currently receiving mFOLFOX6 therapy as adjuvant chemotherapy. In a patient with advanced colon cancer, a complete response of not only the primary tumor but also the lymph node and liver metastases to preoperative chemotherapy is rare. This case demonstrates that mFOLFOX6 therapy is safe and effective as preoperative chemotherapy for advanced colon cancer.
